Results 21 to 30 of about 86,661 (246)
Biology, 2023 Nuclear factor (erythroid-derived 2)-like 2 (NRF2), well-known as a master antioxidative response regulator in mammalian cells, is considered as a potential target for radiation protection and cancer therapy sensitization.
Jun Wang +2 more
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NRF2 negatively regulates primary ciliogenesis and hedgehog signaling.
PLoS Biology, 2020 Primary cilia are lost during cancer development, but the mechanism regulating cilia degeneration is not determined. While transcription factor nuclear factor-erythroid 2-like 2 (NRF2) protects cells from oxidative, proteotoxic, and metabolic stress in ...
Pengfei Liu +4 more
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Modulation of NRF2/KEAP1 Signaling in Preeclampsia
Cells, 2023 Placentation is a key and tightly regulated process that ensures the normal development of the placenta and fetal growth. Preeclampsia (PE) is a hypertensive pregnancy-related disorder involving about 5–8% of all pregnancies and clinically characterized by de novo maternal hypertension and proteinuria. In addition, PE pregnancies are also characterized
Giovanni Tossetta +6 more
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Frontiers in Aging Neuroscience, 2022 Nuclear factor erythroid-2-related factor 2 (Nrf2) is a pleiotropic transcription factor, and it has been documented that it can induce defense mechanisms both oxidative stress and inflammatory injury.
Tianqi Jiang, Tianqi Jiang, Yongxiong He
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Targeting NRF2 signaling for cancer chemoprevention [PDF]
Toxicology and Applied Pharmacology, 2010 Modulation of the metabolism and disposition of carcinogens through induction of cytoprotective enzymes is one of several promising strategies to prevent cancer. Chemopreventive efficacies of inducers such as dithiolethiones and sulforaphane have been extensively studied in animals as well as in humans.
Mi-Kyoung, Kwak, Thomas W, Kensler
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Brain Disorders, 2021 The nuclear factor erythroid 2-related factor (Nrf2) transcription factor/Hemoxygenase 1 (HO-1) is a primary regulator of essential cytoprotective responses in the brain.
Shubham Upadhayay +1 more
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Targeting Nrf2 Signaling to Combat Chemoresistance [PDF]
Journal of Cancer Prevention, 2014 Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that upregulates expression of a battery of genes to combat oxidative and electrophilic stress. Modification of Kelch-like ECH-associated protein 1 (Keap1) by reactive oxygen species stabilizes Nrf2 by escaping from degradation.
No, Jae Hong +2 more
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Cancer Medicine, 2023 Background Lung squamous cell carcinoma (LUSC) currently has limited therapeutic options because of the relatively few validated targets and the lack of clinical drugs for some of these targets.
Lili Ji +6 more
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Journal of Pharmacological Sciences, 2021 Pentagalloylglucose (PGG), a gallotannin polyphenolic compound, has been found to possess a host of beneficial pharmacologic activities, such as anti-inflammatory and antioxidative activities.
Jinzhi Tong +9 more
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Keap1–Nrf2 signalling in pancreatic cancer [PDF]
The International Journal of Biochemistry & Cell Biology, 2015 Transcription factor NF-E2 p45-related factor 2 (Nrf2, also called Nfe2l2), a master regulator of redox homeostasis, and its dominant negative regulator, Kelch-like ECH-associated protein 1 (Keap1), together tightly control the expression of numerous detoxifying and antioxidant genes.
Alastair J, Hayes +3 more
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