Results 101 to 110 of about 16,210 (241)

From Diagnosis to Durability: A Review of the European Bulevirtide Experience and Practical Learnings for CHD Management

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Hepatitis delta virus (HDV) infection causes chronic hepatitis D (CHD), the most severe form of chronic viral hepatitis with a high risk of progression to advanced liver disease. Off‐label pegylated interferon alpha was the primary treatment option in Europe prior to the introduction of bulevirtide, a first‐in‐class HDV entry inhibitor.
Monica Radu, Margarita Papatheodoridi, Habiba Kamal Khodir, Sabela Lens, Elisabetta Degasperi, Speranta Iacob, Liliana Gheorghe, Katja Steppich, Florin Alexandru Caruntu, Pietro Lampertico, Soo Aleman, Heiner Wedemeyer   +11 more
wiley   +1 more source

Use of Indocyanine Green (ICG), a Medical Near Infrared Dye, for Enhanced Fluorescent Imaging—Comparison of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) and Sodium-Taurocholate Cotransporting Polypeptide (NTCP) Reporter Genes

Molecules, 2019
Molecular and cellular imaging in living organisms have ushered in an era of comprehensive understanding of intracellular and intercellular events. Currently, more efforts have been focused on the infrared fluorescent dyes that facilitate deeper tissue ...
Menq-Rong Wu, Yi-You Huang, Jong-Kai Hsiao   +2 more
doaj   +1 more source

Conditional sparing in FLASH radiotherapy: Conformal dosimetry and ALARA remain essential

Journal of Applied Clinical Medical Physics, Volume 27, Issue 7, July 2026.
Abstract FLASH radiotherapy shows promise in reducing normal tissue toxicity while maintaining tumor control. However, preclinical and early clinical evidence reveal biological and technical uncertainties. We review preclinical and veterinary studies, highlight unexpected toxicities, and argue that the fundamental principles of precision and safety in ...
Chih‐Chiang Chang, Yangguang Ma, Minglei Kang, Bhudatt Paliwal, Zachary Morris, Benjamin Durkee, Chingyun Cheng   +6 more
wiley   +1 more source

Long-term trans-inhibition of the hepatitis B and D virus receptor NTCP by taurolithocholic acid.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2020
Human hepatic bile acid transporter Na+/taurocholate co-transporting polypeptide (NTCP) represents the liver-specific entry receptor for the Hepatitis B and D Viruses (HBV/HDV).
K. A. A. T. Lowjaga, Michael Kirstgen, S. F. Müller, Nora Goldmann, Felix Lehmann, D. Glebe, J. Geyer   +6 more
semanticscholar   +1 more source

Kinetics of the bile acid transporter and hepatitis B virus receptor Na+/taurocholate cotransporting polypeptide (NTCP) in hepatocytes [PDF]

, 2014
Background & AimsThe human liver bile acid transporter Na+/taurocholate cotransporting polypeptide (NTCP) has recently been identified as liver-specific receptor for infection of hepatitis B virus (HBV), which attaches via the myristoylated preS1 (myr ...
Mohr, Christina, Glebe, Dieter, Döring, Barbara, Geyer, Joachim, König, Alexander, Geipel, Andreas   +5 more
core   +1 more source

Development and evaluation of an in vivo dose‐based monitoring system for electron FLASH radiation therapy

Medical Physics, Volume 53, Issue 7, July 2026.
Abstract Background FLASH radiotherapy requires further preclinical and clinical investigation to establish its biological effectiveness and define optimal beam parameters. In conventional (CONV) radiotherapy, redundant beam termination systems are a cornerstone ensuring patient safety, yet analogous safeguards for FLASH delivery are not well ...
Justin DeFrancisco, Matthew Richeson, Tomaj Javidtash, Chris Bartee, Tianjun Ma, Siyong Kim   +5 more
wiley   +1 more source

Hepatitis B virus-targeting sodium taurocholate cotransporting polypeptide mediates HBV infection and damage in human renal podocytes

Microbiology Spectrum
Hepatitis B virus (HBV) may directly infect human podocytes (HPCs). However, the mechanism of direct infection is unclear. We found that HPCs express sodium taurocholate cotransporting polypeptide (NTCP), a specific receptor for HBV entry into ...
Lifen Wang, Cheng Wang, Xu Wang, Yantao Cao, Xiaohua Guo, Zhiming Ye   +5 more
doaj   +1 more source

Correlation of Bile Acid Dynamics to Bulevirtide Response and Disease Severity in Patients With Hepatitis D

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 2, Page 196-207, July 2026.
Bulevirtide increases bile acid levels in most patients; however, changes in bile acids do not predict virological response or adverse events, nor do they reflect treatment adherence. After discontinuation of bulevirtide, bile acid levels rapidly decline.
Marlene Hintersteininger, Michael Schwarz, Philipp Schwabl, Lukas Hartl, Lorenz Balcar, Benedikt Silvester Hofer, Georg Kramer, Christian Sebesta, Paul Thöne, Patrik Attalla, Michael Gschwantler, Michael Trauner, Mattias Mandorfer, Thomas Reiberger, Mathias Jachs   +14 more
wiley   +1 more source

Spinoculation Enhances HBV Infection in NTCP-Reconstituted Hepatocytes

PLOS ONE, 2015
Hepatitis B virus (HBV) infection and its sequelae remain a major public health burden, but both HBV basic research and the development of antiviral therapeutics have been hindered by the lack of an efficient in vitro infection system. Recently, sodium taurocholate cotransporting polypeptide (NTCP) has been identified as the HBV receptor.
Yan, Ran, Zhang, Yongmei, Cai, Dawei, Liu, Yuanjie, Cuconati, Andrea, Guo, Haitao   +5 more
openaire   +4 more sources

NTCP expression in HepG2-NTCP12 cells. [PDF]

, 2015
The stable expression of C9-tagged NTCP in HepG2-NTCP12 cells were detected by Western blot (A) and immunofluorescence microscopy (B) using antibody against C9 epitope. The parental HepG2 cells served as negative control.
Dawei Cai (433179), Ran Yan (433180), Haitao Guo (276341), Andrea Cuconati (276334), Yuanjie Liu (203485), Yongmei Zhang (16501)   +5 more
core   +1 more source