Results 71 to 80 of about 9,177 (185)

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, Volume 13, Issue 45, 13 August 2026.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Spinoculation Enhances HBV Infection in NTCP-Reconstituted Hepatocytes

PLOS ONE, 2015
Hepatitis B virus (HBV) infection and its sequelae remain a major public health burden, but both HBV basic research and the development of antiviral therapeutics have been hindered by the lack of an efficient in vitro infection system. Recently, sodium taurocholate cotransporting polypeptide (NTCP) has been identified as the HBV receptor.
Yan, Ran, Zhang, Yongmei, Cai, Dawei, Liu, Yuanjie, Cuconati, Andrea, Guo, Haitao   +5 more
openaire   +4 more sources

An integrated strategy of biological and physical constraints in biological optimization for cervical carcinoma

Radiation Oncology, 2017
Background For cervical carcinoma cases, this study aimed to evaluate the quality of intensity-modulated radiation therapy (IMRT) plans optimized by biological constraints. Furthermore, a new integrated strategy in biological planning module was proposed
Ziwei Feng, Cheng Tao, Jian Zhu, Jinhu Chen, Gang Yu, Shaohua Qin, Yong Yin, Dengwang Li   +7 more
doaj   +1 more source

A multidisciplinary experimental and methodological investigation of electron and proton minibeams in the framework of the INFN MIRO project

Medical Physics, Volume 53, Issue 8, August 2026.
Abstract Background The clinical translation of Minibeam RT (MBRT) has recently started thanks to the first human treatments recently performed. However, despite experimental evidence, the impact of the dose distribution parameters involved on the magnitude of the effect itself and the underlying radiobiological mechanisms are still only partially ...
Francesco Romano, Francesca Cella Zanacchi, Esther Ciarrocchi, Gaia Franciosini, Giuliana Milluzzo, Emanuele Scifoni, Anna Vignati, Said Ahmad, Silvia Arezzini, Andrea Attili, Marco Battestini, Jacopo Bernardini, Matteo Bettanin, Alessandra Bisio, Maria Giuseppina Bisogni, Igor Bodrenko, Giulio Bordieri, Valentina Bravatà, Alberto Burattini, Massimo Camarda, Francesco Paolo Cammarata, Simone Capaccioli, Lorenzo Castelli, Andrea Cavalieri, Mariagrazia Celentano, Enrica Chiadroni, Francesco Giuseppe Cordoni, Elena Corvaia, Mario Costa, Alessandro Curcio, Eleonora Da Pozzo, Martina De Felice, Francesca Del Debbio, Francesco D'Errico, Maria Cristina D'Oca, Beatrice D'Orsi, Umberto Deut, Elisabetta Durisi, Maria Evelina Fantacci, Stefano Farina, Giuseppe Felici, Arianna Ferro, Luca Ficcadenti, Antonino Formuso, Giusi Irma Forte, Simona Giordanengo, Alessia Giuliano, Lucia Giuliano, Luca Lanzanò, Stefania Linsalata, Simone Lossano, Margherita Maffei, Michela Marafini, Maurizio Marrale, Maurizio Massa, Luigi Masturzo, Enrico Mazzoni, Mauro Migliorati, Felix Mas Milian, Luigi Minafra, Andrea Moggi, Diango Montalvan Olivares, Marco Montefiori, Matteo Morrocchi, Andrea Mostacci, Franco Mostardi, Chinonso Okpuwe, Fabiola Paiar, Luigi Palumbo, Vincenzo Patera, Jake Harold Pensavalle, Gaia Pucci, Flaminia Quattrini, Alessandra Retico, Valeria Rosso, Giorgio Russo, Roberto Sacchi, Alessio Sarti, Silvia Scalisi, Camilla Scapicchio, Angelo Schiavi, Paolo Stochino, Enrica Strettoi, Francesco Tommasino, Valentina Tozzini, Giacomo Traini, Gabriele Trovato, Alice Usai, Francesco Urso, Fabio Di Martino   +89 more
wiley   +1 more source

Modelling dose and dose‐averaged linear energy transfer to predict high‐grade temporal lobe necrosis following skull‐base proton therapy

