Results 61 to 70 of about 9,413 (173)
High-resolution functional mapping of the venezuelan equine encephalitis virus genome by insertional mutagenesis and massively parallel sequencing. [PDF]
PLoS Pathogens, 2010 We have developed a high-resolution genomic mapping technique that combines transposon-mediated insertional mutagenesis with either capillary electrophoresis or massively parallel sequencing to identify functionally important regions of the Venezuelan ...
Brett F Beitzel +3 more
doaj +1 more source
Scientific Reports, 2017 Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes febrile disease, muscle and joint pain, which can become chronic in some individuals. The non-structural protein 3 (nsP3) plays essential roles during infection, but a complete understanding ...
Roland Remenyi +4 more
doaj +1 more source
Insighting isatin derivatives as potential antiviral agents against NSP3 of COVID-19
Chemical Papers, 2022 The world is now facing intolerable damage in all sectors of life because of the deadly COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2. The discovery and development of anti-SARS-CoV-2 drugs have become pragmatic in the time needed to fight against this pandemic.
Mubashar Ilyas +8 more
openaire +3 more sources
mBio, 2017 Betacoronaviruses, such as Middle East respiratory syndrome coronavirus (MERS-CoV), are important pathogens causing potentially lethal infections in humans and animals.
Diede Oudshoorn +7 more
doaj +1 more source
Rotavirus Protein NSP3 Shuts Off Host Cell Protein Synthesis
Virology, 2002 A recombinant vaccinia virus encoding rotavirus protein NSP3 driven by an internal ribosome entry site (IRES) from the encephalomyocarditis (EMC) virus was able to abate protein synthesis in BSC1 cells by 25-fold, with as much as 30% of the remaining protein synthesis being NSP3.
Padilla-Noriega, Luis +2 more
openaire +2 more sources
Semliki Forest Virus-specific Non-structural Protein nsP3 Is a Phosphoprotein
Journal of General Virology, 1988 Antisera were raised in rabbits against fusion proteins consisting of beta-galactosidase and partial amino acid sequences of Semliki Forest virus (SFV)-specific non-structural proteins nsP1, nsP2, nsP3 and nsP4. The antisera were specific since each of them precipitated only one labelled protein of a size expected for nsP1, nsP2, nsP3 or nsP4 from ...
J, Peränen +3 more
openaire +2 more sources
Virology Journal, 2019 Background Transmissible gastroenteritis virus (TGEV), a member of the family Coronaviridae, causes lethal watery diarrhea in piglets. Previous studies have revealed that the coronaviruses develop various strategies to evade the host innate immunity ...
Yanan Wang +14 more
doaj +1 more source
The SARS-Coronavirus PLnc domain of nsp3 as a replication/transcription scaffolding protein
Virus Research, 2008 Many genetic and mechanistic features distinguish the coronavirus replication machinery from that encoded by most other RNA viruses. The coronavirus replication/transcription complex is an assembly of viral and, most probably, cellular proteins that mediate the synthesis of both the unusually large (approximately 30 kb) RNA genome and an extensive set ...
Imbert, Isabelle +5 more
openaire +2 more sources
Rotavirus Genome Segment 7 (NSP3) Is a Determinant of Extraintestinal Spread in the Neonatal Mouse [PDF]
Journal of Virology, 2002 ABSTRACT We used the neonatal mouse model of rotavirus infection to study extraintestinal spread following oral inoculation. Five-day-old pups were inoculated with either SA11-Cl3, SA11-Cl4, SA11-4F, RRV, or B223. By using virus detection in the liver as a proxy determination for extraintestinal spread, rotavirus strains capable ...
Eric C, Mossel, Robert F, Ramig
openaire +2 more sources
The Chikungunya Virus nsP3 Macro Domain Inhibits Activation of the NF-κB Pathway. [PDF]
Viruses, 2019 AbstractThe role of the chikungunya virus (CHIKV) non-structural protein 3 (nsP3) in the virus lifecycle is poorly understood. The protein comprises 3 domains. The N-terminus is a macro domain, biochemically characterised to bind both RNA and ADP-ribose, and to possess ADP-ribosyl hydrolase activity – an enzymatic activity that removes ADP-ribose from ...
Roberts GC, Stonehouse NJ, Harris M.
europepmc +5 more sources