Results 81 to 90 of about 14,750 (231)

Detection and Characterization of Sindbis Virus Genotype IV in Mosquitoes From Slovenia

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Mosquitoes play a crucial role as vectors of disease pathogens and are among the most socioeconomically important animals in the world. Medically important arboviruses include the Sindbis virus (SINV), which causes chills, skin rashes, and joint pain. Endemic in northern Europe, SINV has been increasingly detected in central Europe. The main objectives
Patricija Pozvek, Miša Korva, Samo Zakotnik, Tea Knapič, Katja Adam, Katarina Resman Rus, Gašper Grubelnik, Tomi Trilar, Vladimir Ivović, Tatjana Avšič-Županc, Nataša Knap, Efstathios Giotis S   +11 more
wiley   +1 more source

Fostering Equitable Foreclosure Recovery [PDF]

, 2012
This report provides essential information to inform policy discussions about foreclosure recovery. It presents information about the foreclosure crisis and its consequences, describes the federal program created to help communities recover from the ...
Jennifer Tran, Kalima Rose, Srah Treuhaft   +2 more
core  

The interferon-induced exonuclease ISG20 exerts antiviral activity through upregulation of type I interferon response proteins [PDF]

, 2018
The host immune responses to infection lead to the production of type I interferon (IFN), and the upregulation of interferon-stimulated genes (ISGs) reduces virus replication and virus dissemination within a host.
Diamond, Michael S, Klimstra, William B, Lucas, Tiffany M, Ryman, Kate D, Sun, Chengqun, Trobaugh, Derek W, Weiss, Christopher M   +6 more
core   +2 more sources

Different Types of nsP3-Containing Protein Complexes in Sindbis Virus-Infected Cells [PDF]

Journal of Virology, 2008
ABSTRACT Alphaviruses represent a serious public health threat and cause a wide variety of diseases, ranging from severe encephalitis, which can result in death or neurological sequelae, to mild infection, characterized by fever, skin rashes, and arthritis.
Rodion, Gorchakov, Natalia, Garmashova, Elena, Frolova, Ilya, Frolov   +3 more
openaire   +2 more sources

Discovery of Drug-like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3 [PDF]

SLAS Discovery, 2020
ABSTRACTSmall molecules that bind the SARS-CoV-2 non-structural protein 3 Mac1 domain in place of ADP-ribose could be useful as molecular probes or scaffolds for COVID-19 antiviral drug discovery because Mac1 has been linked to coronavirus’ ability to evade cellular detection. A high-throughput assay based on differential scanning fluorimetry (DSF) was
Rajdeep S. Virdi, Robert V. Bavisotto, Nicholas C. Hopper, Nemanja Vuksanovic, Trevor R. Melkonian, Nicholas R. Silvaggi, David N. Frick   +6 more
openaire   +5 more sources

Identification of TPRA1 as a Novel Receptor and Predictive Biomarker for Oncolytic Virus M1

Advanced Science, Volume 12, Issue 48, December 29, 2025.
This study identifies transmembrane protein adipocyte‐associated 1 (TPRA1) as a novel receptor for oncolytic virus M1 (OVM). TPRA1's ectodomain binds OVM particles, while its intracellular domain facilitates virus internalization, promoting efficient viral entry.
Linyi Hu, Guigen Zhang, Yuan Lin, Shiming Yi, Jingyu Yang, Xueying Lin, Deli Song, Zhiheng Liu, Jiayu Zhang, Ying Zeng, Shanyu Huang, Zhen Fan, Jifu Zhang, Ying Liu, Cheng Hu, Wenbo Zhu, Wei Yin, Jun Hu, Guangmei Yan, Jing Cai, Jiankai Liang   +20 more
wiley   +1 more source

READDI protocol: Crystallisation of CHIKV nsP3 macrodomain v1

Chikungunya virus (CHIKV) causes severe fever, rash and debilitating joint pain that can last for months or even years. Millions of people have been infected with CHIKV, mostly in low- and middle-income countries, and the virus continues to spread into new areas due to the geographical expansion of its mosquito hosts.
Jasmin Aschenbrenner, Peter Marples, michael fairhead, Andre Schutzer de Godoy, Daren Fearon   +4 more
openaire   +2 more sources

High-resolution functional mapping of the venezuelan equine encephalitis virus genome by insertional mutagenesis and massively parallel sequencing. [PDF]

PLoS Pathogens, 2010
We have developed a high-resolution genomic mapping technique that combines transposon-mediated insertional mutagenesis with either capillary electrophoresis or massively parallel sequencing to identify functionally important regions of the Venezuelan ...
Brett F Beitzel, Russell R Bakken, Jeffrey M Smith, Connie S Schmaljohn   +3 more
doaj   +1 more source

Membrane binding proteins of coronaviruses [PDF]

, 2019
Coronaviruses (CoVs) infect many species causing a variety of diseases with a range of severities. Their members include zoonotic viruses with pandemic potential where therapeutic options are currently limited.
Entedar A J Alsaadi, Ian M Jones, Klumperman J, Millet JK   +3 more
core   +1 more source

Five‐Year (2017–2022) Evolutionary Dynamics of Human Coronavirus OC43 in Southern France Based on Whole Genome Next‐Generation Sequencing

Journal of Medical Virology, Volume 97, Issue 12, December 2025.
ABSTRACT HCoV‐OC43 genomes and their evolution are scarcely studied worldwide and in France, with only 361 genomes available as of October 2023. Here, an in‐house PCR amplification system was implemented to obtain retrospectively by next‐generation sequencing, then analyze HCoV‐OC43 genomes for infections diagnosed with this virus in southern France ...
Hikmat Houmadi, Céline Boschi, Marine Lefebvre, Lorlane Le Targa, Justine Py, Jean‐Christophe Lagier, Lucile Lesage, Jacques Fantini, Aurélie Morand, Bernard La Scola, Philippe Colson   +10 more
wiley   +1 more source