Results 71 to 80 of about 9,413 (173)

Development of a theoretical model for the inhibition of nsP3 of Chikungunya virus using pyranooxazoles

open access: yesJournal of Biomolecular Structure and Dynamics, 2019
Chikungunya virus (CHIKV) causes Chikungunya fever (CHIKF) and till date no effective medicine for its cure is available in market. Different research groups find various possible interactions between small molecules and non-structural proteins, viz. nsP3, one of the most important viral elements in CHIKV.
Durgesh, Kumar   +3 more
openaire   +2 more sources

Alphavirus nsP3 functions to form replication complexes transcribing negative-strand RNA [PDF]

open access: yesJournal of Virology, 1994
The alphavirus mutant Sindbis virus HR ts4, which has been assigned to the A complementation group, possessed a selective defect in negative-strand synthesis that was similar although not identical to that observed for the B complementation group mutant ts11 (Y.-F. Wang, S. G. Sawicki, and D. L. Sawicki, J. Virol. 65:985-988, 1991). The causal mutation
Y F, Wang, S G, Sawicki, D L, Sawicki
openaire   +2 more sources

NMR assignment of the nonstructural protein nsp3(1066–1181) from SARS-CoV [PDF]

open access: yesBiomolecular NMR Assignments, 2008
Sequence-specific NMR assignments of the globular core comprising the residues 1066-1181 within the non-structural protein nsp3e from the SARS coronavirus have been obtained using triple-resonance NMR experiments with the uniformly [(13)C, (15)N]-labeled protein.
Serrano, Pedro   +4 more
openaire   +2 more sources

An ncRNA transcriptomics-based approach to design siRNA molecules against SARS-CoV-2 double membrane vesicle formation and accessory genes

open access: yesBMC Infectious Diseases, 2023
Background The corona virus SARS-CoV-2 is the causative agent of recent most global pandemic. Its genome encodes various proteins categorized as non-structural, accessory, and structural proteins.
Rabia Nawaz   +10 more
doaj   +1 more source

Different Types of nsP3-Containing Protein Complexes in Sindbis Virus-Infected Cells [PDF]

open access: yesJournal of Virology, 2008
ABSTRACT Alphaviruses represent a serious public health threat and cause a wide variety of diseases, ranging from severe encephalitis, which can result in death or neurological sequelae, to mild infection, characterized by fever, skin rashes, and arthritis.
Rodion, Gorchakov   +3 more
openaire   +2 more sources

Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3 [PDF]

open access: bronze, 2020
David N. Frick   +4 more
openalex   +1 more source

Venezuelan equine encephalitis virus non-structural protein 3 dictates superinfection exclusion in mammalian cells

open access: yesnpj Viruses
Superinfection exclusion (SIE) prevents secondary infections of already infected cells. Arthritogenic alphaviruses induce SIE via early proteolytical cleavage of replicase precursor by non-structural protein 2 (nsP2).
Tessy A. H. Hick   +5 more
doaj   +1 more source

Home - About - Disclaimer - Privacy