Results 81 to 90 of about 92,480 (295)

Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction [PDF]

, 2010
Abnormal lung inflammation and oxidant burden are associated with a significant reduction in histone deacetylase 2 (HDAC2) abundance and steroid resistance.
Adenuga, David, Hongwei Yao, Sangwoon Chung, Isaac K. Sundar, David Adenuga, Yao, Hongwei, Caito, Samuel, Jae-Woong Hwang, Sundar, Isaac K, Hwang, Jae-woong, Rahman, Irfan, Irfan Rahman, Chung, Sangwoon, Samuel Caito   +13 more
core   +1 more source

Crosstalk between Peroxisomal Activities and Nrf2 Signaling in Porcine Embryos

, 2021
Melatonin and phytanic acid (PA) are known to be involved in lipid metabolism and β-oxidation, in which peroxisomal activities also significantly participate.
Geon A. Kim, Kim, Eui-Hyun, Muhammad-Rosyid Ridlo, Ridlo, Muhammad-Rosyid, Lee, Byeong-Chun, Eui-Hyun Kim, Kim, Geon A., Byeong-Chun Lee   +7 more
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Keap1-Nrf2 pathway: a key mechanism in the occurrence and development of cancer

Frontiers in Oncology
The Keap1-Nrf2 signaling pathway is a major regulator of the cytoprotective response, participating in endogenous and exogenous stress caused by ROS (reactive oxygen species). Nrf2 is the core of this pathway.
Feilong Chen, Mei Xiao, Shaofan Hu, Meng Wang   +3 more
doaj   +1 more source

Glycocalyx sialic acids regulate Nrf2-mediated signaling by fluid shear stress in human endothelial cells

Redox Biology, 2021
Activation of the nuclear factor erythroid 2–related factor 2 (Nrf2) pathway is critical for vascular endothelial redox homeostasis in regions of high, unidirectional shear stress (USS), however the underlying mechanosensitive mediators are not fully ...
Paraskevi-Maria Psefteli, Phoebe Kitscha, Gema Vizcay, Roland Fleck, Sarah J. Chapple, Giovanni E. Mann, Mark Fowler, Richard C. Siow   +7 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Pseudomonas aeruginosa pyocyanin activates NRF2-ARE-mediated transcriptional response via the ROS-EGFR-PI3K-AKT/MEK-ERK MAP kinase signaling in pulmonary epithelial cells.

PLoS ONE, 2013
The redox-active pyocyanin (PCN) secreted by the respiratory pathogen Pseudomonas aeruginosa generates reactive oxygen species (ROS) and causes oxidative stress to pulmonary epithelial cells.
Ying Xu, Chaohui Duan, Zhizhou Kuang, Yonghua Hao, Jayme L Jeffries, Gee W Lau   +5 more
doaj   +1 more source

SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway

Cell Death and Disease, 2023
Cancer cells consistently utilize the unfolded protein response (UPR) to encounter the abnormal endoplasmic reticulum (ER) stress induced by the accumulation of misfolded proteins.
Lei Dong, Mengchuan Xu, Yang Li, Wanting Xu, Chengwei Wu, Hanfei Zheng, Zhenyu Xiao, Guochen Sun, Lei Ding, Xiaobo Li, Wenming Li, Liying Zhou, Qin Xia   +12 more
doaj   +1 more source

Nrf2 signaling pathway: current status and potential therapeutic targetable role in human cancers

Frontiers in Oncology, 2023
Cancer is a borderless global health challenge that continues to threaten human health. Studies have found that oxidative stress (OS) is often associated with the etiology of many diseases, especially the aging process and cancer.
Li Lin, Qing Wu, Feifei Lu, Jiaming Lei, Yanhong Zhou, Yifei Liu, Ni Zhu, You Yu, Zhifeng Ning, Tonghui She, Meichun Hu   +10 more
doaj   +1 more source