Results 71 to 80 of about 14,750 (231)

Nsp3-N interactions are critical for SARS-CoV-2 fitness and virulence

Proceedings of the National Academy of Sciences, 2023
SARS-CoV-2, the causative agent of COVID-19 encodes at least 16 nonstructural proteins of variably understood function. Nsp3, the largest nonstructural protein contains several domains, including a SARS-unique domain (SUD), which occurs only in Sarbecovirus .
Pengfei Li, Biyun Xue, Nicholas J. Schnicker, Lok-Yin Roy Wong, David K. Meyerholz, Stanley Perlman   +5 more
openaire   +2 more sources

Genome-wide analysis of protein–protein interactions and involvement of viral proteins in SARS-CoV-2 replication

Cell & Bioscience, 2021
Background Analysis of viral protein–protein interactions is an essential step to uncover the viral protein functions and the molecular mechanism for the assembly of a viral protein complex.
Yiling Jiang, Kuijie Tong, Roubin Yao, Yuanze Zhou, Hanwen Lin, Liubing Du, Yunyun Jin, Liu Cao, Jingquan Tan, Xing-Ding Zhang, Deyin Guo, Ji-An Pan, Xiaoxue Peng   +12 more
doaj   +1 more source

Mapping of RNA- temperature-sensitive mutants of Sindbis virus: assignment of complementation groups A, B, and G to nonstructural proteins [PDF]

, 1989
Four complementation groups of temperature-sensitive (ts) mutants of Sindbis virus that fail to make RNA at the nonpermissive temperature are known, and we have previously shown that group F mutants have defects in nsP4.
Hahn, Young S., Strauss, Ellen G., Strauss, James H.   +2 more
core   +1 more source

Toward Dual‐Function Nanoparticle Platforms for Arboviral Diagnostics and Vaccines: Advances, Challenges, and Future Prospects

Nano Select, Volume 7, Issue 2, February 2026.
This review explores nanoparticle (NP)‐based biosensors and nanovaccine platforms for arboviral infections, highlighting their design, performance, and translational potential. By comparing case studies across viruses, it identifies gold‐standard nanomaterials such as gold NPs (AuNPs), zinc oxide NPs (ZnONPs), molybdenum disulfide (MoS2) nanocomposites,
Peyman Halvaeikhanekahdani, Sajad Zandi, Qadeer Ahmad, Hadiseh Payravand   +3 more
wiley   +1 more source

Recognition of the Rotavirus mRNA 3′ Consensus by an Asymmetric NSP3 Homodimer [PDF]

Cell, 2002
Rotaviruses, the cause of life-threatening diarrhea in humans and cattle, utilize a functional homolog of poly(A) binding protein (PABP) known as nonstructural protein 3 (NSP3) for translation of viral mRNAs. NSP3 binds to viral mRNA 3' consensus sequences and circularizes the mRNA via interactions with eIF4G.
Deo, Rahul C., Groft, Caroline M., Rajashankar, K.R., Burley, Stephen K.   +3 more
openaire   +2 more sources

SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

Emerging Microbes and Infections, 2021
The genome of SARS-CoV-2 encodes two viral proteases (NSP3/papain-like protease and NSP5/3C-like protease) that are responsible for cleaving viral polyproteins during replication.
Mehdi Moustaqil, Emma Ollivier, Hsin-Ping Chiu, Sarah Van Tol, Paulina Rudolffi-Soto, Christian Stevens, Akshay Bhumkar, Dominic J. B. Hunter, Alexander N. Freiberg, David Jacques, Benhur Lee, Emma Sierecki, Yann Gambin   +12 more
doaj   +1 more source

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China. [PDF]

, 2020
An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses.
Cheng, Genhong, Ding, Xiao, Huang, Baoying, Jiang, Taijiao, Meng, Jing, Niu, Peihua, Peng, Yousong, Quan, Lijun, Sheng, Jie, Tan, Wenjie, Wang, Jiangyuan, Wang, Xianyue, Wu, Aiping, Xia, Zanxian, Zhang, Zheng, Zhu, Zhaozhong   +15 more
core  

RNAi Regulator C3PO Promotes Arbovirus Infection in Insect Vectors

Advanced Science, Volume 13, Issue 4, 19 January 2026.
RNA interference (RNAi) is vital for eukaryotes to defend against virus infection. The C3PO complex takes part in RNAi but its role in regulating viral infection remains unclear. This work finds that insect C3PO facilitates arbovirus replication by degrading precursors of miRNAs, especially miR‐971‐3p.
Yan Xiao, Tianyu Guan, Qianfeng Xia, Chen Chen, Qian Wang, Lan Luo, Hong Lu, Feng Cui   +7 more
wiley   +1 more source

NMR assignment of the nonstructural protein nsp3(1066–1181) from SARS-CoV [PDF]

Biomolecular NMR Assignments, 2008
Sequence-specific NMR assignments of the globular core comprising the residues 1066-1181 within the non-structural protein nsp3e from the SARS coronavirus have been obtained using triple-resonance NMR experiments with the uniformly [(13)C, (15)N]-labeled protein.
Serrano, Pedro, Johnson, Margaret A., Chatterjee, Amarnath, Pedrini, Bill, Wüthrich, Kurt   +4 more
openaire   +2 more sources

Novel NMR Assignment Strategy Reveals Structural Heterogeneity in Solution of the nsP3 HVD Domain of Venezuelan Equine Encephalitis Virus

Molecules, 2020
In recent years, intrinsically disordered proteins (IDPs) and disordered domains have attracted great attention. Many of them contain linear motifs that mediate interactions with other factors during formation of multicomponent protein complexes.
Peter Agback, Andrey Shernyukov, Francisco Dominguez, Tatiana Agback, Elena I. Frolova   +4 more
doaj   +1 more source