Results 11 to 20 of about 92,480 (295)
Modulation of NRF2/KEAP1 Signaling in Preeclampsia [PDF]
Cells, 2023 Placentation is a key and tightly regulated process that ensures the normal development of the placenta and fetal growth. Preeclampsia (PE) is a hypertensive pregnancy-related disorder involving about 5-8% of all pregnancies and clinically characterized ...
Piani, Federica +13 more
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NRF2 negatively regulates primary ciliogenesis and hedgehog signaling.
PLoS Biology, 2020 Primary cilia are lost during cancer development, but the mechanism regulating cilia degeneration is not determined. While transcription factor nuclear factor-erythroid 2-like 2 (NRF2) protects cells from oxidative, proteotoxic, and metabolic stress in ...
Pengfei Liu +4 more
doaj +2 more sources
Epigenetic regulation of Keap1-Nrf2 signaling [PDF]
Free Radical Biology and Medicine, 2015 The kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) signaling axis serves as a "master regulator" in response to oxidative/electrophilic stresses and chemical insults through the coordinated ...
Yu, Siwang +7 more
core +3 more sources
Nrf2 negatively regulates melanogenesis by modulating PI3K/Akt signaling.
PLoS ONE, 2014 Nrf2 plays a role in protection of cells against oxidative stress and xenobiotic damage by regulating cytoprotective genes. In this study, we investigated the effect of Nrf2 on melanogenesis in normal human melanocytes (NHMCs). When NHMCs were transduced
Jung-Min Shin +13 more
doaj +2 more sources
Targeting Nrf2 signaling in dry eye [PDF]
International Journal of OphthalmologyDry eye, the most common ocular surface disease, can cause ocular surface tissue damage and discomfort symptoms and seriously affect people's quality of life. The etiology of dry eye is diverse, and its pathogenesis is complex.
Yu-Nuo Zhang +3 more
doaj +3 more sources
Neuronal activity regulates astrocytic Nrf2 signaling. [PDF]
Proceedings of the National Academy of Sciences, 2013 Nuclear factor erythroid 2-related factor 2 (Nrf2), the transcriptional master regulator of the stress-induced antioxidant response, plays a key role in neuronal resistance to oxidative stress and glutamate-induced excitotoxicity.
Wang, Xianhong +3 more
core +7 more sources
The Effects of Ginsenosides on the Nrf2 Signaling Pathway
, 2021 Nuclear factor erythroid-2 related factor 2 (Nrf2) is a major signaling pathway for the maintenance of homeostasis and redox balance. This pathway also plays a significant role in proteostasis, xenobiotic/drug metabolism, apoptosis, and lipid and ...
Amirhossein Sahebkar +11 more
core +4 more sources
Advance in Nrf2 Signaling Pathway in Leishmaniasis
BiomedicinesOne of the main components of innate defense against invasive parasites is oxidative stress, which is brought on by reactive oxygen species (ROS).
Olga Kuznetsova +4 more
core +4 more sources
Oxidative stress response and Nrf2 signaling in aging [PDF]
Free Radical Biology and Medicine, 2015 Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety of age-related pathologies. In aging, oxidant production from several sources is increased, whereas antioxidant enzymes, the primary lines of defense, are ...
Zhang, Hongqiao +5 more
core +6 more sources
Intersection of H2S and Nrf2 signaling: Therapeutic opportunities for neurodegenerative diseases
NeurotherapeuticsNeurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), represent a significant global health burden due to their progressive and debilitating nature.
Priyanka Soni +3 more
doaj +2 more sources