Prevalence of NS5A resistance associated substitutions in patients with hepatitis C virus genotypes 1a and 3: Impact on current therapeutic strategies [PDF]
, 2018 [Abstract] The presence of resistance‐associated substitutions (RASs) at NS5A region might compromise the efficacy of Direct Acting Antiviral agents (DAAs).
Bagaglio +20 more
core +2 more sources
The mode and tempo of hepatitis C virus evolution within and among hosts [PDF]
, 2011 Background: Hepatitis C virus (HCV) is a rapidly-evolving RNA virus that establishes chronic infections in humans. Despite the virus' public health importance and a wealth of sequence data, basic aspects of HCV molecular evolution remain poorly ...
Aris Katzourakis +5 more
core +4 more sources
Recent advances in managing chronic HCV infection: Focus on therapy in patients with severe liver disease [PDF]
, 2016 Chronic hepatitis C virus (HCV) infection still represents a major public health problem, as it is thought to be responsible for more than 350,000 deaths around the globe on a yearly basis.
Maan, R. (Raoel) +1 more
core +5 more sources
Inhibition of hepatitis C virus infection by DNA aptamer against NS2 protein.
PLoS ONE, 2014 NS2 protein is essential for hepatitis C virus (HCV) replication. NS2 protein was expressed and purified. Aptamers against NS2 protein were raised and antiviral effects of the aptamers were examined.
Yimin Gao +9 more
doaj +1 more source
History and progress of antiviral drugs: from acyclovir to direct-acting antiviral agents (DAAs) for Hepatitis C [PDF]
, 2015 The development of antiviral drugs is a very complex process. Currently, around 50 drugs have been approved for human use against viruses such as HSV, HIV-1, the cytomegalo virus, the influenza virus, HBV and HCV.
Barrera Saldaña, Hugo Alberto +5 more
core
Cellular and Viral Determinants for Hepatitis C Virus Replication
, 2011 The recent discovery of an HCV isolate which replicates in cell culture has opened up opportunities to study the full viral life cycle in vitro. This genotype 2a isolate (JFH-1) and its derivatives are the only ones known to replicate efficiently in cell
Baillie, Andrew James +1 more
core +1 more source
Annals of HepatologyIntroduction and objectives: Chronic HCV infection induces the development of liver fibrosis mediated by hepatocyte epithelial-mesenchymal transition (EMT). Plasminogen activator inhibitor (PAI-1) has been associated with fibrosis. Objective: To evaluate
Tania G. Heredia-Torres +3 more
doaj +1 more source
Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a. [PDF]
Clin Infect Dis, 2020 Popping S +14 more
europepmc +1 more source
Eight weeks of sofosbuvir/velpatasvir for genotype 3 hepatitis C in previously untreated patients with significant (F2/3) fibrosis [PDF]
, 2020 Barclay, Stephen T. +7 more
core +3 more sources
Daclatasvir: potential role in hepatitis C [Corrigendum]
Drug Design, Development and Therapy, 2014 Lee C. Drug Des Devel Ther. 2013;7:1223–1233. On page 1231 in the "Conclusion" section, line 3 contains incorrect information. The correct sentence is "This review summarizes key preclinical and clinical data of an HCV NS5A inhibitor,
Lee C
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