Results 41 to 50 of about 92,480 (295)
HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents [PDF]
, 2014 The NRF2 signalling cascade provides a primary response against electrophilic chemicals and oxidative stress. The activation of NRF2-signaling is anticipated to have adverse clinical consequences; NRF2 is activated in a number of cancers, additionally ...
A Kenneth MacLeod +17 more
core +1 more source
Targeting Nrf2 Signaling to Combat Chemoresistance [PDF]
Journal of Cancer Prevention, 2014 Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that upregulates expression of a battery of genes to combat oxidative and electrophilic stress. Modification of Kelch-like ECH-associated protein 1 (Keap1) by reactive oxygen species stabilizes Nrf2 by escaping from degradation.
No, Jae Hong +2 more
openaire +2 more sources
The emerging role of Nrf2 in mitochondrial function [PDF]
, 2015 The transcription factor NF-E2 p45-related factor 2 (Nrf2, gene name NFE2L2) allows adaptation and survival under conditions of stress by regulating the gene expression of diverse networks of cytoprotective proteins, including antioxidant, anti ...
Dinkova-Kostova, AT +4 more
core +1 more source
Interaction of saffron and its constituents with Nrf2 signaling pathway: A review [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Saffron (Crocus sativus) is a natural compound and its constituents such as crocin, crocetin, and safranal have many pharmacological properties such as anti-oxidant, anti-inflammatory, antitumor, antigenotoxic, anti-depressant, hepatoprotective ...
Arian Khoshandam +2 more
doaj +1 more source
Monitoring Keap1-Nrf2 interactions in single live cells [PDF]
, 2014 The transcription factor NF-E2 p45-related factor 2 (Nrf2) and its negative regulator Kelch-like ECH associated protein 1 (Keap1) control the expression of nearly 500 genes with diverse cytoprotective functions.
Dinkova-Kostova, Albena, T +5 more
core +1 more source
Mechanisms and functions of Nrf2 signaling in Drosophila [PDF]
Free Radical Biology and Medicine, 2015 The Nrf2 transcription factor belongs to the Cap'n'collar family, named after the founding member of this group, the product of the Drosophila Cap'n'collar gene. The encoded protein, Cap'n'collar, abbreviated Cnc, offers a convenient and accessible model to study the structure, function, and biology of Nrf2 transcription factors at the organismic ...
Andrew, Pitoniak, Dirk, Bohmann
openaire +2 more sources
Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells [PDF]
, 2012 Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key transcription factor regulating a plethora of detoxifying enzymes and antioxidant genes involved in drug metabolism and defence against oxidative stress.
Denise V. Kratschmar (165140) +35 more
core +1 more source
Frontiers in Pharmacology, 2023 Osteoarthritis (OA), a chronic joint cartilage disease, is characterized by the imbalanced homeostasis between anabolism and catabolism. Oxidative stress contributes to inflammatory responses, extracellular matrix (ECM) degradation, and chondrocyte ...
Zhenyu Wu +5 more
doaj +1 more source
Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration [PDF]
, 2013 Transcription factor Nrf2 and its repressor Keap1 regulate a network of cytoprotective genes involving more than 1% of the genome, their best known targets being drug-metabolizing and antioxidant genes.
Iain Hargreaves +29 more
core +1 more source
Chemical tuning enhances both potency toward Nrf2 and in vitro therapeutic index of triterpenoids [PDF]
, 2014 The transcription factor Nrf2 protects against a number of experimental pathologies, and is a promising therapeutic target. The clinical investigation of a potent Nrf2-inducing agent, the triterpenoid (TP) bardoxolone methyl (BARD), was recently halted ...
Lister, Adam +10 more
core +1 more source