Results 31 to 40 of about 9,177 (185)

Specific Binding and Endocytosis of Liposomes to HEK293T Cells via Myrisoylated Pre-S1 Peptide Bound to Sodium Taurocholate Cotransporting Polypeptide

Vaccines, 2022
(1) Background: Sodium taurocholate cotransporting polypeptide (NTCP) functions as a key receptor for the hepatitis B virus (HBV) infection. Analyzing HBV and NTCP interaction is an important issue not only for basic research but also for the development
Shuji Hinuma, Kazuyo Fujita, Shun’ichi Kuroda   +2 more
doaj   +1 more source

An Immortalized Hepatocyte-Like Cell Line (imHC) Accommodated Complete Viral Lifecycle, Viral Persistence Form, cccDNA and Eventual Spreading of a Clinically-Isolated HBV

Viruses, 2019
More than 350 million people worldwide have been persistently infected with the hepatitis B virus (HBV). Chronic HBV infection could advance toward liver cirrhosis and hepatocellular carcinoma.
Khanit Sa-ngiamsuntorn, Piyanoot Thongsri, Yongyut Pewkliang, Adisak Wongkajornsilp, Pattida Kongsomboonchoke, Phichaya Suthivanich, Suparerk Borwornpinyo, Suradej Hongeng   +7 more
doaj   +1 more source

Perfluoroalkyl Carboxylic Acids Interact with the Human Bile Acid Transporter NTCP

Livers, 2021
Na+/taurocholate cotransporting polypeptide (NTCP) is important for the enterohepatic circulation of bile acids, which has been suggested to contribute to the long serum elimination half-lives of perfluoroalkyl substances in humans.
Melissa J. Ruggiero, Haley Miller, Jessica Y. Idowu, Jeremiah D. Zitzow, Shu-Ching Chang, Bruno Hagenbuch   +5 more
doaj   +1 more source

Dosimetric Validation of Physical and Biological Indexes from the Dose-Volume Histogram for Evaluation of 3D-CRT and IMRT Techniques with VMAT Treatment Plan Techniques in Cervical Tumors from In-House Developed Software [PDF]

Iranian Journal of Medical Physics
Introduction:This study aims to investigate the Normal Tissue Complication Probability (NTCP) and Tumor Control Probability (TCP) of cervical cancer from Niemierko radiobiological model and compared with Lyman-Kutcher-Butcher (LKB) model’s effective ...
Sougoumarane Dashnamoorthy, Ebenezar Jeyasingh, VINDHYAVASINI PANDEY, Karthick Rajamanickam, Sachin S Kotur, Durga Prasad Sahoo   +5 more
doaj   +1 more source

The Lipid Raft Component Stomatin Interacts with the Na⁺ Taurocholate Cotransporting Polypeptide (NTCP) and Modulates Bile Salt Uptake

Cells, 2020
The sodium taurocholate cotransporting polypeptide (NTCP) is expressed at the basolateral membrane of hepatocytes, where it mediates the uptake of conjugated bile acids and forms the hepatocyte entry receptor for the hepatitis B and D virus.
Monique D. Appelman, Marion J.D. Robin, Esther W.M. Vogels, Christie Wolzak, Winnie G. Vos, Harmjan R. Vos, Robert M. Van Es, Boudewijn M.T. Burgering, Stan F.J. Van de Graaf   +8 more
doaj   +1 more source

Na⁺-Taurocholate Co-Transporting Polypeptide (NTCP) in Livers, Function, Expression Regulation, and Potential in Hepatitis B Treatment

Livers, 2021
Chronic hepatitis B virus (HBV) infection has become one of the leading causes of liver cirrhosis and hepatocellular carcinoma globally. The discovery of sodium taurocholate co-transporting polypeptide (NTCP), a solute carrier, as a key receptor for HBV ...
Xiaoyu Zhao, Waqas Iqbal, Pingnan Sun, Xiaoling Zhou   +3 more
doaj   +1 more source

Dosimetric and Biological Outcomes of Gamma Knife Radiosurgery and Volumetric Modulated Arc Therapy [PDF]

Iranian Journal of Medical Physics
Introduction: This research aimed to evaluate the radiation-induced secondary cancer risks in normal tissues following Gamma Knife Radiosurgery (GKR) compared with the Volumetric-Modulated Arc Therapy (VMAT).Material and Methods: Eleven patients with ...
Gad Elbaz, Ibrahim Hassan, Khairy Ereiba, Ehab Attalla   +3 more
doaj   +1 more source

Concentration of Na+-taurocholate-cotransporting polypeptide expressed after in vitro-transcribed mRNA transfection determines susceptibility of hepatoma cells for hepatitis B virus

Scientific Reports, 2021
Infection of hepatocytes by hepatitis B virus (HBV) depends on surface expression of its receptor Na+-taurocholate-cotransporting polypeptide (NTCP), but sufficient NTCP expression is lacking in most cell lines.
Andreas Oswald, Anindita Chakraborty, Yi Ni, Jochen M. Wettengel, Stephan Urban, Ulrike Protzer   +5 more
doaj   +1 more source

HepG2-NTCP Subclones Exhibiting High Susceptibility to Hepatitis B Virus Infection

Viruses, 2022
HepG2 cells reconstituted with Hepatitis B virus (HBV) entry receptor sodium taurocholate co-transporting polypeptide (NTCP) are widely used as a convenient in vitro cell culture infection model for HBV replication studies.
Muhammad Atif Zahoor, Adrian Kuipery, Alexander I. Mosa, Adam J. Gehring, Jordan J. Feld   +4 more
doaj   +1 more source

Cytokine‐independent repression of rodent Ntcp in obstructive cholestasis† [PDF]

Hepatology, 2005
Cholestatic liver injury is associated not only with accumulation of bile acids but also with activation of proinflammatory cytokines. Common bile duct ligation (CBDL) induces sustained downregulation of the Na(+)/taurocholate cotransporter (Ntcp) in rodent liver.
Geier, A., Zollner, G., Dietrich, C.G., Wagner, M., Fickert, P., Denk, H., van Rooijen, N., Matern, S., Gartung, C., Trauner, M.   +9 more
openaire   +2 more sources