Results 61 to 70 of about 92,480 (295)

Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling. [PDF]

PLoS ONE, 2012
TGF-β plays a key role in the development of renal fibrosis. Suppressing the TGF-β signaling pathway is a possible therapeutic approach for preventing this disease, and reports have suggested that Nrf2 protects against renal fibrosis by inhibiting TGF-β ...
Chang Joo Oh, Joon-Young Kim, Young-Keun Choi, Han-Jong Kim, Ji-Yun Jeong, Kwi-Hyun Bae, Keun-Gyu Park, In-Kyu Lee   +7 more
doaj   +1 more source

Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism

iScience, 2023
Summary: Maintenance of redox balance plays central roles in a plethora of signaling processes. Although physiological levels of reactive oxygen and nitrogen species are crucial for functioning of certain signaling pathways, excessive production of free ...
Richa Tyagi, Suwarna Chakraborty, Sunil Jamuna Tripathi, Ik-Rak Jung, Sangwon F. Kim, Solomon H. Snyder, Bindu D. Paul   +6 more
doaj   +1 more source

Exploring the role of Nrf2 signaling in glioblastoma multiforme

Discover Oncology, 2022
AbstractGlioblastoma multiforme (GBM) is one of the most aggressive glial cell tumors in adults. Although current treatment options for GBM offer some therapeutic benefit, median survival remains poor and does not generally exceed 14 months. Several genes, such as isocitrate dehydrogenase (IDH) enzyme and O6-methylguanine-DNA methyltransferase (MGMT ...
Wireko Andrew Awuah, Abdul-Rahman Toufik, Rohan Yarlagadda, Tatiana Mikhailova, Aashna Mehta, Helen Huang, Mrinmoy Kundu, Leilani Lopes, Sylvester Benson, Lyndin Mykola, Sikora Vladyslav, Athanasios Alexiou, Badrah S. Alghamdi, Anwar M. Hashem, Ghulam Md Ashraf   +14 more
openaire   +3 more sources

The Role of the Nrf2 Signaling in Obesity and Insulin Resistance [PDF]

International Journal of Molecular Sciences, 2020
Obesity, a metabolic disorder characterized by excessive accumulation of adipose tissue, has globally become an increasingly prevalent disease. Extensive studies have been conducted to elucidate the underlying mechanism of the development of obesity.
Shiri Li, Natsuki Eguchi, Hien Lau, Hirohito Ichii   +3 more
openaire   +4 more sources

GSTA3 regulates TGF-1-induced renal interstitial fibrosis in NRK-52E cells as a component of the PI3K–Keap1/Nrf2 pathway

Journal of International Medical Research, 2019
Objective To evaluate the effect of GSTA3 within the PI3K–Keap1/Nrf2 pathway in renal interstitial fibrosis (RIF). Methods An in vitro RIF model with TGF-β1 stimulation in NRK-52E cells was established to identify potential signaling pathways that ...
Yun Xiao, Zhiwei Zhang, Yingyu Fu, Huizhi Shan, Sini Cui, Jun Wu   +5 more
doaj   +1 more source

Nrf2 regulates ROS production by mitochondria and NADPH oxidase.

, 2015
Nuclear factor (erythroid-derived 2) factor 2 (Nrf2) is a crucial transcription factor mediating protection against oxidants. Nrf2 is negatively regulated by cytoplasmic Kelch-like ECH associated protein 1 (Keap1) thereby providing inducible antioxidant ...
Dinkova-Kostova, AT, Holmström, Kira M., Stjepana Kovaca, Kovac, S, Plamena R. Angelovaa, Ying Zhangb, Andrey Y. Abramova, Abramov, Andrey Y., Angelova, PR, Zhang, Y, Abramov, AY, Angelova, Plamena R., Kovac, Stjepana, Zhang, Ying, Kira M. Holmströma, Holmström, KM, Dinkova-Kostova, Albena T.; id_orcid, Dinkova-Kostova, Albena T., Albena T   +18 more
core   +1 more source

Regulation of Keap1–Nrf2 signaling: The role of epigenetics [PDF]

Current Opinion in Toxicology, 2016
Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (NFE2L2/Nrf2) signaling pathway is a pivotal player in the antioxidant response to oxidative and electrophilic stress and can play a role in many human diseases.
David, Cheng, Renyi, Wu, Yue, Guo, Ah-Ng Tony, Kong   +3 more
openaire   +2 more sources

Molecular Basis of the KEAP1-NRF2 Signaling Pathway

Molecules and Cells, 2023
Transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of cellular responses against environmental stresses. NRF2 induces expression of detoxification and antioxidant enzymes and suppresses inductions of pro-inflammatory cytokine genes.
Takafumi Suzuki, Jun Takahashi, Masayuki Yamamoto   +2 more
openaire   +2 more sources

CPCGI Reduces Gray and White Matter Injury by Upregulating Nrf2 Signaling and Suppressing Calpain Overactivation in a Rat Model of Controlled Cortical Impact

Neuropsychiatric Disease and Treatment, 2020
Fei Niu,1,* Ke Qian,2,* Hongyan Qi,3 Yumei Zhao,4 Yingying Jiang,4 Wang Jia,2 Ming Sun4 1Department of Neurotrauma, Beijing Key Laboratory of Central Nervous System Injury, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070 ...
Niu F, Qian K, Qi H, Zhao Y, Jiang Y, Jia W, Sun M   +6 more
doaj  

Nuclear Import and Export Signals in Control of Nrf2 [PDF]

Journal of Biological Chemistry, 2005
Nrf2 binds to the antioxidant response element and regulates expression and antioxidant induction of a battery of chemopreventive genes. In this study, we have identified nuclear import and export signals of Nrf2 and show that the nuclear import and export of Nrf2 is regulated by antioxidants.
Abhinav K, Jain, David A, Bloom, Anil K, Jaiswal   +2 more
openaire   +3 more sources