Results 11 to 20 of about 92,684 (262)
Targeting Nrf2 signaling in dry eye [PDF]
International Journal of OphthalmologyDry eye, the most common ocular surface disease, can cause ocular surface tissue damage and discomfort symptoms and seriously affect people's quality of life. The etiology of dry eye is diverse, and its pathogenesis is complex.
Yu-Nuo Zhang +3 more
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NRF2 signaling in cytoprotection and metabolism
British Journal of Pharmacology, 2023 The KEAP1-NRF2 system plays a central role in cytoprotection and defense mechanisms against oxidative stress. Because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and because NRF2 is a transcriptional factor regulating genes involved in the sulfur-mediated redox reactions, the KEAP1-NRF2 system has been regarded as a ...
Shohei Murakami +4 more
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Keap1/Nrf2 Signaling Pathway [PDF]
Antioxidants, 2021 Nuclear factor, erythroid 2-like transcription factor 2 (Nrf2) and its cytoplasmic inhibitor, kelch-like ECH-associated protein 1 (Keap1), comprise a redox-responsive endogenous antioxidant defense module that orchestrates the expression of cytoprotective genes to maintain homeostasis [...]
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Nrf2 Signaling in Macrophages [PDF]
Reactive Oxygen Species, 2016 The nuclear factor E2-related factor 2 (Nrf2) is known as the chief regulator of cellular antioxidant defenses as well as a suppressor of inflammation. Macrophages act as major players in inflammatory responses. Because oxidative stress and inflammation are two intertwined processes, the anti-inflammatory activity of Nrf2 signaling is believed to ...
Hong, Zhu, Zhenquan, Jia, Y Robert, Li
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Nrf2 signaling and cell survival [PDF]
Toxicology and Applied Pharmacology, 2010 Nrf2:INrf2 acts as a sensor for oxidative/electrophilic stress. INrf2 serves as an adaptor to link Nrf2 to the ubiquitin ligase Cul3-Rbx1 complex that ubiquitinate and degrade Nrf2. Under basal conditions, cytosolic INrf2/Cul3-Rbx1 is constantly degrading Nrf2.
Suryakant K, Niture +3 more
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Modulation of NRF2/KEAP1 Signaling in Preeclampsia
Cells, 2023 Placentation is a key and tightly regulated process that ensures the normal development of the placenta and fetal growth. Preeclampsia (PE) is a hypertensive pregnancy-related disorder involving about 5–8% of all pregnancies and clinically characterized by de novo maternal hypertension and proteinuria. In addition, PE pregnancies are also characterized
Giovanni Tossetta +6 more
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The Role of Toxic Metals and Metalloids in Nrf2 Signaling [PDF]
Antioxidants, 2021 Nuclear factor erythroid 2-related factor 2 (Nrf2), an emerging regulator of cellular resistance to oxidants, serves as one of the key defensive factors against a range of pathological processes such as oxidative damage, carcinogenesis, as well as various harmful chemicals, including metals.
Aleksandra Buha +6 more
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NRF2 Enables EGFR Signaling in Melanoma Cells [PDF]
International Journal of Molecular Sciences, 2021 Receptor tyrosine kinases (RTK) are rarely mutated in cutaneous melanoma, but the expression and activation of several RTK family members are associated with a proinvasive phenotype and therapy resistance. Epidermal growth factor receptor (EGFR) is a member of the RTK family and is only expressed in a subgroup of melanomas with poor prognosis.
Julia Katharina Charlotte Kreß +4 more
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Therapeutic Targeting of the NRF2 Signaling Pathway in Cancer [PDF]
Molecules, 2021 Cancer is one of the most fatal diseases with an increasing incidence and mortality all over the world. Thus, there is an urgent need for novel therapies targeting major cancer-related pathways. Nuclear factor-erythroid 2-related factor 2 (NRF2) and its major negative modulator Kelch-like ECH-associated protein 1 (KEAP1) are main players of the ...
Pelin Telkoparan-Akillilar +4 more
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Keap1–Nrf2 signalling in pancreatic cancer [PDF]
The International Journal of Biochemistry & Cell Biology, 2015 Transcription factor NF-E2 p45-related factor 2 (Nrf2, also called Nfe2l2), a master regulator of redox homeostasis, and its dominant negative regulator, Kelch-like ECH-associated protein 1 (Keap1), together tightly control the expression of numerous detoxifying and antioxidant genes.
Alastair J, Hayes +3 more
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