Results 1 to 10 of about 92,480 (295)
Melatonin-Nrf2 Signaling Activates Peroxisomal Activities in Porcine Cumulus Cell-Oocyte Complexes
Antioxidants, 2020 Melatonin and Nrf2 signaling synergistically improve mammalian oocyte maturation and embryonic development. Furthermore, previous studies have suggested an interplay between peroxisomes and Nrf2 signaling in cells, but it is still unclear whether ...
Eui Hyun Kim +3 more
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Cells, 2021 The oxidative-stress-induced impairment of autophagy plays a critical role in the pathogenesis of Parkinson’s disease (PD). In this study, we investigated whether the alteration of Nrf2 in astrocytes protected against 6-OHDA (6-hydroxydopamine)- and ...
Qing Guo +5 more
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The potential roles of Nrf2/Keap1 signaling in anticancer drug interactions
Current Research in Pharmacology and Drug Discovery, 2021 Nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), together with its suppressive binding partner Kelch-like ECH-associated protein 1 (Keap1), regulates cellular antioxidant response and drug metabolism. The roles of Nrf2/Keap1 signaling in the
Jingya Wang +5 more
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Antioxidants, 2021 Doxorubicin (DOX) is extensively applied in cancer therapy due to its efficacy in suppressing cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent has been frequently used for cancer therapy, leading to ...
Sepideh Mirzaei +11 more
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Therapeutic Agents Targeting the Nrf2 Signaling Pathway to Combat Oxidative Stress and Intestinal Inflammation in Veterinary and Translational Medicine [PDF]
Veterinary SciencesThis review synthesizes research on nuclear factor erythroid 2-related factor 2 (Nrf2) in intestinal health across human, livestock, and mouse models.
Muhammad Zahoor Khan +9 more
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Simvastatin reduces high uric acid-induced oxidative stress and inflammatory response in vascular endothelial cells via nuclear factor E2-related factor 2 (Nrf2) signaling [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Increased oxidative stress and inflammatory response are risk factors for kidney and cardiovascular diseases in patients with hyperuricemia.
Xuemeng Chen, Li Xie, Wei Wu
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Nrf2 modulates the benefits of evening exercise in type 2 diabetes
Sports Medicine and Health Science, 2023 Exercise has well-characterized therapeutic benefits in the management of type 2 diabetes mellitus (T2DM). Most of the beneficial effects of exercise arise from the impact of nuclear factor erythroid 2 related factor-2 (Nrf2) activation of glucose ...
Babatunde Fasipe, Ismail Laher
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Z-REX uncovers a bifurcation in function of Keap1 paralogs
eLife, 2022 Studying electrophile signaling is marred by difficulties in parsing changes in pathway flux attributable to on-target, vis-à-vis off-target, modifications.
Alexandra Van Hall-Beauvais +8 more
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Frontiers in Pharmacology, 2021 Oxidative stress and oxidative damage are the common pathophysiological characteristics in pituitary adenomas (PAs), which have been confirmed with many omics studies in PA tissues and cell/animal experimental studies.
Xianquan Zhan +6 more
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European Journal of Cell Biology, 2021 Epithelial-mesenchymal transition (EMT) is a cellular process by which epithelial cells transform to acquire mesenchymal phenotypes. Accumulating evidence indicate the involvement of EMT in the progression of malignant diseases.
Kai Yazaki +9 more
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