Results 61 to 70 of about 86,661 (246)
Nrf2 negatively regulates melanogenesis by modulating PI3K/Akt signaling.
PLoS ONE, 2014 Nrf2 plays a role in protection of cells against oxidative stress and xenobiotic damage by regulating cytoprotective genes. In this study, we investigated the effect of Nrf2 on melanogenesis in normal human melanocytes (NHMCs). When NHMCs were transduced
Jung-Min Shin +13 more
doaj +1 more source
Stem Cell Research & Therapy, 2021 Background This study aimed to explore the effect of KAT6A on the decreased stemness of aging bone marrow-derived mesenchymal stem cells (BMSCs) and its potential mechanism.
Dongdong Fei +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Keap1-Nrf2 pathway: a key mechanism in the occurrence and development of cancer
Frontiers in OncologyThe Keap1-Nrf2 signaling pathway is a major regulator of the cytoprotective response, participating in endogenous and exogenous stress caused by ROS (reactive oxygen species). Nrf2 is the core of this pathway.
Feilong Chen +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Intersection of H2S and Nrf2 signaling: Therapeutic opportunities for neurodegenerative diseases
NeurotherapeuticsNeurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), represent a significant global health burden due to their progressive and debilitating nature.
Priyanka Soni +3 more
doaj +1 more source
Frontiers in Immunology, 2017 Leishmania parasites infect macrophages, causing a wide spectrum of human diseases, from cutaneous to visceral forms. In search of novel therapeutic targets, we performed comprehensive in vitro and ex vivo mapping of the signaling pathways upstream and ...
Áislan de Carvalho Vivarini +12 more
doaj +1 more source
NRF2 and Primary Cilia: An Emerging Partnership
Antioxidants, 2020 When not dividing, many cell types target their centrosome to the plasma membrane, where it nucleates assembly of a primary cilium, an antenna-like signaling structure consisting of nine concentric microtubule pairs surrounded by membrane.
Ana Martin-Hurtado +3 more
doaj +1 more source
Advance in Nrf2 Signaling Pathway in Leishmaniasis
BiomedicinesOne of the main components of innate defense against invasive parasites is oxidative stress, which is brought on by reactive oxygen species (ROS). On the other hand, oxidative stressors serve two purposes: free radicals aid in the elimination of pathogens, but they can also set off inflammation, which leads to tissue damage.
Sarmistha Saha +4 more
openaire +3 more sources
Anti-Osteoarthritis Mechanism of the Nrf2 Signaling Pathway
Biomedicines, 2023 Osteoarthritis (OA) is a chronic degenerative disease and the primary pathogenic consequence of OA is inflammation, which can affect a variety of tissues including the synovial membrane, articular cartilage, and subchondral bone. The development of the intra-articular microenvironment can be significantly influenced by the shift of synovial macrophages
Sarmistha Saha, Nazih Y. Rebouh
openaire +4 more sources