Results 131 to 140 of about 38,142 (142)

In Silico and In Vitro development of novel small interfering RNAs (siRNAs) to inhibit SARS-CoV-2. [PDF]

Comput Struct Biotechnol J
Taibe NS, Mahmoud SH, Kord MA, Badawy MA, Shehata M, Elhefnawi M.   +5 more
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Discovery of thiacyanine dyes as a new class of potent coronavirus inhibitors that suppress viral RNA synthesis. [PDF]

J Biol Chem
Zhang T, Altouma V, Sommers JA, Dumm AJ, Kennedy D, Xia H, Yang M, Fullenkamp CR, Huang SN, Xue Y, Su S, Shen W, Haren CE, Kulikowicz T, Pommier Y, Schneekloth JS, Garcia-Blanco MA, Brosh RM, Wang W.   +18 more
europepmc   +1 more source

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Typing of alpha and beta coronaviruses by DNA barcoding of NSP12 gene

Journal of Medical Virology, 2022
AbstractSince the spread of the COVID‐19 pandemic, the world paid attention to coronaviruses (CoVs) evolution and their diverged lineages because many researches studies supposed that the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is evolutionarily developed from a lineage of bats CoVs.
Waleed A. Nemr, Nashwa K. Radwan
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Development and characterization of a new monoclonal antibody against SARS‐CoV‐2 NSP12 (RdRp)

Journal of Medical Virology, 2022
AbstractSARS‐CoV‐2 NSP12, the viral RNA‐dependent RNA polymerase (RdRp), is required for viral replication and is a therapeutic target to treat COVID‐19. To facilitate research on SARS‐CoV‐2 NSP12 protein, we developed a rat monoclonal antibody (CM12.1) against the NSP12 N‐terminus that can facilitate functional studies.
Wen Meng, Siying Guo, Simon Cao, Masahiro Shuda, Lindsey R. Robinson‐McCarthy, Kevin R. McCarthy, Yoko Shuda, Alberto E. Paniz Mondolfi, Clare Bryce, Zachary Grimes, Emilia M. Sordillo, Carlos Cordon‐Cardo, Pengfei Li, Hu Zhang, Stanley Perlman, Haitao Guo, Shou‐Jiang Gao, Yuan Chang, Patrick S. Moore   +18 more
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In-Silico Analysis to Identify Potential Inhibitors Against the Protein NSP12 of SARS-CoV-2

International Journal of Quantitative Structure-Property Relationships, 2021
In this pandemic condition, a drug candidate which is effective against COVID-19 is very much desired. This study initiates an in silico analysis to screen small molecules such as phytochemicals, drug metabolites, and natural metabolites against Nsp12 (a catalytic unit for RNA transcription and replication).
Hima Vyshnavi, null Gayathri S. S., Shahanas Naisam, Suvanish Kumar, Nidhin Sreekumar   +4 more
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Erratum: The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent

2011
The authors wish to apologise for an error in the concentration of tetracycline used to induce SARS-coronavirus nsp12 expression in E. coli. In the second paragraph of Materials and Methods, the sentence: “Subsequently, the cells were slowly cooled to room temperature, tetracycline was added to a final concentration of 200 μg/ml and the cells were ...
Snijder, Eric J., Arnold, Jamie J., van den Worm, Sjoerd H. E. , te Velthuis, Aartjan J. W., Cameron, Craig E.   +4 more
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SARS‐CoV‐2 NSP12 utilizes various host splicing factors for replication and splicing regulation

Journal of Medical Virology
Abstract The RNA‐dependent RNA polymerase (RdRp) is a crucial element in the replication and transcription of RNA viruses. Although the RdRps of lethal human coronaviruses severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), SARS‐CoV, and Middle East respiratory syndrome coronavirus (MERS‐CoV) have been extensively studied ...
Li Yang, Xiao‐Tao Zeng, Rong‐Hua Luo, Si‐Xue Ren, Lin‐Lin Liang, Qiu‐Xia Huang, Ying Tang, Hong Fan, Hai‐Yan Ren, Wan‐Jiang Zhang, Yong‐Tang Zheng, Wei Cheng   +11 more
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Drug repositioning to identify SARS-CoV-2 Nsp12/Nsp8 interaction interface inhibitors.

2020
Uğurel, Erennur, KOÇER, SİNEM, BALIK, DİLEK, ATA, OĞUZ, SARIYER, EMRAH, UĞUREL, OSMAN MUTLUHAN, MUTLU, ÖZAL, İnci, Tuğba Gül   +7 more
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Repurposed drug molecule targeting NSP12 protein of SARS-CoV-2: A bioinformatics study

Bhawna Sharma, Angel, Bennet, Joshi, Vinod, Angel, Annette, B M Shareef, Singh, Neha, Poorna Khaneja, Nuzhat Peer, Shafaat Ambreen, Khan, Shilpa, Barthwal   +10 more
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