Results 111 to 120 of about 16,210 (241)

A mechanistic‐based normal tissue complication probability (NTCP) prediction through a microdosimetry‐based multiscale radiation biophysical model (MS‐GSM2)

Precision Radiation Oncology, EarlyView.
Marco Battestini, Marta Missiaggia, Giulio Bordieri, Jules Morand, Emanuele Scifoni, Francesco Giuseppe Cordoni   +5 more
wiley   +1 more source

The pharmacology of gepants in migraine: A scoping review on mechanisms, clinical applications, and combination strategies

Headache: The Journal of Head and Face Pain, Volume 66, Issue 7, Page 1628-1643, July/August 2026.
Abstract Background Calcitonin gene‐related peptide (CGRP) is a key mediator in migraine pathophysiology, and the development of gepants, novel CGRP receptor antagonists, has expanded therapeutic options for both acute and preventive treatment. This scoping review aims to synthesize current evidence on the pharmacology, clinical applications, safety ...
Luigi Francesco Iannone, Marcello Silvestro, Antonio Munafò, Marina Romozzi, Pierangelo Geppetti, Antonio Russo   +5 more
wiley   +1 more source

The dose–response characteristics of four NTCP models: using a novel CT-based radiomic method to quantify radiation-induced lung density changes

Scientific Reports, 2020
Multiple competing normal tissue complication probability (NTCP) models have been proposed for predicting symptomatic radiation-induced lung injury in human.
Dustin Begosh-Mayne, Shruti Kumar, Steven Toffel, P. Okunieff, W. O'Dell   +4 more
semanticscholar   +1 more source

Genotypes of Hepatitis B and D Viruses Among Patients With Hepatitis D in the United States

Journal of Viral Hepatitis, Volume 33, Issue 7, July 2026.
ABSTRACT The epidemiological landscape of paired hepatitis B virus (HBV)/hepatitis delta virus (HDV) genotype (GT) among patients with HDV in the US remains unknown. HBV/HDV genotypes were assessed in two independent US cohorts: Cohort 1 included 5222 HBV‐positive patients from Quest Diagnostics, including 114 anti‐HDV+ patients; Cohort 2 included 178 ...
Andrew Lopez, Harish Gopalakrishna, Silvia Chang, Savrina Manhas, Nadine Peinovich, Christopher Richards, Grace Chee, Ross Martin, Roberto Mateo, Maria Mironova, Brooke E. Swanson, William A. Meyer III, Elizabeth M. Marlowe, Chunfeng Li, Hongmei Mo, Theo Heller, Evguenia Maiorova, Christopher Koh   +17 more
wiley   +1 more source

Innovative HBV Animal Models Based on the Entry Receptor NTCP

Viruses, 2020
Hepatitis B is a major global health problem, with an estimated 257 million chronically infected patients and almost 1 million deaths per year. The causative agent is hepatitis B virus (HBV), a small, enveloped, partially double-stranded DNA virus.
J. Wettengel, B. Burwitz
semanticscholar   +1 more source

An integrated strategy of biological and physical constraints in biological optimization for cervical carcinoma

Radiation Oncology, 2017
Background For cervical carcinoma cases, this study aimed to evaluate the quality of intensity-modulated radiation therapy (IMRT) plans optimized by biological constraints. Furthermore, a new integrated strategy in biological planning module was proposed
Ziwei Feng, Cheng Tao, Jian Zhu, Jinhu Chen, Gang Yu, Shaohua Qin, Yong Yin, Dengwang Li   +7 more
doaj   +1 more source

Brainstem NTCP and Dose Constraints for Carbon Ion RT—Application and Translation From Japanese to European RBE-Weighted Dose

Frontiers in Oncology, 2020
Background and Purpose The Italian National Center of Oncological Hadrontherapy (CNAO) has applied dose constraints for carbon ion RT (CIRT) as defined by Japan’s National Institute of Radiological Sciences (NIRS).
J. E. Dale, S. Molinelli, B. Vischioni, V. Vitolo, M. Bonora, G. Magro, A. Mairani, A. Hasegawa, T. Ohno, O. Dahl, F. Valvo, P. Fossati   +11 more
semanticscholar   +1 more source

Human NTCP transgenic (hNTCP-Tg) C57BL/6 mice. [PDF]

, 2015
(A) Schematic diagram of human NTCP transgene introduced into mouse genome. Expression of hNTCP was controlled by a mouse albumin enhancer/promoter with a Bovine Growth Hormone (BGH) polyadenylation signal.
Fengfeng Mao (331975), Bijie Ren (728288), Ju-Tao Guo (304340), Fengchao Wang (506135), Yang Liu (4829), Wenhui He (584851), Yinyan Sun (728290), Wenhui Li (396116), Yunfei Li (652635), Yonghe Qi (457796), Jianhua Sui (53799), Bo Peng (273834), Zhiyi Jing (728289), Huan Yan (445452)   +13 more
core   +1 more source

Cell survival comparison of proton, helium, and carbon ion interlaced minibeams in water phantom simulations

Medical Physics, Volume 53, Issue 6, June 2026.
Abstract Background Radiotherapy is a key in cancer treatment, with particle therapy providing better tumor targeting and sparing healthy tissues. Particle Minibeam Radiotherapy (PMBT) integrates the advantages of spatial fractionation into particle radiotherapy by employing submillimeter‐sized beams, thus improving the therapeutic ratio by reducing ...
Aikaterini Rousseti, Günther Dollinger, Judith Reindl   +2 more
wiley   +1 more source

Down-regulation of cell membrane localized NTCP expression in proliferating hepatocytes prevents hepatitis B virus infection

Emerging Microbes and Infections, 2019
Hepatocyte proliferation could result in the loss of covalently closed circular DNA (cccDNA) and the emergence of cccDNA-cleared nascent hepatocytes, which appear refractory to hepatitis B virus (HBV) reinfection with unknown mechanism(s).
Ying Yan, Lena Allweiss, Danli Yang, Jingting Kang, Jianwen Wang, Xiangjun Qian, Ting Zhang, Hui Liu, Lu Wang, Shuhong Liu, Jianhua Sui, Xiangmei Chen, Maura Dandri, Jingmin Zhao, Fengmin Lu   +14 more
doaj   +1 more source