Medical Physics, Volume 53, Issue 8, August 2026.
Abstract Background In skull‐base proton therapy (PT), severe toxicity outcomes such as temporal lobe necrosis (TLN) may be associated with inadequate management of the actual radiobiological effectiveness (RBE) of proton beams. Combining dose‐averaged linear energy transfer (LETd) and dose may be crucial in treatment plan optimization and evaluation ...
Giulia Fontana, Elisa Fiorina, Sara Lillo, Lucia Pia Ciccone, Giulia Riva, Alessandro Vai, Mario Ciocca, Alberto Iannalfi, Silvia Molinelli, Ester Orlandi   +9 more
wiley   +1 more source

Down-regulation of cell membrane localized NTCP expression in proliferating hepatocytes prevents hepatitis B virus infection

Emerging Microbes and Infections, 2019
Hepatocyte proliferation could result in the loss of covalently closed circular DNA (cccDNA) and the emergence of cccDNA-cleared nascent hepatocytes, which appear refractory to hepatitis B virus (HBV) reinfection with unknown mechanism(s).
Ying Yan, Lena Allweiss, Danli Yang, Jingting Kang, Jianwen Wang, Xiangjun Qian, Ting Zhang, Hui Liu, Lu Wang, Shuhong Liu, Jianhua Sui, Xiangmei Chen, Maura Dandri, Jingmin Zhao, Fengmin Lu   +14 more
doaj   +1 more source

Feasibility of convection‐enhanced delivery of unlabeled 225Ac for glioblastoma: Transport, dosimetry, and clonogenic survival modeling

Medical Physics, Volume 53, Issue 8, August 2026.
Abstract Background Glioblastoma (GB) is an aggressive primary brain tumor with local recurrence rates exceeding 90% and a five‐year survival rate of approximately 5%. Standard treatments such as surgical resection, external beam radiotherapy (EBRT), and chemotherapy often leave residual tumor cells that are resistant to therapy.
Maram El Sabri, Leyla Moghaddasi, Puthenparampil Wilson, Frank Saran, Eva Bezak   +4 more
wiley   +1 more source

Radiobiology studies of gold nanoparticle‐enhanced radiosensitization in proton therapy

Medical Physics, Volume 53, Issue 8, August 2026.
Abstract Background Approximately 50%$\%$ of newly diagnosed cancer patients worldwide receive radiotherapy, most commonly with X‐rays. Proton therapy has emerged as a promising alternative, offering complementary advantages over conventional X‐rays due to its highly localized energy deposition at the Bragg peak, thereby reducing radiation exposure to ...
N. Fuster‐Martínez, D. H. Saucedo‐Cuberes, M. C. Jiménez‐Ramos, D. Esperante, J. M. Espino, J. Fuster, J. F. Belén‐Aguilar, L. González‐López, P. Huertas, S. Jimeno, I. Mingarro, D. Pascual, D. Suárez‐García, M. J. García‐Murria   +13 more
wiley   +1 more source

An ion treatment planning framework for inclusion of nanodosimetric ionization detail through cluster dose

Medical Physics, Volume 53, Issue 8, August 2026.
Abstract Background Nanodosimetry relates the cumulative or statistical moments of Ionization Detail (ID) with biological endpoints of relevance to cancer radiotherapy using charged particles. This association suggests to develop an additional physics‐detailed layer of modeling that may complement biological modeling and treatment planning.
Simona Facchiano, Ramon Ortiz, Remo Cristoforetti, Naoki D‐Kondo, Oliver Jäkel, Bruce Faddegon, Niklas Wahl   +6 more
wiley   +1 more source

The Radiobiological Impact of Dental Root Filling Material in Intensity-Modulated Radiation Therapy (IMRT) in Patients with Nasopharyngeal Carcinoma

مجله دانشکده پزشکی اصفهان, 2019
Background: Regarding the possibility of perturbation due to the presence of dental root filling material (DFM) in treatment planning of patients with nasopharyngeal cancer, we aimed to evaluate the impact of this material on tumor control probability ...
Pegah Saadatmand, Iraj Abedi, Alireza Amoohaidari, Ahmad Shanei   +3 more
doaj   +1 more source