Results 51 to 60 of about 14,750 (231)

COVID‐2019: The role of the nsp2 and nsp3 in its pathogenesis [PDF]

Journal of Medical Virology, 2020
AbstractLast December 2019, a new virus, named novel Coronavirus (COVID‐2019) causing many cases of severe pneumonia was reported in Wuhan, China. The virus knowledge is limited and especially about COVID‐2019 pathogenesis. The Open Reading Frame 1ab (ORF1ab) of COVID‐2019 has been analyzed to evidence the presence of mutation caused by selective ...
Silvia Angeletti, Domenico Benvenuto, Martina Bianchi, Marta Giovanetti, Stefano Pascarella, Massimo Ciccozzi   +5 more
openaire   +3 more sources

Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication [PDF]

Open Biology, 2016
Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon environmental ...
Tim Schulte, Lifeng Liu, Marc D. Panas, Bastian Thaa, Nicole Dickson, Benjamin Götte, Adnane Achour, Gerald M. McInerney   +7 more
doaj   +1 more source

Preparation and Evaluation of Diosmin-Loaded Diphenylcarbonate-Cross-Linked Cyclodextrin Nanosponges for Breast Cancer Therapy

Pharmaceuticals, 2022
In the current study, diosmin (DSM)-loaded beta-cyclodextrin (β-CD)-based nanosponges (NSPs) using diphenylcarbonate (DPC) as a cross-linker were prepared.
Md. Khalid Anwer, Mohammed Muqtader Ahmed, Mohammed F. Aldawsari, Muzaffar Iqbal, Vinay Kumar   +4 more
doaj   +1 more source

Rotavirus Nonstructural Protein NSP3 Is Not Required for Viral Protein Synthesis [PDF]

Journal of Virology, 2006
ABSTRACT Initiation is the rate-limiting step in protein synthesis and therefore an important target for regulation. For the initiation of translation of most cellular mRNAs, the cap structure at the 5′ end is bound by the translation factor eukaryotic initiation factor 4E (eIF4E), while the poly(A) tail, at the 3′ end, is recognized by the ...
Hilda Montero, Carlos F. Arias, Susana López   +2 more
openalex   +3 more sources

Identification of mosquito proteins that differentially interact with alphavirus nonstructural protein 3, a determinant of vector specificity.

PLoS Neglected Tropical Diseases, 2023
Chikungunya virus (CHIKV) and the closely related onyong-nyong virus (ONNV) are arthritogenic arboviruses that have caused significant, often debilitating, disease in millions of people.
Nathaniel M Byers, Paul L Burns, Olga Stuchlik, Matthew S Reed, Jeremy P Ledermann, Jan Pohl, Ann M Powers   +6 more
doaj   +1 more source

Structure of the X (ADRP) domain of nsp3 from feline coronavirus [PDF]

Acta Crystallographica Section D Biological Crystallography, 2009
The structure of the X (or ADRP) domain of a pathogenic variant of feline coronavirus (FCoV) has been determined in tetragonal and cubic crystal forms to 3.1 and 2.2 A resolution, respectively. In the tetragonal crystal form, glycerol-3-phosphate was observed in the ADP-ribose-binding site.
Wojdyla, J. A., Manolaridis, I., Snijder, E. J., Gorbalenya, A. E., Coutard, B., Piotrowski, Y., Hilgenfeld, R., Tucker, P. A.   +7 more
openaire   +3 more sources

Mosquito Rasputin interacts with chikungunya virus nsP3 and determines the infection rate in Aedes albopictus

Parasites & Vectors, 2015
Background Chikungunya virus (CHIKV) is an arthritogenic alphavirus (family Togaviridae), transmitted by Aedes species mosquitoes. CHIKV re-emerged in 2004 with multiple outbreaks worldwide and recently reached the Americas where it has infected over a ...
Jelke J. Fros, Corinne Geertsema, Karima Zouache, Jim Baggen, Natalia Domeradzka, Daniël M. van Leeuwen, Jacky Flipse, Just M. Vlak, Anna-Bella Failloux, Gorben P. Pijlman   +9 more
doaj   +1 more source

WHOLE GENOME SEQUENCE OF SARS-COV-2 FROM COVID-19 ACQUIRED HEMOPHILIA PATIENT

International Journal of Infectious Diseases, 2023
Intro: Acquired hemophilia is an atypical pathology of SARS-CoV-2 infection, which could be variant associated. Here, we share a sequence of the SARS-CoV-2 genome from patient with COVID-19 acquired haemophilia.
U.A. Zainulabid, A. Aslam, M. Hussain, I. Ibrahim, P. Periyasamy, N. Kamarudin, H.F. Ahmad   +6 more
doaj   +1 more source

Knockdown of piRNA pathway proteins results in enhanced Semliki forest virus production in mosquito cells [PDF]

, 2013
The exogenous siRNA pathway is important in restricting arbovirus infection in mosquitoes. Less is known about the role of the PIWI-interacting RNA pathway, or piRNA pathway, in antiviral responses. Viral piRNA-like molecules have recently been described
Donald, Claire L., Fazakerley, John K., Fragkoudis, Rennos, Human, Stacey, Kohl, Alain, McFarlane, Melanie, Schnettler, Esther, Siu, Ricky W. C., Watson, Mick   +8 more
core   +3 more sources

Alphavirus nsP3 functions to form replication complexes transcribing negative-strand RNA [PDF]

Journal of Virology, 1994
The alphavirus mutant Sindbis virus HR ts4, which has been assigned to the A complementation group, possessed a selective defect in negative-strand synthesis that was similar although not identical to that observed for the B complementation group mutant ts11 (Y.-F. Wang, S. G. Sawicki, and D. L. Sawicki, J. Virol. 65:985-988, 1991). The causal mutation
Y F, Wang, S G, Sawicki, D L, Sawicki
openaire   +2 more sources