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The KEAP1/NRF2 Signaling Pathway in Keratinization
Antioxidants, 2020 Keratinization is a tissue adaptation, but aberrant keratinization is associated with skin disorders such as ichthyoses, atopic dermatitis, psoriasis, and acne. The disease phenotype stems from the interaction between genes and the environment; therefore, an understanding of the adaptation machinery may lead to a new appreciation of pathomechanisms ...
Dennis R Roop +2 more
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Understanding the Role of NRF2 Signalling in Cancer
Current Protein & Peptide Science, 2022Abstract: Nuclear factor erythroid 2 (NFE 2) - related factor 2 (NFE2L2 or NRF2) is one of the transcription factors predominantly related to the expression of antioxidant genes. NRF2 plays a pivotal role in controlling redox potential in several tumor characteristics, including cancer cell metabolism, stem-cell-like characteristics, tumor ...
Kanthesh M. Basalingappa +4 more
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Reactive Oxygen Species, 2019
Regulation of antioxidant gene expression is essential for controlling oxidative stress and maintaining physiological homeostasis. In this context, the nuclear factor E2-related factor 2 (Nrf2) has been identified as the chief regulator of the transcription of diverse antioxidant genes as well as many other cytoprotective genes.
Y. Li, Zhenquan Jia, Hong Zhu
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Regulation of antioxidant gene expression is essential for controlling oxidative stress and maintaining physiological homeostasis. In this context, the nuclear factor E2-related factor 2 (Nrf2) has been identified as the chief regulator of the transcription of diverse antioxidant genes as well as many other cytoprotective genes.
Y. Li, Zhenquan Jia, Hong Zhu
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Mechanism of the Nrf2/Keap1/ARE signaling system
Biochemistry (Moscow), 2011Nrf2 regulates expression of genes containing antioxidant-respons(iv)e element (ARE) in their promoters and plays a pivotal role among all redox-sensitive transcription factors. Nrf2 is constitutively controlled by repressor protein Keap1, which acts as a molecular sensor of disturbances in cellular homeostasis.
V O, Tkachev +2 more
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Nrf2—A regulator of keratinocyte redox signaling
Free Radical Biology and Medicine, 2015The skin is frequently exposed to environmental challenges, such as UV irradiation, toxic chemicals, and mechanical wounding. These insults cause an increase in the levels of reactive oxygen species, resulting in oxidative stress and concomitant inflammation, skin aging, and even cancer development.
Matthias Schäfer, Sabine Werner
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The Effects of Ginsenosides on the Nrf2 Signaling Pathway
2021Nuclear factor erythroid-2 related factor 2 (Nrf2) is a major signaling pathway for the maintenance of homeostasis and redox balance. This pathway also plays a significant role in proteostasis, xenobiotic/drug metabolism, apoptosis, and lipid and carbohydrate metabolism.
Ashrafizadeh, Milad +5 more
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Nrf2/ARE axis signalling in hepatocyte cellular death
Molecular Biology Reports, 2022The Nrf2-ARE transcriptional pathway plays an important role amongst cellular defence systems regulating and ensuring adequacy of redox responses and oxidant signalling factors. Hepatocyte cellular death and injury is a prominent feature underlying liver pathologies.
Bayan Y. Ghanim, Nidal A. Qinna
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Nrf2 Signaling in Viral Infections
Reactive Oxygen Species, 2022Nrf2 is a central regulator of cellular antioxidant and other cytoprotective genes. Several recent studies revealed a novel role for Nrf2 signaling in protecting against viral infections, including COVID-19. The findings from these studies pointed to a feasibility for treating viral infections, including COVID-19, via pharmacological activation of the ...
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Exercise-induced Nrf2-signaling is impaired in aging
Free Radical Biology and Medicine, 2016The transcription factor nuclear erythroid-2 like factor-2 (Nrf2) is the master regulator of antioxidant defense. Data from animal studies suggest exercise elicits significant increases in Nrf2 signaling, and that signaling is impaired with aging resulting in decreased induction of phase II detoxifying enzymes and greater susceptibility to oxidative ...
Tinna Traustadóttir, Matthew J Gage
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The Nrf2-Keap1/ARE signaling pathway in aquatic animals
International Journal of Biological MacromoleculesThe complex and fluctuating conditions of aquatic ecosystems make aquatic organisms vulnerable to oxidative stress. The Nrf2-Keap1/ARE signaling pathway serves as an important intracellular defense mechanism, particularly for aquatic organisms exposed to environmental stressors and toxic substances.
Qiu-Ning Liu +2 more
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