Results 31 to 40 of about 16,210 (241)

Proton beam therapy in paediatric cancer: Anticipating the opening of the Australian Bragg Centre for Proton Therapy and Research

Journal of Medical Imaging and Radiation Oncology, EarlyView., 2023
Summary Proton Beam Therapy (PBT) has the potential to improve paediatric cancer care by reducing radiation exposure and thus long‐term toxicities. Ethical concerns and debates surrounding the treatment, such as eligibility and accessibility, are ongoing in Australia. The Australian Bragg Centre for Proton Therapy and Research (ABCPTR) (named after Sir
Jeremy Khong, Hui Tee, Peter Gorayski, Hien Le, Michael Penniment, Sophie Jessop, Jordan Hansford, Melanie Penfold, Julia Green, Kelly Skelton, Frank Saran   +10 more
wiley   +1 more source

Regulation of the HBV Entry Receptor NTCP and its Potential in Hepatitis B Treatment

Frontiers in Molecular Biosciences, 2022
Hepatitis B virus (HBV) is a globally prevalent human DNA virus responsible for more than 250 million cases of chronic liver infection, a condition that can lead to liver inflammation, cirrhosis, and hepatocellular carcinoma.
Yan Li, Jun Zhou, Tianliang Li
semanticscholar   +1 more source

The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro

PLoS Pathogens, 2022
Intracellular transport via microtubule-based dynein and kinesin family motors plays a key role in viral reproduction and transmission. We show here that Kinesin Family Member 4 (KIF4) plays an important role in HBV/HDV infection.
Sameh A. Gad, M. Sugiyama, M. Tsuge, K. Wakae, Kento Fukano, M. Oshima, C. Sureau, N. Watanabe, Takanobu Kato, Asako Murayama, Yingfang Li, I. Shoji, K. Shimotohno, K. Chayama, M. Muramatsu, T. Wakita, T. Nozaki, Hussein H. Aly   +17 more
semanticscholar   +1 more source

Establishment of a Monoclonal Antibody against Human NTCP That Blocks Hepatitis B Virus Infection

Journal of Virology, 2022
A number of entry inhibitors are being developed to enhance the treatment of HBV patients with oral nucleoside/nucleotide analogues (NA). To amplify the effectiveness of NA therapy, several efforts have been made to develop therapeutic MAbs with ...
T. Takemori, Akiko Sugimoto-Ishige, H. Nishitsuji, Y. Futamura, M. Harada, T. Kimura-Someya, Takehisa Matsumoto, T. Honma, Miho Tanaka, M. Yaguchi, K. Isono, H. Koseki, H. Osada, D. Miki, T. Saito, Takashi Tanaka, Takehiro Fukami, Toshio Goto, M. Shirouzu, K. Shimotohno, K. Chayama   +20 more
semanticscholar   +1 more source

Multitasking Na+/Taurocholate Cotransporting Polypeptide (NTCP) as a Drug Target for HBV Infection: From Protein Engineering to Drug Discovery

Biomedicines, 2022
Hepatitis B virus (HBV) infections are among the major public health concerns worldwide with more than 250 million of chronically ill individuals. Many of them are additionally infected with the Hepatitis D virus, a satellite virus to HBV.
Dariusz Zakrzewicz, J. Geyer
semanticscholar   +1 more source

Normal Tissue Complication Probability (NTCP) Prediction Model for Osteoradionecrosis of the Mandible in Patients With Head and Neck Cancer After Radiation Therapy: Large-Scale Observational Cohort

medRxiv, 2021
Background and purpose. Osteoradionecrosis (ORN) of the mandible represents a severe, debilitating complication of radiation therapy (RT) for head and neck cancer (HNC).
L. V. van Dijk, A. Abusaif, Jillian M Rigert, Mohamed A. Naser, K. Hutcheson, S. Lai, C. Fuller, A. Mohamed   +7 more
semanticscholar   +1 more source

NTCP Structural Models [PDF]

, 2020
This dataset contains homology models of the inward-open and outward-open conformation of the Na + /taurocholate cotransporting polypeptide (NTCP) as well as the the lowest-energy Rosetta-based models for variants at rheostat position ...
Karanicolas, J (via Mendeley Data)
core   +3 more sources

Molecular regulation of the hepatic bile acid uptake transporter and HBV entry receptor NTCP.

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2021
Transporters expressed by hepatocytes and enterocytes play a critical role in maintaining the enterohepatic circulation of bile acids. The sodium taurocholate cotransporting polypeptide (NTCP), exclusively expressed at the basolateral side of hepatocytes,
Monique D. Appelman, J. Wettengel, U. Protzer, R. O. Oude Elferink, S. V. D. van de Graaf   +4 more
semanticscholar   +1 more source

Free Cholesterol Affects the Function and Localization of Human Na+/Taurocholate Cotransporting Polypeptide (NTCP) and Organic Cation Transporter 1 (OCT1)

International Journal of Molecular Sciences, 2022
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are associated with obesity. They are accompanied by increased levels of free cholesterol in the liver. Most free cholesterol resides within the plasma membrane.
Jessica Y. Idowu, B. Hagenbuch
semanticscholar   +1 more source

Chemical compounds targeting NTCP-mediated HBV entry. [PDF]

, 2022
Chemical compounds targeting NTCP-mediated HBV entry.
Hussein H. Aly (12269985), Masataka Tsuge (128622), Noriyuki Watanabe (434683), Kazuaki Chayama (128675), Masamichi Muramatsu (407159), Camille Sureau (4029170), Kosho Wakae (12269982), Takaji Wakita (109321), Masaya Sugiyama (135004), Kento Fukano (6181988), Yingfang Li (9637076), Mizuki Oshima (6181991), Ikuo Shoji (127861), Kunitada Shimotohno (142262), Sameh A. Gad (12269979), Asako Murayama (109309), Tomoyoshi Nozaki (131314), Takanobu Kato (109325)   +17 more
core   +1 more source