Results 41 to 50 of about 92,684 (262)

Bioactive Compounds in Oxidative Stress-Mediated Diseases: Targeting the NRF2/ARE Signaling Pathway and Epigenetic Regulation

Antioxidants, 2021
Oxidative stress is a pathological condition occurring due to an imbalance between the oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 (NRF2), encoded by the gene NFE2L2, is the master regulator of phase II ...
Muthu Thiruvengadam, Baskar Venkidasamy, Umadevi Subramanian, Ramkumar Samynathan, Mohammad Ali Shariati, Maksim Rebezov, Shabari Girish, Sivakumar Thangavel, Anand Raj Dhanapal, Natalya Fedoseeva, Joohyun Lee, Ill-Min Chung   +11 more
doaj   +1 more source

GSTA3 regulates TGF-1-induced renal interstitial fibrosis in NRK-52E cells as a component of the PI3K–Keap1/Nrf2 pathway

Journal of International Medical Research, 2019
Objective To evaluate the effect of GSTA3 within the PI3K–Keap1/Nrf2 pathway in renal interstitial fibrosis (RIF). Methods An in vitro RIF model with TGF-β1 stimulation in NRK-52E cells was established to identify potential signaling pathways that ...
Yun Xiao, Zhiwei Zhang, Yingyu Fu, Huizhi Shan, Sini Cui, Jun Wu   +5 more
doaj   +1 more source

A novel Keap1 inhibitor iKeap1 activates Nrf2 signaling and ameliorates hydrogen peroxide-induced oxidative injury and apoptosis in osteoblasts

Cell Death and Disease, 2021
An ultra-large structure-based virtual screening has discovered iKeap1 as a direct Keap1 inhibitor that can efficiently activate Nrf2 signaling. We here tested its potential effect against hydrogen peroxide (H2O2)-induced oxidative injury in osteoblasts.
Yue-huan Zheng, Jian-jun Yang, Pei-jun Tang, Yuan Zhu, Zhe Chen, Chang She, Gang Chen, Peng Cao, Xiang-yang Xu   +8 more
doaj   +1 more source

Activation of NRF2 Signaling Pathway Delays the Progression of Hyperuricemic Nephropathy by Reducing Oxidative Stress

Antioxidants, 2023
Hyperuricemia (HUA)-induced oxidative stress is a crucial contributor to hyperuricemic nephropathy (HN), but the molecular mechanisms underlying the disturbed redox homeostasis in kidneys remain elusive.
Panshuang Qiao, Yi Sun, Yiming Wang, Simei Lin, Yongpan An, Liang Wang, Jihan Liu, Yajun Huang, Baoxue Yang, Hong Zhou   +9 more
doaj   +1 more source

CPCGI Reduces Gray and White Matter Injury by Upregulating Nrf2 Signaling and Suppressing Calpain Overactivation in a Rat Model of Controlled Cortical Impact

Neuropsychiatric Disease and Treatment, 2020
Fei Niu,1,* Ke Qian,2,* Hongyan Qi,3 Yumei Zhao,4 Yingying Jiang,4 Wang Jia,2 Ming Sun4 1Department of Neurotrauma, Beijing Key Laboratory of Central Nervous System Injury, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070 ...
Niu F, Qian K, Qi H, Zhao Y, Jiang Y, Jia W, Sun M   +6 more
doaj  

Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling. [PDF]

PLoS ONE, 2012
TGF-β plays a key role in the development of renal fibrosis. Suppressing the TGF-β signaling pathway is a possible therapeutic approach for preventing this disease, and reports have suggested that Nrf2 protects against renal fibrosis by inhibiting TGF-β ...
Chang Joo Oh, Joon-Young Kim, Young-Keun Choi, Han-Jong Kim, Ji-Yun Jeong, Kwi-Hyun Bae, Keun-Gyu Park, In-Kyu Lee   +7 more
doaj   +1 more source

Nrf2:INrf2 (Keap1) signaling in oxidative stress [PDF]

Free Radical Biology and Medicine, 2009
Nrf2:INrf2 (Keap1) are cellular sensors of chemical- and radiation-induced oxidative and electrophilic stress. Nrf2 is a nuclear transcription factor that controls the expression and coordinated induction of a battery of defensive genes encoding detoxifying enzymes and antioxidant proteins.
James W, Kaspar, Suryakant K, Niture, Anil K, Jaiswal   +2 more
openaire   +2 more sources

Nuclear Import and Export Signals in Control of Nrf2 [PDF]

Journal of Biological Chemistry, 2005
Nrf2 binds to the antioxidant response element and regulates expression and antioxidant induction of a battery of chemopreventive genes. In this study, we have identified nuclear import and export signals of Nrf2 and show that the nuclear import and export of Nrf2 is regulated by antioxidants.
Abhinav K, Jain, David A, Bloom, Anil K, Jaiswal   +2 more
openaire   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source