Results 91 to 100 of about 9,177 (185)

NTCP deficiency in mice protects against obesity and hepatosteatosis

JCI Insight, 2019
Bile acids play a major role in the regulation of lipid and energy metabolism. Here we propose the hepatic bile acid uptake transporter Na + taurocholate cotransporting polypeptide (NTCP) as a target to prolong postprandial bile acid elevations in plasma.
Joanne M. Donkers, Sander Kooijman, Davor Slijepcevic, Roni F. Kunst, Reinout L.P. Roscam Abbing, Lizette Haazen, Dirk R. de Waart, Johannes H.M. Levels, Kristina Schoonjans, Patrick C.N. Rensen, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf   +11 more
openaire   +4 more sources

Identification of NTCP animal orthologs supporting hepatitis B virus binding and infection

Journal of Virology
Hepatitis B virus (HBV) infection is a significant global health threat, resulting in more than 800,000 deaths annually. Since HBV naturally infects only humans and chimpanzees, the development and evaluation of new therapies for chronic HBV infection ...
Fuwang Chen, Jochen M. Wettengel, Florian Gegenfurtner, Judith Moosmüller, Till Bunse, Samuel D. Jeske, Philipp Hagen, Yi Ni, Stephan Urban, Ulrike Protzer   +9 more
doaj   +1 more source

Radiation pneumonitis and NTCP models [PDF]

International Journal of Radiation Oncology*Biology*Physics, 2001
J.V. Lebesque, Y. Seppenwoolde, J.S. Belderbos, K. de Jaeger, G.T. Henning, J.A. Hayman, M.K. Martel, R.K. Ten Haken   +7 more
openaire   +1 more source

Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP

Nature Communications
Cellular entry of the hepatitis B and D viruses (HBV/HDV) requires binding of the viral surface polypeptide preS1 to the hepatobiliary transporter Na+-taurocholate co-transporting polypeptide (NTCP).
Hongtao Liu, Dariusz Zakrzewicz, Kamil Nosol, Rossitza N. Irobalieva, Somnath Mukherjee, Rose Bang-Sørensen, Nora Goldmann, Sebastian Kunz, Lorenzo Rossi, Anthony A. Kossiakoff, Stephan Urban, Dieter Glebe, Joachim Geyer, Kaspar P. Locher   +13 more
doaj   +1 more source

Prognostic Value of NTCP p.Ser267Phe Variant in Patients with Chronic Hepatitis B

Namık Kemal Tıp Dergisi
Aim: In this study, the aim is to detect polymorphisms in the gene encoding the sodium taurocholate cotransporting polypeptide (NTCP), the functional receptor for hepatitis B virus (HBV) and hepatitis D virus.
Bülent ÇAKAL, Alp ATASOY, Mehveş PODA, Bilger ÇAVUŞ, Mesut BULAKÇI, Mine GÜLLÜOĞLU, Filiz AKYÜZ   +6 more
doaj   +1 more source

Unlocking the secrets to human NTCP structure

The Innovation, 2022
Xiangbing Qi, Wenhui Li
openaire   +2 more sources

SELECTION OF THE OPTIMAL PRIOR FOR BAYESIAN NTCP CALCULATION

Radiotherapy and Oncology, 2009
Schilstra, C., Van der Schaaf, A., Langendijk, J. A., van 't Veld, A.   +3 more
openaire   +2 more sources

Robustness of tumor control (TCP) and normal tissue complication probabilities (NTCP) for intensity modulated particle radiotherapy in locally advanced lung cancer: a scenario-based uncertainty analysis compared to photon radiotherapy (IMRT). [PDF]

J Thorac Dis
Ming X, Sheng Y, Chen J, Wu K, Wang X, Mao J, Ma N.   +6 more
europepmc   +1 more source

Advancing Normal Tissue Complication Probability Modeling with Supervised Contrastive Learning for Predicting Osteoradionecrosis. [PDF]

Proc Symp Appl Comput
Anyimadu EA, Zhang X, Fuller CD, Marai GE, Canahuate G.   +4 more
europepmc   +1 more source

Post-Translational Modifications of NTCP: A Regulatory Nexus for Bile Acid Transport and HBV Entry. [PDF]

Biomedicines
Yu F, Zhu Y, Li N, Peng Q, Ye F, Luo Q, Xia J, Hu X.   +7 more
europepmc   +1 more source