Results 31 to 40 of about 86,661 (246)
The KEAP1/NRF2 Signaling Pathway in Keratinization
Antioxidants, 2020 Keratinization is a tissue adaptation, but aberrant keratinization is associated with skin disorders such as ichthyoses, atopic dermatitis, psoriasis, and acne. The disease phenotype stems from the interaction between genes and the environment; therefore, an understanding of the adaptation machinery may lead to a new appreciation of pathomechanisms ...
Yosuke Ishitsuka +2 more
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Mechanisms and functions of Nrf2 signaling in Drosophila [PDF]
Free Radical Biology and Medicine, 2015 The Nrf2 transcription factor belongs to the Cap'n'collar family, named after the founding member of this group, the product of the Drosophila Cap'n'collar gene. The encoded protein, Cap'n'collar, abbreviated Cnc, offers a convenient and accessible model to study the structure, function, and biology of Nrf2 transcription factors at the organismic ...
Andrew, Pitoniak, Dirk, Bohmann
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Epigenetic regulation of Keap1-Nrf2 signaling [PDF]
Free Radical Biology and Medicine, 2015 The kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) signaling axis serves as a "master regulator" in response to oxidative/electrophilic stresses and chemical insults through the coordinated induction of a wide array of cytoprotective genes.
Yue, Guo +3 more
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Interaction of saffron and its constituents with Nrf2 signaling pathway: A review [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Saffron (Crocus sativus) is a natural compound and its constituents such as crocin, crocetin, and safranal have many pharmacological properties such as anti-oxidant, anti-inflammatory, antitumor, antigenotoxic, anti-depressant, hepatoprotective ...
Arian Khoshandam +2 more
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Frontiers in Pharmacology, 2023 Osteoarthritis (OA), a chronic joint cartilage disease, is characterized by the imbalanced homeostasis between anabolism and catabolism. Oxidative stress contributes to inflammatory responses, extracellular matrix (ECM) degradation, and chondrocyte ...
Zhenyu Wu +5 more
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Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling [PDF]
The EMBO Journal, 2006 Keap1 is a BTB-Kelch substrate adaptor protein that regulates steady-state levels of Nrf2, a bZIP transcription factor, in response to oxidative stress. We have determined the structure of the Kelch domain of Keap1 bound to a 16-mer peptide from Nrf2 containing a highly conserved DxETGE motif.
Shih-Ching, Lo +4 more
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Grub polypeptide extracts protect against oxidative stress through the NRF2-ARE signaling pathway
Animal Cells and Systems, 2021 Grub polypeptide extracts (GPEs) have antioxidant effects; however, their underlying molecular mechanisms are unknown. This study explored the antioxidant molecular mechanism of GPE via the nuclear factor-erythroid 2-related factor 2 (NRF2)-antioxidant ...
Jingyang Chen +4 more
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The Role of the Nrf2 Signaling in Obesity and Insulin Resistance [PDF]
International Journal of Molecular Sciences, 2020 Obesity, a metabolic disorder characterized by excessive accumulation of adipose tissue, has globally become an increasingly prevalent disease. Extensive studies have been conducted to elucidate the underlying mechanism of the development of obesity.
Shiri Li +3 more
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Antioxidants, 2021 Doxorubicin (DOX) is extensively applied in cancer therapy due to its efficacy in suppressing cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent has been frequently used for cancer therapy, leading to ...
Sepideh Mirzaei +11 more
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Oxidative Stress and Vitiligo: The Nrf2–ARE Signaling Connection [PDF]
Journal of Investigative Dermatology, 2014 Hypersensitivity of epidermal melanocytes to oxidative stress is known to contribute to vitiligo pathogenesis. Molecular mechanisms that connect melanocyte redox homeostasis to the complex disease phenotype are not fully understood. Jian et al. show that vitiligo melanocytes have impaired nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant ...
Qiu, Lei +2 more
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