Results 71 to 80 of about 16,210 (241)

Time is NTCP: Should we maximize patient throughput or perform online adaptation on proton therapy systems?

Radiotherapy and Oncology
BACKGROUND Compared to conventional radiotherapy (XT), proton therapy (PT) may improve normal tissue complication probabilities (NTCP). However, PT typically requires higher adaptation rates due to an increased sensitivity to anatomical changes ...
E. Borderias-Villarroel, A. Barragán Montero, E. Sterpin   +2 more
semanticscholar   +1 more source

Molecular insight into the bile acid transporter NTCP [PDF]

, 2020
Bile acids have besides their emulsification function in the intestine also a signalling role in many metabolic pathways. Bile acids circulate in the body via the enterohepatic circulation.
Appelman, M.D.
core  

Ntcp regions critical for HBV/WMHBV binding. [PDF]

, 2018
(A) PreS12-48 peptide sequences of human HBV, genotype D, and of woolly monkey HBV (WMHBV). The following domains are supposed to interact with NTCP/Ntcp: main binding domain (black, amino acids 9–15), accessory binding domains I (dark grey, amino acids ...
Simon F. Müller (5410238), Dieter Glebe (421759), Barbara Döring (411340), Joachim Geyer (411344), Alexander König (2526433)   +4 more
core   +1 more source

Upregulation of HBV transcription by sodium taurocholate cotransporting polypeptide at the postentry step is inhibited by the entry inhibitor Myrcludex B

Emerging Microbes and Infections, 2018
Sodium taurocholate cotransporting polypeptide (NTCP) is a functional receptor for hepatitis B virus (HBV) entry. However, little is known regarding whether NTCP is involved in regulating the postentry steps of the HBV life cycle.
Kaitao Zhao, Shuhui Liu, Yingshan Chen, Yongxuan Yao, Ming Zhou, Yifei Yuan, Yun Wang, Rongjuan Pei, Jizheng Chen, Xue Hu, Yuan Zhou, He Zhao, Mengji Lu, Chunchen Wu, Xinwen Chen   +14 more
doaj   +1 more source

Variable-RBE-induced NTCP predictions for various side-effects following proton therapy for brain tumors - Identification of high-risk patients and risk mitigation.

Radiotherapy and Oncology
BACKGROUND AND PURPOSE Disregarding the increase of relative biological effectiveness (RBE) may raise the risk of acute and late adverse events after proton beam therapy (PBT).
M. Palkowitsch, L. Kaufmann, F. Hennings, S. Menkel, C. Hahn, J. Bensberg, A. Lühr, A. Seidlitz, E. Troost, Mechthild Krause, S. Löck   +10 more
semanticscholar   +1 more source

Multivariate NTCP Model of Hypothyroidism After Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma

Frontiers in Oncology, 2021
Objective To evaluate the incidence of hypothyroidism in patients with nasopharyngeal carcinoma after intensity-modulated radiotherapy (IMRT), analyze its correlation with multiple influencing factors such as thyroid exposure dose, thyroid volume, and ...
G. Shen, Ying-lin Peng, Jian Li, Haijun Wu, Guang-shun Zhang, Chong Zhao, Xiaowu Deng   +6 more
semanticscholar   +1 more source

The introduction of video-enabled directly observed therapy (video-DOT) for patients with drug-resistant TB disease in Eswatini amid the COVID-19 pandemic – a retrospective cohort study

BMC Health Services Research
Background Video-enabled directly observed therapy (video-DOT) has been proposed as an additional option for treatment provision besides in-person DOT for patients with drug-resistant TB (DRTB) disease.
Bernhard Kerschberger, Michelle Daka, Bhekiwe Shongwe, Themba Dlamini, Siphiwe Ngwenya, Clara Danbakli, Bheki Mamba, Bongekile Nxumalo, Joyce Sibanda, Sisi Dube, Lindiwe Mdluli Dlamini, Edwin Mabhena, Esther Mukooza, Iona Crumley, Iza Ciglenecki, Debrah Vambe   +15 more
doaj   +1 more source

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na+‐Taurocholate Cotransporting Polypeptide

Hepatology Communications, 2018
Cholestasis‐induced accumulation of bile acids in the liver leads to farnesoid X receptor (FXR)‐mediated transcriptional down‐regulation of the bile acid importer Na+‐taurocholate cotransporting protein (NTCP) and to induction of endoplasmic reticulum ...
Marion J.D. Robin, Monique D. Appelman, Harmjan R. Vos, Robert M. van Es, James C. Paton, Adrienne W. Paton, Boudewijn Burgering, Peter Fickert, Jarom Heijmans, Stan F.J. van de Graaf   +9 more
doaj   +1 more source

Selective hepatitis B and D virus entry inhibitors from the group of pentacyclic lupane-type betulin-derived triterpenoids

Scientific Reports, 2020
Current treatment options against hepatitis B and D virus (HBV/HDV) infections have only limited curative effects. Identification of Na+/taurocholate co-transporting polypeptide (NTCP) as the high-affinity hepatic receptor for both viruses in 2012 ...
Michael Kirstgen, Kira Alessandra Alicia Theresa Lowjaga, Simon Franz Müller, Nora Goldmann, Felix Lehmann, Sami Alakurtti, Jari Yli-Kauhaluoma, Dieter Glebe, Joachim Geyer   +8 more
doaj   +1 more source