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Chikungunya virus (CHIKV) causes Chikungunya fever (CHIKF) and till date no effective medicine for its cure is available in market. Different research groups find various possible interactions between small molecules and non-structural proteins, viz. nsP3, one of the most important viral elements in CHIKV.
Durgesh, Kumar +3 more
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Alphavirus nsP3 functions to form replication complexes transcribing negative-strand RNA [PDF]
The alphavirus mutant Sindbis virus HR ts4, which has been assigned to the A complementation group, possessed a selective defect in negative-strand synthesis that was similar although not identical to that observed for the B complementation group mutant ts11 (Y.-F. Wang, S. G. Sawicki, and D. L. Sawicki, J. Virol. 65:985-988, 1991). The causal mutation
Y F, Wang, S G, Sawicki, D L, Sawicki
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The percentages of SARS-CoV-2 protein similarity and identity with SARS-CoV and BatCoV RaTG13 proteins can be used as indicators of virus origin 1ab Polyprotein · Spike protein · Envelope protein · nsp3 · orf10 [PDF]
Mohammed Elimam Ahamed Mohammed +2 more
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NMR assignment of the nonstructural protein nsp3(1066–1181) from SARS-CoV [PDF]
Sequence-specific NMR assignments of the globular core comprising the residues 1066-1181 within the non-structural protein nsp3e from the SARS coronavirus have been obtained using triple-resonance NMR experiments with the uniformly [(13)C, (15)N]-labeled protein.
Serrano, Pedro +4 more
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Background The corona virus SARS-CoV-2 is the causative agent of recent most global pandemic. Its genome encodes various proteins categorized as non-structural, accessory, and structural proteins.
Rabia Nawaz +10 more
doaj +1 more source
Different Types of nsP3-Containing Protein Complexes in Sindbis Virus-Infected Cells [PDF]
ABSTRACT Alphaviruses represent a serious public health threat and cause a wide variety of diseases, ranging from severe encephalitis, which can result in death or neurological sequelae, to mild infection, characterized by fever, skin rashes, and arthritis.
Rodion, Gorchakov +3 more
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Analysis Crystal Structure of Sars-cov-2 Nsp3 Macrodomain Based on Optimal Multi Level of Deep Neurocomputing Technique [PDF]
Samaher Al-Janabi, Ayad F. Alkaim
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Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3 [PDF]
David N. Frick +4 more
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Superinfection exclusion (SIE) prevents secondary infections of already infected cells. Arthritogenic alphaviruses induce SIE via early proteolytical cleavage of replicase precursor by non-structural protein 2 (nsP2).
Tessy A. H. Hick +5 more
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