Results 101 to 110 of about 9,765 (234)

Dynamic protein interactions probed by NMR spectroscopy

Bulletin of the Korean Chemical Society, Volume 46, Issue 7, Page 680-690, July 2025.
Abstract Dynamic protein–protein interactions are essential for diverse cellular processes but often evade structural characterization due to their transient, heterogeneous, and disordered nature. This review focuses on how nuclear magnetic resonance (NMR) spectroscopy can provide detailed, residue‐level insights into these complex interactions.
Jaeseok Lee, Jung Ho Lee
wiley   +1 more source

Elbasvir/Grazoprevir: A Review of the Latest Agent in the Fight against Hepatitis C

International Journal of Hepatology, 2016
Hepatitis C virus (HCV) is estimated to affect up to 150 million people worldwide. Despite worldwide prevalence, treatment modalities prior to 2011 remained suboptimal, with low virologic response rates and intolerable side effect profiles.
Allison M. Bell, Jamie L. Wagner, Katie E. Barber, Kayla R. Stover   +3 more
doaj   +1 more source

Persistence of Virologic Response after Liver Transplant in Hepatitis C Patients Treated with Ledipasvir / Sofosbuvir Plus Ribavirin Pretransplant

Annals of Hepatology, 2017
Introduction: Recurrence of HCV infection in patients with chronic hepatitis C virus (HCV) at the time of liver transplantation is nearly universal and reduces the likelihood of graft and patient survival.
Eric M. Yoshida, Paul Kwo, Kosh Agarwal, Christophe Duvoux, François Durand, Markus Peck-Radosavljevic, Leslie Lilly, Bernard Willems, Hugo Vargas, Princy Kumar, Robert S. Brown Jr., Yves Horsmans, Shampa De-Oertel, Sarah Arterburn, Hadas Dvory-Sobol, Diana M. Brainard, John G. McHutchison, Norah Terrault, Mario Rizzetto, Beat Müllhaupt   +19 more
doaj   +1 more source

Overview of hepatitis C infection, molecular biology, and new treatment

Journal of Infection and Public Health, 2020
The World Health Organization estimates that 71 million people worldwide have chronic hepatitis C viral infection. A major challenge is overall lack of public awareness of hepatitis C, particularly among infected people of their infection status. Chronic
Ali A. Rabaan, Shamsah H. Al-Ahmed, Ali M. Bazzi, Wadha A. Alfouzan, Shahab A. Alsuliman, Fatimah A. Aldrazi, Shafiul Haque   +6 more
doaj   +1 more source

Hepatitis C Virus and Hepatocarcinogenesis [PDF]

, 2012
Hepatitis C virus (HCV) is an RNA virus that is unable to integrate into the host genome. However, its proteins interact with various host proteins and induce host responses.
Chung, Raymond Taeyong, Jang, Jae Young, Jeong, Soung Won   +2 more
core   +2 more sources

Growth Arrest and DNA Damage Protein 45A Promotes PPRV Replication via the Downregulation of TBK1 Expression to Inhibit IFN‐β Signaling Pathway

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
A working model of host protein GADD45A regulation of PPRV replication. During PPRV infection, the viral protein V forms a complex with GADD45A in the cytoplasm. GADD45A interacts with TBK1 and inhibits its expression. Similarly, V also interacts with TBK1 and inhibits TBK1 expression.
Haiyan Ding, Wenping Yang, Jinyan Wu, Junhuang Wu, Mengyi Wang, Jijun He, Ligang Yuan, Haixue Zheng, Youjun Shang, Dan Li   +9 more
wiley   +1 more source

Microbial translocation and T cell activation are modified by direct-acting antiviral therapy in HCV-infected patients [PDF]

, 2018
BACKGROUND: Microbial translocation from the gut lumen has been involved in the pathogenesis of liver damage in hepatitis C virus (HCV) infection. AIM: To investigate the impact of direct-acting antiviral treatment on microbial translocation and T ...
Baroncelli, Silvia, DE SANTIS, Adriano, GINANNI CORRADINI, Stefano, Lattanzi, Barbara, Lupo1, Marinella, Maria Galluzzo, Clementina, Mennini, Gianluca, Merli, Manuela, Michelini, Zuleika, Palmisano, Lucia, Rossi, Massimo   +10 more
core   +1 more source

Small molecule inhibitors of the hepatitis C virus-encoded NS5A protein

Virus Research, 2012
Hepatitis C virus (HCV) is a modern-day pandemic; 2-3% of the world's population are thought to be infected with the virus and are subsequently at risk of developing end-stage liver diseases. The traditional standard of care (SOC) for HCV-infected patients has been limited to a regimen of pegylated-interferon alpha (pegIFN) and ribavirin; displaying ...
Oscar, Belda, Paul, Targett-Adams
openaire   +2 more sources

NS3 of hepatitis C virus drives hepatocellular carcinoma progression through a novel RNA‐interference pathway

Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Abstract Hepatocellular carcinoma (HCC), a severe consequence of hepatitis C virus infection, is significantly influenced by the virus’s non‐structural protein 3 (NS3). This study employed transcriptome sequencing to explore the role of NS3 in promoting HCC progression by comparing gene expression profiles between HCV‐infected HCC tissues and healthy ...
Yajun Liang, Jian Luo, Liya Hu, Jun Zhang   +3 more
wiley   +1 more source

Profile of sofosbuvir/velpatasvir/voxilaprevir in the treatment of hepatitis C

Infection and Drug Resistance, 2019
Lindsey M Childs-Kean, Natalie A Brumwell, Emma F LodlDepartment of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL, USAAbstract: The treatment of chronic hepatitis C has been revolutionized with the
Childs-Kean LM, Brumwell NA, Lodl EF
doaj