Results 21 to 30 of about 14,750 (231)

Structure‐Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus‐2 Nsp3 Macrodomain [PDF]

ChemBioChem, Volume 26, Issue 23, November 27, 2025.
Structure‐guided design of a sulfamoyl‐modified analog of GS‐441524 yielded a selective, high‐affinity inhibitor of the SARS‐CoV‐2 macrodomain Nsp3b. The compound occupies the phosphate‐binding pocket, forming a stabilizing hydrogen‐bond network that enhances binding affinity (K_D = 0.86 μM).
Robin Krishnathas, Константин С. Минеев, Nikolaos K. Fourkiotis, Franck Touret, Christos Sideras‐Bisdekis, Aikaterini C. Tsika, S.L. Gande, V.L. Linhard, Sridhar Sreeramulu, F. Lennartz, M.S. Weiss, Bruno Coutard, Georgios A. Spyroulias, Harald Schwalbe   +13 more
openalex   +2 more sources

Identification of compounds targeting porcine reproductive and respiratory syndrome virus nsp3 and evaluation of their antiviral efficacy. [PDF]

Virulence
He Z, Nie Z, Liao J, Liu M, Li F, Chen B, Guo C.   +6 more
europepmc   +2 more sources

A conserved motif within the NSP2 of SARS-CoV-2 is required for processing of the distal NSP1/NSP2 junction by NSP3. [PDF]

Sci Rep
Kristensen T, Normann P, Belsham GJ.
europepmc   +3 more sources

Proximity interactome of alphavirus replicase component nsP3 includes proviral host factors eIF4G and AHNAK. [PDF]

PLoS Pathogens
All positive-strand RNA viruses replicate their genomes in association with modified intracellular membranes, inducing either membrane invaginations termed spherules, or double-membrane vesicles. Alphaviruses encode four non-structural proteins nsP1-nsP4,
Aditya Thiruvaiyaru, Sari Mattila, Mohammadreza Sadeghi, Krystyna Naumenko, Andres Merits, Markku Varjosalo, Tero Ahola   +6 more
doaj   +2 more sources

The nsp3 Macrodomain Promotes Virulence in Mice with Coronavirus-Induced Encephalitis [PDF]

Journal of Virology, 2014
ABSTRACT All coronaviruses encode a macrodomain containing ADP-ribose-1″-phosphatase (ADRP) activity within the N terminus of nonstructural protein 3 (nsp3). Previous work showed that mouse hepatitis virus strain A59 (MHV-A59) with a mutated catalytic site (N1348A) replicated similarly to wild-type virus but was unable to cause ...
Anthony R. Fehr, Jeremiah Athmer, Rudragouda Channappanavar, Judith M. Phillips, David K. Meyerholz, Stanley Perlman   +5 more
openalex   +3 more sources

Transient SARS-CoV-2 RNA-Dependent RNA Polymerase Mutations after Remdesivir Treatment for Chronic COVID-19 in Two Transplant Recipients: Case Report and Intra-Host Viral Genomic Investigation

Microorganisms, 2023
Remdesivir is the first FDA-approved drug for treating severe SARS-CoV-2 infection and targets RNA-dependent RNA polymerase (RdRp) that is required for viral replication.
Shangxin Yang, Ashrit Multani, Jacob M. Garrigues, Michael S. Oh, Peera Hemarajata, Taylor Burleson, Nicole M. Green, Caspian Oliai, Pryce T. Gaynor, Omer E. Beaird, Drew J. Winston, Christopher S. Seet, Joanna M. Schaenman   +12 more
doaj   +1 more source

Preparation of polyclonal antibodies and subcellular localization of non-structural protein 3 encoded by feline coronavirus

浙江大学学报. 农业与生命科学版, 2023
The non-structural protein 3 (Nsp3) of coronavirus, a component of the replication and transcription complex, is one of the potentially important antiviral targets.
WANG Ziyi, JIN Zi’an, LU Chenhe, QIAO Zhi, WANG Shengwen, YAN Yan, ZHOU Jiyong, ZHENG Xiaojuan   +7 more
doaj   +1 more source

Species A rotavirus NSP3 acquires its translation inhibitory function prior to stable dimer formation. [PDF]

PLoS ONE, 2017
Species A rotavirus non-structural protein 3 (NSP3) is a translational regulator that inhibits or, under some conditions, enhances host cell translation.
Hugo I Contreras-Treviño, Edgar Reyna-Rosas, Renato León-Rodríguez, Blanca H Ruiz-Ordaz, Tzvetanka D Dinkova, Ana M Cevallos, Luis Padilla-Noriega   +6 more
doaj   +1 more source

Identification of NSP3 (SH2D3C) as a Prognostic Biomarker of Tumor Progression and Immune Evasion for Lung Cancer and Evaluation of Organosulfur Compounds from Allium sativum L. as Therapeutic Candidates

Biomedicines, 2021
The multi-domain non-structural protein 3 (NSP3) is an oncogenic molecule that has been concomitantly implicated in the progression of coronavirus infection. However, its oncological role in lung cancer and whether it plays a role in modulating the tumor
Yuan-Chieh Yeh, Bashir Lawal, Michael Hsiao, Tse-Hung Huang, Chi-Ying F. Huang   +4 more
doaj   +1 more source

Functional Analysis of nsP3 Phosphoprotein Mutants ofSindbisVirus [PDF]

Journal of Virology, 2003
ABSTRACT Alphavirus nsP3 phosphoprotein is essential for virus replication and functions initially within polyprotein P123 or P23 components of the short-lived minus-strand replicase, and upon polyprotein cleavage, mature nsP3 likely functions also in plus-strand synthesis.
Indra, Dé, Cori, Fata-Hartley, Stanley G, Sawicki, Dorothea L, Sawicki   +3 more
openaire   +2 more sources