Results 41 to 50 of about 17,063 (199)

Evaluation of NTCP and Second Cancer Induction from Modulated Arc Therapy for High-Risk Prostate Carcinoma by COUPÔLE Software [PDF]

Iranian Journal of Medical Physics
Introduction: Assessing the toxicity and the risk of radiation-induced secondary cancer is crucial for optimizing treatment planning in prostate carcinoma patients with high risk undergoing Volumetric Modulated Arc Therapy (VMAT).
Assya Boughalia, Mohamed Fellah, Mohamed Zineddine El Ghribi, Kenza Benacer   +3 more
doaj   +1 more source

Specific Binding and Endocytosis of Liposomes to HEK293T Cells via Myrisoylated Pre-S1 Peptide Bound to Sodium Taurocholate Cotransporting Polypeptide

Vaccines, 2022
(1) Background: Sodium taurocholate cotransporting polypeptide (NTCP) functions as a key receptor for the hepatitis B virus (HBV) infection. Analyzing HBV and NTCP interaction is an important issue not only for basic research but also for the development
Shuji Hinuma, Kazuyo Fujita, Shun’ichi Kuroda   +2 more
doaj   +1 more source

An Immortalized Hepatocyte-Like Cell Line (imHC) Accommodated Complete Viral Lifecycle, Viral Persistence Form, cccDNA and Eventual Spreading of a Clinically-Isolated HBV

Viruses, 2019
More than 350 million people worldwide have been persistently infected with the hepatitis B virus (HBV). Chronic HBV infection could advance toward liver cirrhosis and hepatocellular carcinoma.
Khanit Sa-ngiamsuntorn, Piyanoot Thongsri, Yongyut Pewkliang, Adisak Wongkajornsilp, Pattida Kongsomboonchoke, Phichaya Suthivanich, Suparerk Borwornpinyo, Suradej Hongeng   +7 more
doaj   +1 more source

Na⁺-Taurocholate Co-Transporting Polypeptide (NTCP) in Livers, Function, Expression Regulation, and Potential in Hepatitis B Treatment

Livers, 2021
Chronic hepatitis B virus (HBV) infection has become one of the leading causes of liver cirrhosis and hepatocellular carcinoma globally. The discovery of sodium taurocholate co-transporting polypeptide (NTCP), a solute carrier, as a key receptor for HBV ...
Xiaoyu Zhao, Waqas Iqbal, Pingnan Sun, Xiaoling Zhou   +3 more
doaj   +1 more source

A novel semi auto-segmentation method for accurate dose and NTCP evaluation in adaptive head and neck radiotherapy.

Radiotherapy and Oncology, 2021
BACKGROUND AND PURPOSE Accurate segmentation of organs-at-risk (OARs) is crucial but tedious and time-consuming in adaptive radiotherapy (ART). The purpose of this work was to automate head and neck OAR-segmentation on repeat CT (rCT) by an optimal ...
Yong Gan, J. Langendijk, E. Oldehinkel, D. Scandurra, N. Sijtsema, Zhi-Xiong Lin, S. Both, C. Brouwer   +7 more
semanticscholar   +1 more source

Dosimetric Validation of Physical and Biological Indexes from the Dose-Volume Histogram for Evaluation of 3D-CRT and IMRT Techniques with VMAT Treatment Plan Techniques in Cervical Tumors from In-House Developed Software [PDF]

Iranian Journal of Medical Physics
Introduction:This study aims to investigate the Normal Tissue Complication Probability (NTCP) and Tumor Control Probability (TCP) of cervical cancer from Niemierko radiobiological model and compared with Lyman-Kutcher-Butcher (LKB) model’s effective ...
Sougoumarane Dashnamoorthy, Ebenezar Jeyasingh, VINDHYAVASINI PANDEY, Karthick Rajamanickam, Sachin S Kotur, Durga Prasad Sahoo   +5 more
doaj   +1 more source

The Lipid Raft Component Stomatin Interacts with the Na⁺ Taurocholate Cotransporting Polypeptide (NTCP) and Modulates Bile Salt Uptake

Cells, 2020
The sodium taurocholate cotransporting polypeptide (NTCP) is expressed at the basolateral membrane of hepatocytes, where it mediates the uptake of conjugated bile acids and forms the hepatocyte entry receptor for the hepatitis B and D virus.
Monique D. Appelman, Marion J.D. Robin, Esther W.M. Vogels, Christie Wolzak, Winnie G. Vos, Harmjan R. Vos, Robert M. Van Es, Boudewijn M.T. Burgering, Stan F.J. Van de Graaf   +8 more
doaj   +1 more source

Design of Dimeric Bile Acid Derivatives as Potent and Selective Human NTCP Inhibitors.

Journal of Medicinal Chemistry, 2021
Dimeric bile acid derivatives (DBADs) were developed and tested for their anti-HBV and anti-HDV activities as sodium taurocholate cotransporting polypeptide (NTCP) inhibitors.
Yang Liu, Lei Zhang, Huan Yan, Zhi-Qiang Wang, Guoliang Sun, Xiao Song, Zhong-Min Zhou, Bo Peng, Liwei Yan, Qingcui Wu, Wen-Hui Li, X. Qi   +11 more
semanticscholar   +1 more source

Dosimetric and Biological Outcomes of Gamma Knife Radiosurgery and Volumetric Modulated Arc Therapy [PDF]

Iranian Journal of Medical Physics
Introduction: This research aimed to evaluate the radiation-induced secondary cancer risks in normal tissues following Gamma Knife Radiosurgery (GKR) compared with the Volumetric-Modulated Arc Therapy (VMAT).Material and Methods: Eleven patients with ...
Gad Elbaz, Ibrahim Hassan, Khairy Ereiba, Ehab Attalla   +3 more
doaj   +1 more source

Concentration of Na+-taurocholate-cotransporting polypeptide expressed after in vitro-transcribed mRNA transfection determines susceptibility of hepatoma cells for hepatitis B virus

Scientific Reports, 2021
Infection of hepatocytes by hepatitis B virus (HBV) depends on surface expression of its receptor Na+-taurocholate-cotransporting polypeptide (NTCP), but sufficient NTCP expression is lacking in most cell lines.
Andreas Oswald, Anindita Chakraborty, Yi Ni, Jochen M. Wettengel, Stephan Urban, Ulrike Protzer   +5 more
doaj   +1 more source