Results 61 to 70 of about 16,210 (241)

The Lipid Raft Component Stomatin Interacts with the Na⁺ Taurocholate Cotransporting Polypeptide (NTCP) and Modulates Bile Salt Uptake

Cells, 2020
The sodium taurocholate cotransporting polypeptide (NTCP) is expressed at the basolateral membrane of hepatocytes, where it mediates the uptake of conjugated bile acids and forms the hepatocyte entry receptor for the hepatitis B and D virus.
Monique D. Appelman, Marion J.D. Robin, Esther W.M. Vogels, Christie Wolzak, Winnie G. Vos, Harmjan R. Vos, Robert M. Van Es, Boudewijn M.T. Burgering, Stan F.J. Van de Graaf   +8 more
doaj   +1 more source

Interleukin 6 inhibits HBV entry through NTCP down regulation. [PDF]

, 2015
International audienceHepatitis B virus (HBV) infection is a major public health problem. Recently, the human liver bile acid transporter Na+/taurocholate cotransporting polypeptide (NTCP) has been identified as an HBV specific receptor.
Bouezzedine, Fidaa, Fardel, Olivier, Gripon, Philippe   +2 more
core   +1 more source

Dosimetric and Biological Outcomes of Gamma Knife Radiosurgery and Volumetric Modulated Arc Therapy [PDF]

Iranian Journal of Medical Physics
Introduction: This research aimed to evaluate the radiation-induced secondary cancer risks in normal tissues following Gamma Knife Radiosurgery (GKR) compared with the Volumetric-Modulated Arc Therapy (VMAT).Material and Methods: Eleven patients with ...
Gad Elbaz, Ibrahim Hassan, Khairy Ereiba, Ehab Attalla   +3 more
doaj   +1 more source

Hepatitis B virus entry into HepG2‐NTCP cells requires clathrin‐mediated endocytosis

Cellular Microbiology, 2020
Hepatitis B virus (HBV) is a leading cause of cirrhosis and hepatocellular carcinoma worldwide, with 250 million individuals chronically infected. Many stages of the HBV infectious cycle have been elucidated, but the mechanisms of HBV entry remain poorly
Charline Herrscher, Florentin Pastor, Julien Burlaud‐Gaillard, Amélie Dumans, Florian Seigneuret, A. Moreau, R. Patient, S. Eymieux, H. de Rocquigny, C. Hourioux, P. Roingeard, Emmanuelle Blanchard   +11 more
semanticscholar   +1 more source

Concentration of Na+-taurocholate-cotransporting polypeptide expressed after in vitro-transcribed mRNA transfection determines susceptibility of hepatoma cells for hepatitis B virus

Scientific Reports, 2021
Infection of hepatocytes by hepatitis B virus (HBV) depends on surface expression of its receptor Na+-taurocholate-cotransporting polypeptide (NTCP), but sufficient NTCP expression is lacking in most cell lines.
Andreas Oswald, Anindita Chakraborty, Yi Ni, Jochen M. Wettengel, Stephan Urban, Ulrike Protzer   +5 more
doaj   +1 more source

Na⁺-Taurocholate Co-Transporting Polypeptide (NTCP) in Livers, Function, Expression Regulation, and Potential in Hepatitis B Treatment

Livers, 2021
Chronic hepatitis B virus (HBV) infection has become one of the leading causes of liver cirrhosis and hepatocellular carcinoma globally. The discovery of sodium taurocholate co-transporting polypeptide (NTCP), a solute carrier, as a key receptor for HBV ...
Xiaoyu Zhao, Waqas Iqbal, Pingnan Sun, Xiaoling Zhou   +3 more
doaj   +1 more source

Cytokine‐independent repression of rodent Ntcp in obstructive cholestasis† [PDF]

Hepatology, 2005
Cholestatic liver injury is associated not only with accumulation of bile acids but also with activation of proinflammatory cytokines. Common bile duct ligation (CBDL) induces sustained downregulation of the Na(+)/taurocholate cotransporter (Ntcp) in rodent liver.
Geier, A., Zollner, G., Dietrich, C.G., Wagner, M., Fickert, P., Denk, H., van Rooijen, N., Matern, S., Gartung, C., Trauner, M.   +9 more
openaire   +2 more sources

Interaktion des Hepatitis D Virus (HDV) mit seinem Rezeptor NTCP in einem in vitro Infektionssystem [PDF]

, 2021
Weltweit leiden mehrere Millionen Menschen unter chronischen Hepatitis B/D Virus-Infektionen, jedoch existieren zurzeit nur eingeschränkte Therapiemöglichkeiten.
Lowjaga, Kira Alessandra Alicia Theresa
core   +2 more sources

PCA-based respiratory motion modeling for individualized PTV margin optimization in NSCLC radiotherapy. [PDF]

J Appl Clin Med Phys
Abstract Background Respiratory motion remains a major challenge in radiotherapy for non‐small cell lung cancer (NSCLC), often requiring a balance between target coverage and normal tissue sparing. Introduction This study aimed to develop and validate a clinically implementable, individualized PTV margin strategy by integrating principal component ...
Quang HD, Thanh CN, Kieu THT, Van TC.
europepmc   +2 more sources

Hepatitis D Virus Entry Inhibitors Based on Repurposing Intestinal Bile Acid Reabsorption Inhibitors

Viruses, 2021
Identification of Na+/taurocholate co-transporting polypeptide (NTCP) as high-affinity hepatic entry receptor for the Hepatitis B and D viruses (HBV/HDV) opened the field for target-based development of cell-entry inhibitors. However, most of the HBV/HDV
Michael Kirstgen, Kira Alessandra Alicia Theresa Lowjaga, Simon Franz Müller, Nora Goldmann, Felix Lehmann, Dieter Glebe, Karl-Heinz Baringhaus, Joachim Geyer   +7 more
doaj   +1 more source