Results 101 to 110 of about 14,750 (231)

The Coronavirus Nucleocapsid is a Multifunctional Protein [PDF]

, 2014
The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly ...
Fielding, Burtram C., McBride, Ruth, van Zyl, Marjorie   +2 more
core   +2 more sources

Engineered RNA Devices for In Vivo Targeted Therapeutics via Advanced Delivery Systems

Aggregate, Volume 6, Issue 11, November 2025.
Schematic illustration of engineered RNA devices for in vivo targeted therapeutics via advanced delivery systems. ABSTRACT Engineered RNA devices can identify disease‐specific markers and precisely regulate gene expression, which is of great significance to the development of precision medicine.
Wei Luo, Xia Liu, Ying Han, Yijing Duan, Chuao Yu, Na Kong, Tian Xie   +6 more
wiley   +1 more source

Understanding the evolution and spread of chikungunya virus in the Americas using complete genome sequences

, 2017
Local transmission of chikungunya virus (CHIKV) was first detected in the Americas in December 2013, after which it spread rapidly throughout the Caribbean islands and American mainland, causing a major ...
Allicock, O. M., Auguste, A. J., Carrington, C. V. F., Gutierrez, C., Martínez de Salazar, Pablo, Olowokure, B., Polson-Edwards, K., Sahadeo, N. S. D., Valadere, A. M., Weaver, S. C., Widen, S.   +10 more
core   +1 more source

Nanomaterial‐Based Precision Medicine for Breast Cancer Diagnosis and Treatment

ChemNanoMat, Volume 11, Issue 11, November 2025.
This research emphasizes the use of targeted precision medicine in the treatment of breast cancer. Through the integration of diagnosis and therapeutic delivery, nanocarriers are designed to selectively target cancer cells, preserving healthy tissue, thereby improving treatment effectiveness and reducing side effects.
Tanaka Ndongwe, Xavier Siwe Noundou, Gauta Gold Matlou, Stéphanie Bessoles, Johanne Seguin, Cyrille Richard, Nathalie Mignet, Yohann Corvis, Bwalya Angel Witika   +8 more
wiley   +1 more source

Discovery of in silico hits targeting the nsP3 macro domain of chikungunya virus [PDF]

Journal of Molecular Modeling, 2014
The recent emergence and re-emergence of alphaviruses, in particular the chikungunya virus (CHIKV), in numerous countries has invoked a worldwide threat to human health, while simultaneously generating an economic burden on affected countries. There are currently no vaccines or effective drugs available for the treatment of the CHIKV, and with few lead
Nguyen, Phuong, Yu, Haibo, Keller, Paul
openaire   +3 more sources

Expression, purification and characterization of fungal and viral recombinant proteins [PDF]

, 2001
This work reports the production of recombinant yeast and viral proteins in a number of diverse in vivo model systems for enzymatic and structural studies.
Vihinen, Helena
core  

Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

Antiviral Research, 2018
The multi-domain non-structural protein 3 (Nsp3) is the largest protein encoded by the coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an essential component of the replication/transcription complex. It comprises various domains, the organization of which differs between CoV genera, due to duplication or absence of ...
Lei, Jian, Kusov, Yuri, Hilgenfeld, Rolf
openaire   +2 more sources

The European Union summary report on surveillance for the presence of transmissible spongiform encephalopathies (TSE) in 2024

EFSA Journal, Volume 23, Issue 11, November 2025.
ABSTRACT This report presents results of surveillance on transmissible spongiform encephalopathies in bovines, sheep, goats, cervids and other species, and genotyping in sheep and goats, carried out in 2024 by 27 EU Member States (EU27, MS), the UK (in respect of Northern Ireland, (XI)) and 8 non‐EU reporting countries: Bosnia and Herzegovina, Iceland,
European Food Safety Authority (EFSA), Romolo Nonno, Giuseppe Ru, Roxani Aminalragia‐Giamini, Catalin Iancu, Angel Ortiz‐Pelaez, Kamela Kryemadhi, Francesca Baldinelli   +7 more
wiley   +1 more source

NMR screening of low molecular weight inhibitors targeting the papain‐like protease (PLPro) of SARS‐CoV‐2

FEBS Open Bio, Volume 15, Issue 10, Page 1667-1677, October 2025.
Papain‐like protease from SARS‐CoV‐2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR screening study. We identified 86 binding compounds, of which five candidates were chosen for in‐depth analysis.
Dennis J. Pyper, Sridhar Sreeramulu, Benjamin T. Lanham, Elizabeth M. Engle, David Fushman, Harald Schwalbe   +5 more
wiley   +1 more source

Evaluation of a range of mammalian and mosquito cell lines for use in Chikungunya virus research [PDF]

, 2017
Chikungunya virus (CHIKV) is becoming an increasing global health issue which has spread across the globe and as far north as southern Europe. There is currently no vaccine or anti-viral treatment available.
A Lo Presti, B Salvador, BK Dove, BM Gunn, C Caglioti, C Paupy, C Porter, C Rhein von, CB Willberg, CW Chiam, D Olagnier, D Ross-Thriepland, DE Brackney, EM Morazzani, F Deeba, F Parker, G Zhang, GM Liumbruno, GV Gee, JC Scott, KM Gallegos, L Colibus De, L Josseran, L Pohjala, LC Ng, LR Feldstein, M Mavale, M Pudney, M Sourisseau, M Varjak, MA Lawson, MU Kraemer, O Schwartz, OJ Brady, P Gérardin, R Broeckel, R Remenyi, RS Lanciotti, RWC Siu, S Burattini, S Choi, S Hover, S Mattar, SC Weaver, SC Weaver, SC Weaver, SM Rampal, SP Reid, T Macleod, Ö Cesur   +49 more
core   +2 more sources