Results 11 to 20 of about 9,765 (234)

Identification of novel neutralizing determinants for protection against HCV

Hepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein   +12 more
wiley   +1 more source

Synergistic Activity of Combined NS5A Inhibitors [PDF]

Antimicrobial Agents and Chemotherapy, 2016
ABSTRACT Daclatasvir (DCV) is a first-in-class hepatitis C virus (HCV) nonstructural 5A replication complex inhibitor (NS5A RCI) that is clinically effective in interferon-free combinations with direct-acting antivirals (DAAs) targeting alternate HCV proteins.
Donald R, O'Boyle, Peter T, Nower, Min, Gao, Robert, Fridell, Chunfu, Wang, Piyasena, Hewawasam, Omar, Lopez, Yong, Tu, Nicholas A, Meanwell, Makonen, Belema, Susan B, Roberts, Mark, Cockett, Jin-Hua, Sun   +12 more
openaire   +2 more sources

Identification of Hepatitis C Virus NS5A Inhibitors [PDF]

Journal of Virology, 2010
ABSTRACT Using a cell-based replicon screen, we identified a class of compounds with a thiazolidinone core structure as inhibitors of hepatitis C virus (HCV) replication. The concentration of one such compound, BMS-824, that resulted in a 50% inhibition of HCV replicon replication was ∼5 nM, with a therapeutic index of >10,000. The
Julie A, Lemm, Donald, O'Boyle, Mengping, Liu, Peter T, Nower, Richard, Colonno, Milind S, Deshpande, Lawrence B, Snyder, Scott W, Martin, Denis R, St Laurent, Michael H, Serrano-Wu, Jeffrey L, Romine, Nicholas A, Meanwell, Min, Gao   +12 more
openaire   +2 more sources

Inhibitors of NS5A for Treatment of HCV Infection [PDF]

ACS Medicinal Chemistry Letters, 2013
Inhibitors of NS5A for Treatment of HCV Infection Jean-Francois Brazeau and Gerard Rosse* Structure Guided Chemistry, Dart Neuroscience LLC, 7473 Lusk Boulevard, San Diego, California 92121, United States Adjunct Associate Professor, Department of Pharmacology and Physiology, College of Medicine, Drexel University, New College Building, 245 North 15th ...
Jean-Francois, Brazeau, Gerard, Rosse
openaire   +2 more sources

Synthesis and evaluation of non-dimeric HCV NS5A inhibitors [PDF]

Bioorganic & Medicinal Chemistry Letters, 2013
Based on the symmetrical bidentate structure of the NS5A inhibitor BMS-790052, a series of new monodentate molecules were designed. The synthesis of 36 new non-dimeric NS5A inhibitors is reported along with their ability to block HCV replication in an HCV 1b replicon system. Among them compound 5a showed picomolar range activity along with an excellent
Franck, Amblard, Hongwang, Zhang, Longhu, Zhou, Junxing, Shi, Drew R, Bobeck, James H, Nettles, Satish, Chavre, Tamara R, McBrayer, Philip, Tharnish, Tony, Whitaker, Steven J, Coats, Raymond F, Schinazi   +11 more
openaire   +2 more sources

Synthesis and evaluation of novel potent HCV NS5A inhibitors [PDF]

Bioorganic & Medicinal Chemistry Letters, 2012
Judicious modifications to the structure of the previously reported HCV NS5A inhibitor 1, resulted in more potent anti-HCV compounds with similar and in some cases improved toxicity profiles. The synthesis of 19 new NS5A inhibitors is reported along with their ability to block HCV replication in an HCV 1b replicon system.
Hongwang, Zhang, Longhu, Zhou, Franck, Amblard, Junxing, Shi, Drew R, Bobeck, Sijia, Tao, Tamara R, McBrayer, Phillip M, Tharnish, Tony, Whitaker, Steven J, Coats, Raymond F, Schinazi   +10 more
openaire   +2 more sources

Resistance Patterns Associated with HCV NS5A Inhibitors Provide Limited Insight into Drug Binding

Viruses, 2014
Direct-acting antivirals (DAAs) have significantly improved the treatment of infection with the hepatitis C virus. A promising class of novel antiviral agents targets the HCV NS5A protein.
Moheshwarnath Issur, Matthias Götte
doaj   +1 more source

Pre-existing minor variants with NS5A L31M/V-Y93H double substitution are closely linked to virologic failure with asunaprevir plus daclatasvir treatment for genotype 1b hepatitis C virus infection.

PLoS ONE, 2020
BackgroundL31 and Y93 in the NS5A region of the hepatitis C virus (HCV) are the most important substitution positions associated with resistance to direct-acting antiviral (DAA) treatment.MethodsWe analyzed the frequency of NS5A L31M/V and Y93/H in NS5A ...
Naoki Morishita, Ryotaro Sakamori, Tomomi Yamada, Yugo Kai, Yuki Tahata, Ayako Urabe, Ryoko Yamada, Takahiro Kodama, Hayato Hikita, Yoshinori Doi, Shinji Tamura, Hideki Hagiwara, Yasuharu Imai, Sadaharu Iio, Tomohide Tatsumi, Tetsuo Takehara   +15 more
doaj   +1 more source

Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes [PDF]

ACS Medicinal Chemistry Letters, 2011
The iminothiazolidinone BMS-858 (2) was identified as a specific inhibitor of HCV replication in a genotype 1b replicon assay via a high-throughput screening campaign. A more potent analogue, BMS-824 (18), was used in resistance mapping studies, which revealed that inhibitory activity was related to disrupting the function of the HCV nonstructural ...
Jeffrey L, Romine, Denis R, St Laurent, John E, Leet, Scott W, Martin, Michael H, Serrano-Wu, Fukang, Yang, Min, Gao, Donald R, O'Boyle, Julie A, Lemm, Jin-Hua, Sun, Peter T, Nower, Xiaohua Stella, Huang, Milind S, Deshpande, Nicholas A, Meanwell, Lawrence B, Snyder   +14 more
openaire   +2 more sources

Molecular Epidemiology and Baseline Resistance of Hepatitis C Virus to Direct Acting Antivirals in Croatia

Pathogens, 2022
Molecular epidemiology of hepatitis C virus (HCV) is exceptionally complex due to the highly diverse HCV genome. Genetic diversity, transmission dynamics, and epidemic history of the most common HCV genotypes were inferred by population sequencing of the
Petra Simicic, Anamarija Slovic, Leona Radmanic, Adriana Vince, Snjezana Zidovec Lepej   +4 more
doaj   +1 more source