Results 61 to 70 of about 92,684 (262)

Intersection of H2S and Nrf2 signaling: Therapeutic opportunities for neurodegenerative diseases

Neurotherapeutics
Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), represent a significant global health burden due to their progressive and debilitating nature.
Priyanka Soni, Shravan Paswan, Bindu D. Paul, Bobby Thomas   +3 more
doaj   +1 more source

KAT6A regulates stemness of aging bone marrow-derived mesenchymal stem cells through Nrf2/ARE signaling pathway

Stem Cell Research & Therapy, 2021
Background This study aimed to explore the effect of KAT6A on the decreased stemness of aging bone marrow-derived mesenchymal stem cells (BMSCs) and its potential mechanism.
Dongdong Fei, Yazheng Wang, Qiming Zhai, Xige Zhang, Yang Zhang, Yang Wang, Bei Li, Qintao Wang   +7 more
doaj   +1 more source

Anti-Osteoarthritis Mechanism of the Nrf2 Signaling Pathway

Biomedicines, 2023
Osteoarthritis (OA) is a chronic degenerative disease and the primary pathogenic consequence of OA is inflammation, which can affect a variety of tissues including the synovial membrane, articular cartilage, and subchondral bone. The development of the intra-articular microenvironment can be significantly influenced by the shift of synovial macrophages
Sarmistha Saha, Nazih Y. Rebouh
openaire   +4 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Systems Approach Reveals Nuclear Factor Erythroid 2-Related Factor 2/Protein Kinase R Crosstalk in Human Cutaneous Leishmaniasis

Frontiers in Immunology, 2017
Leishmania parasites infect macrophages, causing a wide spectrum of human diseases, from cutaneous to visceral forms. In search of novel therapeutic targets, we performed comprehensive in vitro and ex vivo mapping of the signaling pathways upstream and ...
Áislan de Carvalho Vivarini, Teresa Cristina Calegari-Silva, Alessandra Mattos Saliba, Viviane Sampaio Boaventura, Jaqueline França-Costa, Ricardo Khouri, Tim Dierckx, Karina Luiza Dias-Teixeira, Nicolas Fasel, Aldina Maria Prado Barral, Valéria Matos Borges, Johan Van Weyenbergh, Ulisses Gazos Lopes   +12 more
doaj   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

NRF2 and Primary Cilia: An Emerging Partnership

Antioxidants, 2020
When not dividing, many cell types target their centrosome to the plasma membrane, where it nucleates assembly of a primary cilium, an antenna-like signaling structure consisting of nine concentric microtubule pairs surrounded by membrane.
Ana Martin-Hurtado, Isabel Lastres-Becker, Antonio Cuadrado, Francesc R. Garcia-Gonzalo   +3 more
doaj   +1 more source

Advance in Nrf2 Signaling Pathway in Leishmaniasis

Biomedicines
One of the main components of innate defense against invasive parasites is oxidative stress, which is brought on by reactive oxygen species (ROS). On the other hand, oxidative stressors serve two purposes: free radicals aid in the elimination of pathogens, but they can also set off inflammation, which leads to tissue damage.
Sarmistha Saha, Nadezhda Sachivkina, Olga Kuznetsova, Ekaterina Neborak, Natallia Zhabo   +4 more
openaire   +3 more sources

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

Oxidative Medicine and Cellular Longevity, 2020
The Keap1/Nrf2/ARE system is a central defensive mechanism against oxidative stress which plays a key role in the pathogenesis and progression of many diseases. Nrf2 is a redox-sensitive transcription factor controlling a variety of downstream antioxidant and cytodefensive genes. Nrf2 has a powerful anti-inflammatory activity mediated via modulating NF-
Emad H. M. Hassanein, Ahmed M. Sayed, Omnia E. Hussein, Ayman M. Mahmoud   +3 more
openaire   +2 more sources

Exercise, Nrf2 and Antioxidant Signaling in Cardiac Aging [PDF]

Frontiers in Physiology, 2016
Aging is represented by a progressive decline in cellular functions. The age-related deformities in cardiac behaviors are the loss of cardiac myocytes through apoptosis or programmed cell death. Oxidative stress (OS) and its deleterious consequence contribute to age-related mechanical remodeling, reduced regenerative capacity, and apoptosis in cardiac ...
Narasimhan, Madhusudhanan, Rajasekaran, Namakkal S.   +1 more
openaire   +2 more sources