Results 181 to 190 of about 15,068 (213)

Pseudovirus-mediated proximity labeling identifies candidate host cell membrane proteins involved in viral attachment. [PDF]

J Virol
Kotani N, Iwasa K, Amimoto T, Yamashita C, Komatsu K, Narimichi Y, Wakabayashi Y, Kurebayashi Y, Horiuchi Y, Kashimata L, Sasaki R, Kumagai M, Yagishita-Kyo N, Awaji T, Murakami T, Mizuno Y, Nakano M, Takahashi T, Takeuchi H, Honke K.   +19 more
europepmc   +1 more source

NRP1 and MMP9 are dual targets of RNA‐binding protein QKI5 to alter VEGF‐R/ NRP1 signalling in trophoblasts in preeclampsia [PDF]

Journal of Cellular and Molecular Medicine, 2021
AbstractPreeclampsia (PE) is characterized by placental ischemia and hypoxia, resulting in abnormal casting of the uterine spiral artery, which is mainly caused by insufficient trophoblastic cell infiltration. A reduction in levels of growth factor‐based signalling via Neuropilin‐1 (NRP1) has been shown to contribute to dysfunctional trophoblast ...
Weiwei Cheng, Weiwei Cheng
exaly   +3 more sources

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NRP1 cripples immunological memory

Nature Immunology, 2020
Durable responses to immunotherapy require the development of robust CD8+ T cell memory. A new study indicates that NRP1 differs from other checkpoint receptors as it functions as a checkpoint for the generation of memory.
Nandini Acharya, Ana C. Anderson
openaire   +2 more sources

Segregation Analysis of Rare NRP1 and NRP2 Variants in Families with Lymphedema [PDF]

Genes, 2020
Neuropilins are transmembrane coreceptors expressed by endothelial cells and neurons. NRP1 and NRP2 bind a variety of ligands, by which they trigger cell signaling, and are important in the development of lymphatic valves and lymphatic capillaries, respectively.
Sandro Michelini, Bruno Amato, Sercan Kenanoglu   +2 more
exaly   +5 more sources

STAT6 Upregulates NRP1 Expression in Endothelial Cells and Promotes Angiogenesis

Frontiers in Oncology, 2022
The role of signal transducer and activator of transcription 6 (STAT6) in tumor growth has been widely recognized. However, its effects on the regulation of angiogenesis remain unclear. In this study, we found that STAT6 promoted angiogenesis, possibly by increasing the expression of neuropilin-1 (NRP1) in endothelial cells (ECs). Both STAT6 inhibitor (
Peng Gao, Jiangjiu Liang, Ju Liu
exaly   +4 more sources

NRP1 is a receptor for mammalian orthoreovirus engaged by distinct capsid subunits

Cell Host and Microbe
Mammalian orthoreovirus (reovirus) is a nonenveloped virus that establishes primary infection in the intestine and disseminates to sites of secondary infection, including the CNS. Reovirus entry involves multiple engagement factors, but how the virus disseminates systemically and targets neurons remains unclear.
Terence S Dermody, David Alsteens, Danica M Sutherland   +2 more
exaly   +4 more sources

Surface Expression of NRP1 on Tregs Affects Outcome in Patients with Cancer

Cancer Discovery, 2022
Abstract High NRP1 surface expression can lead to more suppressive Tregs and reduces progression free survival.
openaire   +2 more sources