Results 51 to 60 of about 92,480 (295)

Grub polypeptide extracts protect against oxidative stress through the NRF2-ARE signaling pathway

Animal Cells and Systems, 2021
Grub polypeptide extracts (GPEs) have antioxidant effects; however, their underlying molecular mechanisms are unknown. This study explored the antioxidant molecular mechanism of GPE via the nuclear factor-erythroid 2-related factor 2 (NRF2)-antioxidant ...
Jingyang Chen, Yingjian Sun, Shan Huang, Hong Shen, Yongjie Chen   +4 more
doaj   +1 more source

Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes, but not with insulin resistance [PDF]

, 2014
Mice lacking transcription factor NF-E2 p45-related factor 2 (Nrf2) develop more severe non-alcoholic steatohepatitis (NASH), with cirrhosis, than wild-type (Nrf2(+/+)) mice when fed a high-fat (HF) diet for 24 weeks.
Chowdhry, Sudhir, McCrimmon, Rory J.; id_orcid, Meakin, Paul J.; id_orcid, Dinkova-Kostova, AT, Meakin, PJ, Ashford, FB, Walsh, Shaun V., Chowdhry, S, Sharma, Ritu S., Walsh, SV, Ashford, Fiona B., Sharma, RS, Dillon, JF, Dillon, John F.; id_orcid, Hayes, John D, Hayes, JD, Dinkova-Kostova, Albena T.; id_orcid, Ashford, MLJ, Ashford, Michael L. J.; id_orcid, McCrimmon, RJ   +19 more
core   +1 more source

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling [PDF]

The EMBO Journal, 2006
Keap1 is a BTB-Kelch substrate adaptor protein that regulates steady-state levels of Nrf2, a bZIP transcription factor, in response to oxidative stress. We have determined the structure of the Kelch domain of Keap1 bound to a 16-mer peptide from Nrf2 containing a highly conserved DxETGE motif.
Shih-Ching, Lo, Xuchu, Li, Michael T, Henzl, Lesa J, Beamer, Mark, Hannink   +4 more
openaire   +2 more sources

NRF2 and the Moirai: Life and Death Decisions on Cell Fates.

, 2023
Significance: The transcription factor NRF2 (NF-E2-related factor 2) plays an important role as a master regulator of the cellular defense system by activating transcriptional programs of NRF2 target genes encoding multiple enzymes related to cellular ...
Yagishita, Y., Chartoumpekis, D.V., Wakabayashi, N., Kensler, T.W.   +3 more
core   +1 more source

Environmental toxicity, redox signaling and lung inflammation:the role of glutathione [PDF]

, 2009
Glutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress.
Saibal K. Biswas, Biswas, Saibal K, Rahman, Irfan, Irfan Rahman   +3 more
core   +1 more source

Bioactive Compounds in Oxidative Stress-Mediated Diseases: Targeting the NRF2/ARE Signaling Pathway and Epigenetic Regulation

Antioxidants, 2021
Oxidative stress is a pathological condition occurring due to an imbalance between the oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 (NRF2), encoded by the gene NFE2L2, is the master regulator of phase II ...
Muthu Thiruvengadam, Baskar Venkidasamy, Umadevi Subramanian, Ramkumar Samynathan, Mohammad Ali Shariati, Maksim Rebezov, Shabari Girish, Sivakumar Thangavel, Anand Raj Dhanapal, Natalya Fedoseeva, Joohyun Lee, Ill-Min Chung   +11 more
doaj   +1 more source

Oxidative Stress and Vitiligo: The Nrf2–ARE Signaling Connection [PDF]

Journal of Investigative Dermatology, 2014
Hypersensitivity of epidermal melanocytes to oxidative stress is known to contribute to vitiligo pathogenesis. Molecular mechanisms that connect melanocyte redox homeostasis to the complex disease phenotype are not fully understood. Jian et al. show that vitiligo melanocytes have impaired nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant ...
Qiu, Lei, Song, Zhiqi, Setaluri, Vijayasaradhi   +2 more
openaire   +2 more sources

Activation of NRF2 Signaling Pathway Delays the Progression of Hyperuricemic Nephropathy by Reducing Oxidative Stress

Antioxidants, 2023
Hyperuricemia (HUA)-induced oxidative stress is a crucial contributor to hyperuricemic nephropathy (HN), but the molecular mechanisms underlying the disturbed redox homeostasis in kidneys remain elusive.
Panshuang Qiao, Yi Sun, Yiming Wang, Simei Lin, Yongpan An, Liang Wang, Jihan Liu, Yajun Huang, Baoxue Yang, Hong Zhou   +9 more
doaj   +1 more source

Role of NRF2 in Lung Cancer

, 2021
The gene expression program induced by NRF2 transcription factor plays a critical role in cell defense responses against a broad variety of cellular stresses, most importantly oxidative stress.
Ana Clara Carrera, Miriam Sánchez-Ortega, Antonio Garrido   +2 more
core   +1 more source

A novel Keap1 inhibitor iKeap1 activates Nrf2 signaling and ameliorates hydrogen peroxide-induced oxidative injury and apoptosis in osteoblasts

Cell Death and Disease, 2021
An ultra-large structure-based virtual screening has discovered iKeap1 as a direct Keap1 inhibitor that can efficiently activate Nrf2 signaling. We here tested its potential effect against hydrogen peroxide (H2O2)-induced oxidative injury in osteoblasts.
Yue-huan Zheng, Jian-jun Yang, Pei-jun Tang, Yuan Zhu, Zhe Chen, Chang She, Gang Chen, Peng Cao, Xiang-yang Xu   +8 more
doaj   +1 more source