Results 41 to 50 of about 14,750 (231)

Prediction of Anti-SARS CoV-2 Activity from Green Tea Catechin (Camellia sinensis L. Kuntze) Compound Against To Receptors Non-structural Protein 3 (6W6Y) And Non-structural Protein 5 (6M2N)

Majalah Obat Tradisional, 2022
Green tea catechin compounds (Camellia sinensis L. Kuntze) have an antiviral activity such as influenza, hepatitis B, hepatitis C, herpes simplex virus, HIV, and proven in vitro antiviral influenza against NSP5 in SARS CoV.
Roihatul Mutiah, Chamlah Ayatillah, Yen yen Ari Indrawijaya, Arief Suryadinata   +3 more
doaj   +1 more source

Scalable Inhibitors of the Nsp3–Nsp4 Coupling in SARS-CoV-2

ACS Omega, 2023
The human Betacoronavirus SARS-CoV-2 is a novel pathogen claiming millions of lives and causing a global pandemic that has disrupted international healthcare systems, economies, and communities. The virus is fast mutating and presenting more infectious but less lethal versions. Currently, some small-molecule therapeutics have received FDA emergency use
Abdul-Rahman Azizogli, Varun Pai, Francesco Coppola, Roya Jafari, Joseph B. Dodd-o, Rohan Harish, Bhavani Balasubramanian, Jatin Kashyap, Amanda M. Acevedo-Jake, Petr Král, Vivek A. Kumar   +10 more
openaire   +2 more sources

Crystal structure of the CoV-Y domain of SARS-CoV-2 nonstructural protein 3

Scientific Reports, 2023
Replication of the coronavirus genome starts with the formation of viral RNA-containing double-membrane vesicles (DMV) following viral entry into the host cell.
Yunfeng Li, Yulia Pustovalova, Wuxian Shi, Oksana Gorbatyuk, Sridhar Sreeramulu, Harald Schwalbe, Jeffrey C. Hoch, Bing Hao   +7 more
doaj   +1 more source

Predicted binding interface between coronavirus nsp3 and nsp4 [PDF]

, 2022
AbstractDouble membrane vesicles (DMVs) in coronavirus-infected cells feature pores that span both membranes. DMV pores were observed to have six-fold symmetry and include the nsp3 protein. Co-expression of SARS-CoV nsp3 and nsp4 induces DMV formation, and elements of nsp3 and nsp4 have been identified that are essential for membrane disruption.
openaire   +1 more source

ZAP's stress granule localization is correlated with its antiviral activity and induced by virus replication. [PDF]

, 2019
Cellular antiviral programs encode molecules capable of targeting multiple steps in the virus lifecycle. Zinc-finger antiviral protein (ZAP) is a central and general regulator of antiviral activity that targets pathogen mRNA stability and translation ...
Jurado, Andrea, Law, Lok Man John, Li, Melody MH, MacDonald, Margaret R, Razooky, Brandon S, Rice, Charles M, You, Shihyun   +6 more
core   +2 more sources

In-silico prediction of novel drug-target complex of nsp3 of CHIKV through molecular dynamic simulation

Heliyon, 2020
Literature reported that nsp3 of CHIKV is an important target for the designing of drug as it involves in the replication, survival etc. Herein, about eighteen million molecules available in the ZINC database are filtered against nsp3 using RASPD.
Durgesh Kumar, Mahendra Kumar Meena, Kamlesh Kumari, Rajan Patel, Abhilash Jayaraj, Prashant Singh   +5 more
doaj   +1 more source

A Tale of 20 Alphaviruses; Inter-species Diversity and Conserved Interactions Between Viral Non-structural Protein 3 and Stress Granule Proteins

Frontiers in Cell and Developmental Biology, 2021
Alphaviruses infect a diverse range of host organisms including mosquitoes, mammals, and birds. The enigmatic alphavirus non-structural protein 3 (nsP3) has an intrinsically disordered, C-terminal hypervariable domain (HVD) that can interact with a ...
Gwen Nowee, Julian W. Bakker, Corinne Geertsema, Vera I. D. Ros, Giel P. Göertz, Jelke J. Fros, Gorben P. Pijlman   +6 more
doaj   +1 more source

Structural insights into SARS-CoV-2 nonstructural protein 4 (nsp4) biogenesis. [PDF]

Protein Sci
Abstract The SARS‐CoV‐2 virus—responsible for the COVID‐19 pandemic—requires a replication–transcription complex (RTC) for efficient RNA synthesis and viral propagation. One critical RTC component is nonstructural protein 4 (nsp4), a multipass transmembrane (TM) protein implicated in endoplasmic reticulum (ER) membrane rearrangements and double ...
Acosta-Cáceres JM, Lolicato F, Gadea-Salom L, Ortiz-Mateu J, Belda D, Martínez-Gil L, García-Murria MJ, Mingarro I.   +7 more
europepmc   +2 more sources

Implementation of a Multiplex PCR Amplification System Combined With Next-Generation Genome Sequencing to Decipher the Circulation of Human Coronavirus 229E Lineages in Southern France. [PDF]

J Med Virol
ABSTRACT Coronaviruses rapidly evolve and are prone to new virus emergence. Human coronavirus (HCoV)−229E is one of the seven coronaviruses (aside HCoV‐OC43, HCoV‐HKU1, HCoV‐NL63, SARS‐CoV, MERS‐CoV, SARS‐CoV‐2) causing respiratory infections in humans. Genomic data are very scarce for this virus.
Hikmat H, Py J, Boschi C, Burel E, Le Targa L, Million M, Lesage L, Morand A, La Scola B, Colson P.   +9 more
europepmc   +2 more sources

Rotavirus Protein NSP3 Shuts Off Host Cell Protein Synthesis

Virology, 2002
A recombinant vaccinia virus encoding rotavirus protein NSP3 driven by an internal ribosome entry site (IRES) from the encephalomyocarditis (EMC) virus was able to abate protein synthesis in BSC1 cells by 25-fold, with as much as 30% of the remaining protein synthesis being NSP3.
Padilla-Noriega, Luis, Paniagua, Octavio, Guzmán-León, Simón   +2 more
openaire   +2 more sources