Results 61 to 70 of about 17,063 (199)

Comparison of deep-learning multimodality data fusion strategies in mandibular osteoradionecrosis NTCP modelling using clinical variables and radiation dose distribution volumes

Physics in Medicine and Biology
Objective. Normal tissue complication probability (NTCP) modelling is rapidly embracing deep learning (DL) methods, acknowledging the importance of spatial dose information.
L. Humbert-Vidan, V. Patel, A. King, T. G. Urbano   +3 more
semanticscholar   +1 more source

The introduction of video-enabled directly observed therapy (video-DOT) for patients with drug-resistant TB disease in Eswatini amid the COVID-19 pandemic – a retrospective cohort study

BMC Health Services Research
Background Video-enabled directly observed therapy (video-DOT) has been proposed as an additional option for treatment provision besides in-person DOT for patients with drug-resistant TB (DRTB) disease.
Bernhard Kerschberger, Michelle Daka, Bhekiwe Shongwe, Themba Dlamini, Siphiwe Ngwenya, Clara Danbakli, Bheki Mamba, Bongekile Nxumalo, Joyce Sibanda, Sisi Dube, Lindiwe Mdluli Dlamini, Edwin Mabhena, Esther Mukooza, Iona Crumley, Iza Ciglenecki, Debrah Vambe   +15 more
doaj   +1 more source

Modeling Normal Tissue Complication Probability of Radiation-Induced Alopecia Following Intensity-Modulated Radiation Therapy in Glioblastoma Patients

Advanced Biomedical Research
Background: Glioblastoma multiforme (GBM) is an aggressive primary brain tumor requiring radiotherapy (RT), which often leads to radiation-induced alopecia (RIA), a distressing toxicity impacting quality of life.
Korosh Saber, Mahnaz Roayaei, Ahmad Shanei   +2 more
doaj   +1 more source

Variable-RBE-induced NTCP predictions for various side-effects following proton therapy for brain tumors - Identification of high-risk patients and risk mitigation.

Radiotherapy and Oncology
BACKGROUND AND PURPOSE Disregarding the increase of relative biological effectiveness (RBE) may raise the risk of acute and late adverse events after proton beam therapy (PBT).
M. Palkowitsch, L. Kaufmann, F. Hennings, S. Menkel, C. Hahn, J. Bensberg, A. Lühr, A. Seidlitz, E. Troost, Mechthild Krause, Steffen Löck   +10 more
semanticscholar   +1 more source

Integrated assessment of rifampicin‐mediated induction of transporters and drug‐metabolizing enzymes in a long‐term human liver tissue chip system

Clinical Pharmacology &Therapeutics, EarlyView.
Rifampicin is a prototypical clinical inducer used in drug–drug interaction (DDI) studies. However, the clinical relevance and predictability of rifampicin‐mediated hepatic transporter induction remain poorly defined. Conventional hepatocyte culture models fail to capture clinically relevant regulation of transporters and drug‐metabolizing enzymes ...
Mattie E. Hartauer, Raeanne M. Lanphier, Shivam Ohri, Jessica Snyder, Jacqueline B. Tiley, John K. Fallon, Henry Ho, Murat Cirit, Shiny Amala Priya Rajan, Kim L. R. Brouwer   +9 more
wiley   +1 more source

NTCP Structural Models

, 2020
This dataset contains homology models of the inward-open and outward-open conformation of the Na + /taurocholate cotransporting polypeptide (NTCP) as well as the the lowest-energy Rosetta-based models for variants at rheostat position ...
Karanicolas, J (via Mendeley Data)
core   +2 more sources

NTCP Modeling of Late Effects for Head and Neck Cancer: A Systematic Review

International Journal of Particle Therapy, 2021
Sonja Stieb, MD; Anna Lee, MD, MPH; Lisanne V. van Dijk, PhD; Steven Frank, MD; Clifton David Fuller, MD, PhD; Pierre Blanchard, MD, PhD Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Center for ...
Sonja Stieb, Anna Lee, L. V. van Dijk, S. Frank, C. Fuller, P. Blanchard   +5 more
semanticscholar   +1 more source

Estimated normal tissue complication probabilities (NTCP).

, 2016
NTCP values of xerostomia (upper) and dysphagia (lower) are shown per patient for IMRT (blue), 3-field minimax IMPT (gray) and 5-field minimax IMPT (green).
Lisanne V. van Dijk (2586112), Hans Paul van der Laan (89072), Roel J. H. M. Steenbakkers (552631), Aart A. van ‘t Veld (2586118), Erik W. Korevaar (2586115), Bennie ten Haken (348269), Johannes A. Langendijk (113480)   +6 more
core   +1 more source

Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na+‐Taurocholate Cotransporting Polypeptide

Hepatology Communications, 2018
Cholestasis‐induced accumulation of bile acids in the liver leads to farnesoid X receptor (FXR)‐mediated transcriptional down‐regulation of the bile acid importer Na+‐taurocholate cotransporting protein (NTCP) and to induction of endoplasmic reticulum ...
Marion J.D. Robin, Monique D. Appelman, Harmjan R. Vos, Robert M. van Es, James C. Paton, Adrienne W. Paton, Boudewijn Burgering, Peter Fickert, Jarom Heijmans, Stan F.J. van de Graaf   +9 more
doaj   +1 more source

Effect of N-linked glycosylation on NTCP protein expression.

, 2017
(A and B) HA-tagged NTCP was immunoprecipitated (IP) from lysates of HepG2 cells stably expressing NTCP-WT, NTCP-N5Q, NTCP-N11Q or NTCP-N5,11Q. IP samples were subjected to immunoblotting for NTCP (using anti-HA-hrp).
Stan F. J. van de Graaf (486942), Monique D. Appelman (3710119), Anindita Chakraborty (567793), Ulrike Protzer (199421), Jane A. McKeating (343022)   +4 more
core   +1 more source