Results 141 to 150 of about 112,785 (303)

Phenotypic and functional characterization of corneal endothelial cells during in vitro expansion. [PDF]

, 2020
The advent of cell culture-based methods for the establishment and expansion of human corneal endothelial cells (CEnC) has provided a source of transplantable corneal endothelium, with a significant potential to challenge the one donor-one recipient ...
Aldave, Anthony J, Azimov, Rustam, Boere, Payton M, Chung, Doug D, Frausto, Ricardo F, George, Benjamin L, Hanser, E Maryam, Kao, Liyo, Kurtz, Ira, Mehta, Jodhbir S, Morselli, Marco, Peh, Gary SL, Pellegrini, Matteo, Swamy, Vinay S, Wu, Jessica   +14 more
core  

SIRT1 Prevents Ferroptosis in Corneal Epithelial Cells by Enhancing HIF1α Protein Stability in Dry Eye Disease

Advanced Science, EarlyView.
Hyperosmotic stress drives ferroptosis in corneal epithelium via SIRT1 downregulation. This work demonstrates that SIRT1 activation stabilizes HIF1α, which transcriptionally upregulates GPX4 to inhibit lipid peroxidation and cell death. The identified SIRT1/HIF1α/GPX4 axis reveals a novel defense mechanism and potential therapy for dry eye disease ...
Lili Lian, Zhenmin Le, Xuanqiao Ye, Zimo Wang, Jiuxiao Li, Chenyu Dong, Yetao Shen, Jiazheng Li, Yueping Ren, Xiaoyin Ma, Wei Chen, Qinxiang Zheng   +11 more
wiley   +1 more source

Mononuclear cell transcriptome changes associated with dimethyl fumarate in MS. [PDF]

, 2018
ObjectiveTo identify short-term changes in gene expression in peripheral blood mononuclear cells (PBMCs) associated with treatment response to dimethyl fumarate (DMF, Tecfidera) in patients with relapsing-remitting MS (RRMS).MethodsBlood samples were ...
Baranzini, Sergio E, Cencioni, Maria T, Gafson, Arie R, Kim, Kicheol, Matthews, Paul M, Nicholas, Richard, van Hecke, Wim   +6 more
core  

Semiconducting Polymer Nanoparticles Enable Light‐Controlled Bidirectional Modulation of Nitric Oxide in Endothelial Cells

Advanced Science, EarlyView.
Bimodal modulation of nitric oxide in endothelial cells is achieved by light‐sensitive polymer nanoparticles. In dark, P3HT/PEDOT:PSS NPs boost intracellular ·NO, upregulate both endothelial and induced nitric oxide synthase, and drive a metabolic shift toward glycolysis.
Camilla Marzuoli, Andrea Pianetti, Elena Mancinelli, Anthea Villano, Matteo Vailati, Paola Lagonegro, Miryam Criado‐Gonzalez, Montserrat Climent, Hansel Comas‐Rojas, Leonardo Elia, Francesco Moccia, Gabriele Tullii, Maria Rosa Antognazza   +12 more
wiley   +1 more source

Glucuronolactone Promotes Mucin Sulfation to Alleviate Deoxynivalenol‐Induced Intestinal Injury via Microbiota‐Dependent and ‐Independent AHR Activation

Advanced Science, EarlyView.
Glucuronolactone (GLU) as a natural metabolite of glucose, increases Lactobacillus amylovorus abundance and luminal IAA level to activate AHR signaling. In addition, GLU itself can directly elevate AHR signaling activity independently of microbiota and IAA.
Chenbin Cui, Beibei Zhang, Jiaxi Tang, Jing Hou, Yueqin Qiu, Kaiguo Gao, Li Wang, Zongyong Jiang, Xuefen Yang   +8 more
wiley   +1 more source

Carbamate compounds induced toxic effects by affecting Nrf2 signaling pathways

Toxicology Reports
Carbamate (CBs) is a class of insecticides which is being known as an important cause of intentional or accidental poisoning. CBs, cause carbamylation of acetylcholinesterase at neuronal synapses and neuromuscular junction. Exposure to CBs through skin contact, inhalation, or ingestion can result in significant cholinergic toxicity.
Mohammadbagher Nasrabadi, Maryam Nazarian, Majid Darroudi, Somayeh Marouzi, Mohammad Sadra Harifi-Mood, Saeed Samarghandian, Tahereh Farkhondeh   +6 more
openaire   +3 more sources

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

An insight into role of amino acids as antioxidants via NRF2 activation

Amino Acids
Oxidative stress can affect the protein, lipids, and DNA of the cells and thus, play a crucial role in several pathophysiological conditions. It has already been established that oxidative stress has a close association with inflammation via nuclear ...
Melford C. Egbujor, Olugbemi T. Olaniyan, Chigbundu N. Emeruwa, Sarmistha Saha, Luciano Saso, Paolo Tucci   +5 more
doaj   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source