Modulation of Autophagy-Like Processes by Tumor Viruses [PDF]
, 2014 Autophagy is an intracellular degradation pathway for long-lived proteins and organelles. This process is activated above basal levels upon cell intrinsic or environmental stress and dysregulation of autophagy has been linked to various human diseases ...
Mack, Hildegard I. D., Munger, Karl
core +1 more source
History and progress of antiviral drugs: from acyclovir to direct-acting antiviral agents (DAAs) for Hepatitis C [PDF]
, 2015 The development of antiviral drugs is a very complex process. Currently, around 50 drugs have been approved for human use against viruses such as HSV, HIV-1, the cytomegalo virus, the influenza virus, HBV and HCV.
Barrera Saldaña, Hugo Alberto +5 more
core
The mode and tempo of hepatitis C virus evolution within and among hosts [PDF]
, 2011 Background: Hepatitis C virus (HCV) is a rapidly-evolving RNA virus that establishes chronic infections in humans. Despite the virus' public health importance and a wealth of sequence data, basic aspects of HCV molecular evolution remain poorly ...
Aris Katzourakis +5 more
core +4 more sources
Type I interferon rapidly restricts infectious hepatitis C virus particle genesis [PDF]
, 2014 Interferon-alpha (IFNα) has been used to treat chronic hepatitis C virus (HCV) infection for over 20 years with varying efficacy, depending on the infecting viral genotype. The mechanism of action of IFNα is not fully understood, but is thought to target
Farquhar, Michelle J. +3 more
core +3 more sources
Current trends in the treatment of hepatitis C [PDF]
, 2016 Viral hepatitis, an inflammatory liver disease, is caused by various genotypes of hepatitis C viruses (HCV). Hepatitis C slowly sprouts into fibrosis, which progresses to cirrhosis.
Akhtar, Bushra +7 more
core +1 more source
Cellular and Viral Determinants for Hepatitis C Virus Replication
, 2011 The recent discovery of an HCV isolate which replicates in cell culture has opened up opportunities to study the full viral life cycle in vitro. This genotype 2a isolate (JFH-1) and its derivatives are the only ones known to replicate efficiently in cell
Baillie, Andrew James +1 more
core +1 more source
Inhibition of hepatitis C virus infection by DNA aptamer against NS2 protein.
PLoS ONE, 2014 NS2 protein is essential for hepatitis C virus (HCV) replication. NS2 protein was expressed and purified. Aptamers against NS2 protein were raised and antiviral effects of the aptamers were examined.
Yimin Gao +9 more
doaj +1 more source
Annals of HepatologyIntroduction and objectives: Chronic HCV infection induces the development of liver fibrosis mediated by hepatocyte epithelial-mesenchymal transition (EMT). Plasminogen activator inhibitor (PAI-1) has been associated with fibrosis. Objective: To evaluate
Tania G. Heredia-Torres +3 more
doaj +1 more source
Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a. [PDF]
Clin Infect Dis, 2020 Popping S +14 more
europepmc +1 more source
Eight weeks of sofosbuvir/velpatasvir for genotype 3 hepatitis C in previously untreated patients with significant (F2/3) fibrosis [PDF]
, 2020 Barclay, Stephen T. +7 more
core +3 more sources