Results 51 to 60 of about 86,661 (246)

PI3K-AKT Signaling via Nrf2 Protects against Hyperoxia-Induced Acute Lung Injury, but Promotes Inflammation Post-Injury Independent of Nrf2 in Mice.

PLoS ONE, 2015
Lung epithelial and endothelial cell death accompanied by inflammation contributes to hyperoxia-induced acute lung injury (ALI). Impaired resolution of ALI can promote and/or perpetuate lung pathogenesis, including fibrosis.
Narsa M Reddy, Haranatha R Potteti, Suryanarayana Vegiraju, Hsin-Jou Chen, Chandra Mohan Tamatam, Sekhar P Reddy   +5 more
doaj   +1 more source

Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer

Journal of Hematology & Oncology, 2016
Background The objective of this study was to evaluate the effect of platinum-based drugs on nuclear-factor erythroid2 like 2 (NRF2) signaling in non-small cell lung cancer cell lines with or without Kelch-like ECH-associated protein 1 (KEAP1) mutations ...
Yijun Tian, Kongming Wu, Qian Liu, Na Han, Li Zhang, Qian Chu, Yuan Chen   +6 more
doaj   +1 more source

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

Oxidative Medicine and Cellular Longevity, 2020
The Keap1/Nrf2/ARE system is a central defensive mechanism against oxidative stress which plays a key role in the pathogenesis and progression of many diseases. Nrf2 is a redox-sensitive transcription factor controlling a variety of downstream antioxidant and cytodefensive genes. Nrf2 has a powerful anti-inflammatory activity mediated via modulating NF-
Emad H. M. Hassanein, Ahmed M. Sayed, Omnia E. Hussein, Ayman M. Mahmoud   +3 more
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism

iScience, 2023
Summary: Maintenance of redox balance plays central roles in a plethora of signaling processes. Although physiological levels of reactive oxygen and nitrogen species are crucial for functioning of certain signaling pathways, excessive production of free ...
Richa Tyagi, Suwarna Chakraborty, Sunil Jamuna Tripathi, Ik-Rak Jung, Sangwon F. Kim, Solomon H. Snyder, Bindu D. Paul   +6 more
doaj   +1 more source

Nrf2:INrf2 (Keap1) signaling in oxidative stress [PDF]

Free Radical Biology and Medicine, 2009
Nrf2:INrf2 (Keap1) are cellular sensors of chemical- and radiation-induced oxidative and electrophilic stress. Nrf2 is a nuclear transcription factor that controls the expression and coordinated induction of a battery of defensive genes encoding detoxifying enzymes and antioxidant proteins.
James W, Kaspar, Suryakant K, Niture, Anil K, Jaiswal   +2 more
openaire   +2 more sources

Molecular Basis of the KEAP1-NRF2 Signaling Pathway

Molecules and Cells, 2023
Transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of cellular responses against environmental stresses. NRF2 induces expression of detoxification and antioxidant enzymes and suppresses inductions of pro-inflammatory cytokine genes.
Takafumi Suzuki, Jun Takahashi, Masayuki Yamamoto   +2 more
openaire   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Nuclear Import and Export Signals in Control of Nrf2 [PDF]

Journal of Biological Chemistry, 2005
Nrf2 binds to the antioxidant response element and regulates expression and antioxidant induction of a battery of chemopreventive genes. In this study, we have identified nuclear import and export signals of Nrf2 and show that the nuclear import and export of Nrf2 is regulated by antioxidants.
Abhinav K, Jain, David A, Bloom, Anil K, Jaiswal   +2 more
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source