Interactions of Alphavirus nsP3 Protein with Host Proteins [PDF]
Frontiers in Microbiology, 2018 Alphaviruses are members of the Togaviridae family and are grouped into two categories: arthritogenic and encephalitic. Arthritogenic alphavirus infections, as the name implies, are associated with arthritic outcomes while encephalitic alphavirus ...
Tyler Lark +2 more
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Involvement of PRRSV NSP3 and NSP5 in the autophagy process
Virology Journal, 2019 Background Autophagy is an essential process in eukaryotic cells in which autophagosomes form to deliver cellular organelles and long-lived proteins to lysosomes for degradation. Many studies have recently identified the regulatory mechanisms involved in
Wei Zhang +4 more
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Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors
Pathogens, 2023 The worldwide public health and socioeconomic consequences caused by the COVID-19 pandemic highlight the importance of increasing preparedness for viral disease outbreaks by providing rapid disease prevention and treatment strategies.
Marion Schuller +8 more
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Nature CommunicationsAlphaviruses, such as chikungunya virus (CHIKV), are mosquito-borne viruses that represent a significant threat to human health due to the current context of global warming.
Vasiliya Kril +16 more
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DNAJ Homolog Subfamily C Member 11 Stabilizes SARS-CoV-2 NSP3 to Promote Double-Membrane Vesicle Formation [PDF]
VirusesChen S +10 more
europepmc +3 more sources
Functional Analysis of nsP3 Phosphoprotein Mutants ofSindbisVirus [PDF]
Journal of Virology, 2003 ABSTRACT Alphavirus nsP3 phosphoprotein is essential for virus replication and functions initially within polyprotein P123 or P23 components of the short-lived minus-strand replicase, and upon polyprotein cleavage, mature nsP3 likely functions also in plus-strand synthesis.
Indra Dè +3 more
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Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV2 nsp3 Macrodomain [PDF]
Bioorganic & Medicinal Chemistry, 2022 AbstractA series of amino acid based7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to discern the structure activity relationships against the SARS-CoV-2 nsp3 macrodomain (Mac1), an ADP-ribosylhydrolase that is critical for coronavirus replication and pathogenesis.
Lavinia M. Sherrill +14 more
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YBX1 is required for assembly of viral replication complexes of chikungunya virus and replication of multiple alphaviruses [PDF]
Journal of VirologyChikungunya virus (CHIKV), an enveloped positive-sense RNA virus, is a member of the alphaviruses and cause fever and arthralgia in humans. We performed genome-wide CRISPR/Cas9-based screens and identified Y-box binding protein 1 (YBX1) as an essential ...
Zhen-Qi Li +5 more
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READDI protocol: Crystallisation of CHIKV nsP3 macrodomain v1 [PDF]
Chikungunya virus (CHIKV) causes severe fever, rash and debilitating joint pain that can last for months or even years. Millions of people have been infected with CHIKV, mostly in low- and middle-income countries, and the virus continues to spread into new areas due to the geographical expansion of its mosquito hosts.
J.C. Aschenbrenner +2 more
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Proximity interactome of alphavirus replicase component nsP3 includes proviral host factors eIF4G and AHNAK. [PDF]
PLoS PathogensAll positive-strand RNA viruses replicate their genomes in association with modified intracellular membranes, inducing either membrane invaginations termed spherules, or double-membrane vesicles. Alphaviruses encode four non-structural proteins nsP1-nsP4,
Aditya Thiruvaiyaru +6 more
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