Results 91 to 100 of about 16,210 (241)

Hepatic bile salt uptake: The role of NTCP revisited [PDF]

, 2019
NTCP is een cruciale transporter van geconjugeerde galzouten binnen de enterohepatische kringloop van galzouten. Wij hebben diens functioneren onderzocht in een NTCP-knockout muis en met een specifieke farmacologische NTCP-remmer myrcludex B.
Slijepčević, D., Slijepčević, Davor
core   +2 more sources

Nitric oxide-mediated inhibition of taurocholate uptake involvesS-nitrosylation of NTCP [PDF]

, 2011
The sodium-taurocholate (TC) cotransporting polypeptide (NTCP) facilitates bile formation by mediating sinusoidal Na+-TC cotransport. During sepsis-induced cholestasis, there is a decrease in NTCP-dependent uptake of bile acids and an increase in nitric ...
Umadevi Ramasamy, M. Sawkat Anwer, Christopher M. Schonhoff   +2 more
core   +1 more source

Systematic reduction of hyperspectral images for high-throughput plastic characterization

Scientific Reports, 2023
Hyperspectral Imaging (HSI) combines microscopy and spectroscopy to assess the spatial distribution of spectroscopically active compounds in objects, and has diverse applications in food quality control, pharmaceutical processes, and waste sorting ...
Mahdiyeh Ghaffari, Mickey C. J. Lukkien, Nematollah Omidikia, Gerjen H. Tinnevelt, Marcel C. P. van Eijk, Stanislav Podchezertsev, Jeroen J. Jansen   +6 more
doaj   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

NTCP Models for Severe Radiation Induced Dermatitis After IMRT or Proton Therapy for Thoracic Cancer Patients

Frontiers in Oncology, 2020
Radiation therapy (RT) of thoracic cancers may cause severe radiation dermatitis (RD), which impacts on the quality of a patient's life. Aim of this study was to analyze the incidence of acute RD and develop normal tissue complication probability (NTCP ...
G. Palma, S. Monti, M. Conson, T. Xu, S. Hahn, M. Durante, R. Mohan, Z. Liao, L. Cella   +8 more
semanticscholar   +1 more source

Localization of amino acid 158 at human NTCP. [PDF]

, 2018
Homology model of human NTCP based on the crystal structure of ASBTYf [22]. The model represents amino acids 27–308 of NTCP. The panel domain is depicted in light and the core domain in dark grey. Localisation of the protein within the plasma membrane is
Simon F. Müller (5410238), Dieter Glebe (421759), Barbara Döring (411340), Joachim Geyer (411344), Alexander König (2526433)   +4 more
core   +1 more source

Rare Variants in PFIC‐Related Genes Among Adults With Intrahepatic Cholestasis

Hepatology Research, EarlyView.
ABSTRACT Aim Biallelic pathogenic variants in progressive familial intrahepatic cholestasis (PFIC)‐related genes cause severe pediatric cholestasis. However, the clinical significance of heterozygous variants in adult intrahepatic cholestasis remains unclear.
Shunji Hirose, Kota Tsuruya, Yusuke Mishima, Yoshitaka Arase, Koichi Shiraishi, Vu Thi Hao, Satsuki Ieda, Masayuki Tanaka, Sanae Isaki, Tatehiro Kagawa   +9 more
wiley   +1 more source

Establishment of a human cell line with a surface display system for screening and optimizing Na+-taurocholate cotransporting polypeptide-binding peptides

Frontiers in Microbiology, 2022
One of the most desirable targets for HBV medications is the sodium taurocholate cotransporting polypeptide (NTCP), an entry receptor for the hepatitis B virus (HBV). N-myristoylated preS1 2–48 (Myrcludex B or Hepcludex), an NTCP-binding peptide from the
Pei-yun Wang, Xue Yang, Lin Guo, Yu-wei Wang, Yu-wei Wang, Wen-lu Zhang, Yu-xue Sun, Jie Li, Chun-yang Gan, Shao-yuan Long, Jia-jun Liu, Shu-ying Fan, Ai-long Huang, Jie-Li Hu   +13 more
doaj   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

Using Pharmacovigilance Data for Signal Detection of Drug Interactions for Rosuvastatin

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
ABSTRACT The 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase inhibitor rosuvastatin is a substrate of breast cancer resistance protein (BCRP). BCRP inhibition increases rosuvastatin plasma concentrations and may result in concentration‐dependent muscle toxicity, at worst rhabdomyolysis.
Ronja Levomäki, Päivi Hirvensalo, Aleksi Tornio, Anne M. Filppula   +3 more
wiley   +1 more source