Results 31 to 40 of about 92,480 (295)
Crosstalk between Nrf2 and Notch signaling [PDF]
Free Radical Biology and Medicine, 2015 The transcription factor Nrf2 (nuclear factor, erythroid derived 2, like 2) belongs to the CNC-bZip protein family, forming a transcriptosome with its direct heterodimer partner, sMaf, and co-factors such as CBP/p300. Nrf2 binds to one or more AREs (antioxidant response elements) that are located in the gene regulatory regions of the hundreds of Nrf2 ...
Nobunao Wakabayashi +2 more
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NRF2 Enables EGFR Signaling in Melanoma Cells [PDF]
International Journal of Molecular Sciences, 2021 Receptor tyrosine kinases (RTK) are rarely mutated in cutaneous melanoma, but the expression and activation of several RTK family members are associated with a proinvasive phenotype and therapy resistance. Epidermal growth factor receptor (EGFR) is a member of the RTK family and is only expressed in a subgroup of melanomas with poor prognosis.
Julia Katharina Charlotte Kreß +4 more
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Monitoring the Antioxidant Mediated Chemosensitization and ARE-Signaling in Triple Negative Breast Cancer Therapy. [PDF]
PLoS ONE, 2015 Chemotherapy often fails due to cellular detoxifying mechanisms, including phase-II enzymes. Activation of Nrf2-Keap1 pathway induces phase-II enzymes expression through ARE-signaling and prevents cancer development.
Kira Foygel +2 more
doaj +1 more source
Biology, 2023 Nuclear factor (erythroid-derived 2)-like 2 (NRF2), well-known as a master antioxidative response regulator in mammalian cells, is considered as a potential target for radiation protection and cancer therapy sensitization.
Jun Wang +2 more
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p62 links autophagy and Nrf2 signaling [PDF]
Free Radical Biology and Medicine, 2015 The Nrf2-Keap1-ARE pathway is a redox and xenobiotic sensitive signaling axis that functions to protect cells against oxidative stress, environmental toxicants, and harmful chemicals through the induction of cytoprotective genes. To enforce strict regulation, cells invest a great deal of energy into the maintenance of the Nrf2 pathway to ensure rapid ...
Tao, Jiang +5 more
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Frontiers in Aging Neuroscience, 2022 Nuclear factor erythroid-2-related factor 2 (Nrf2) is a pleiotropic transcription factor, and it has been documented that it can induce defense mechanisms both oxidative stress and inflammatory injury.
Tianqi Jiang, Tianqi Jiang, Yongxiong He
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Journal of Pharmacological Sciences, 2021 Pentagalloylglucose (PGG), a gallotannin polyphenolic compound, has been found to possess a host of beneficial pharmacologic activities, such as anti-inflammatory and antioxidative activities.
Jinzhi Tong +9 more
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Targeting NRF2 signaling for cancer chemoprevention [PDF]
Toxicology and Applied Pharmacology, 2010 Modulation of the metabolism and disposition of carcinogens through induction of cytoprotective enzymes is one of several promising strategies to prevent cancer. Chemopreventive efficacies of inducers such as dithiolethiones and sulforaphane have been extensively studied in animals as well as in humans.
Mi-Kyoung, Kwak, Thomas W, Kensler
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Brain Disorders, 2021 The nuclear factor erythroid 2-related factor (Nrf2) transcription factor/Hemoxygenase 1 (HO-1) is a primary regulator of essential cytoprotective responses in the brain.
Shubham Upadhayay +1 more
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Cancer Medicine, 2023 Background Lung squamous cell carcinoma (LUSC) currently has limited therapeutic options because of the relatively few validated targets and the lack of clinical drugs for some of these targets.
Lili Ji +6 more
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