Results 61 to 70 of about 14,750 (231)

Novel Functions of the Alphavirus Nonstructural Protein nsP3 C-Terminal Region [PDF]

Journal of Virology, 2010
ABSTRACT The functions of the alphavirus-encoded nonstructural protein nsP3 during infection are poorly understood. In contrast, nsP1, nsP2, and nsP4 have known enzymatic activities and functions. A functional analysis of the C-terminal region of nsP3 of Semliki Forest virus revealed the presence of a degradation signal that ...
Margus, Varjak, Eva, Zusinaite, Andres, Merits   +2 more
openaire   +2 more sources

Regulation of positive-strand RNA virus replication: The emerging role of phosphorylation. [PDF]

, 2007
Protein phosphorylation is a reversible post-translational modification that plays a fundamental role in the regulation of many cellular processes.
Jakubiec, Anna, Jupin, Isabelle
core   +3 more sources

Insighting isatin derivatives as potential antiviral agents against NSP3 of COVID-19

Chemical Papers, 2022
The world is now facing intolerable damage in all sectors of life because of the deadly COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2. The discovery and development of anti-SARS-CoV-2 drugs have become pragmatic in the time needed to fight against this pandemic.
Mubashar Ilyas, Shabbir Muhammad, Javed Iqbal, Saniyah Amin, Abdullah G. Al-Sehemi, H. Algarni, Saleh S. Alarfaji, Mohammad Y. Alshahrani, Khurshid Ayub   +8 more
openaire   +3 more sources

Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3

Viruses, 2021
Venezuelan equine encephalitis virus (VEEV) is a new world alphavirus and a category B select agent. Currently, no FDA-approved vaccines or therapeutics are available to treat VEEV exposure and resultant disease manifestations. The C-terminus of the VEEV
Allison Bakovic, Nishank Bhalla, Farhang Alem, Catherine Campbell, Weidong Zhou, Aarthi Narayanan   +5 more
doaj   +1 more source

Alphavirus nsP3 ADP-ribosylhydrolase Activity Disrupts Stress Granule Formation [PDF]

, 2019
ABSTRACTFormation of stress granules (SGs), cytoplasmic condensates of stalled translation initiation complexes, is regulated by post-translational protein modification. Alphaviruses interfere with SG formation in response to inhibition of host protein synthesis through the activities of nonstructural protein 3 (nsP3).
Jayabalan, Aravinth Kumar, Griffin, Diane E., Leung, Anthony K. L.   +2 more
openaire   +1 more source

Recognition of eIF4G by Rotavirus NSP3 Reveals a Basis for mRNA Circularization [PDF]

Molecular Cell, 2002
Rotaviruses, segmented double-stranded RNA viruses, co-opt the eukaryotic translation machinery with the aid of nonstructural protein 3 (NSP3), a rotaviral functional homolog of the cellular poly(A) binding protein (PABP). NSP3 binds to viral mRNA 3' consensus sequences and circularizes mRNA via interactions with eIF4G.
Groft, Caroline M., Burley, Stephen K.
openaire   +2 more sources

Antiviral activity of silymarin against chikungunya virus [PDF]

, 2015
Citation: Lani, R., Hassandarvish, P., Chiam, C. W., Moghaddam, E., Chu, J. J. H., Rausalu, K., . . . Zandi, K. (2015). Antiviral activity of silymarin against chikungunya virus. Scientific Reports, 5, 10.
Abu Bakar, S., Chiam, C. W., Chu, J. J. H., Hassandarvish, P., Higgs, Stephen, Lani, R., Merits, A., Moghaddam, E., Rausalu, K., Vanlandingham, Dana, Zandi, K.   +10 more
core   +1 more source

Consequences of Zeeman Degeneracy for van der Waals Blockade between Rydberg Atoms

, 2007
We analyze the effects of Zeeman degeneracies on the long-range interactions between like Rydberg atoms, with particular emphasis on applications to quantum information processing using van der Waals blockade.
A. Burgess, D. A. Varshalovich, L. I. Schiff, M. Saffman, Thad G. Walker   +4 more
core   +1 more source

Semliki Forest Virus-specific Non-structural Protein nsP3 Is a Phosphoprotein

Journal of General Virology, 1988
Antisera were raised in rabbits against fusion proteins consisting of beta-galactosidase and partial amino acid sequences of Semliki Forest virus (SFV)-specific non-structural proteins nsP1, nsP2, nsP3 and nsP4. The antisera were specific since each of them precipitated only one labelled protein of a size expected for nsP1, nsP2, nsP3 or nsP4 from ...
J, Peränen, K, Takkinen, N, Kalkkinen, L, Kääriäinen   +3 more
openaire   +2 more sources

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source