Results 31 to 40 of about 17,063 (199)

Elevated NTCP expression by an iPSC-derived human hepatocyte maintenance medium enhances HBV infection in NTCP-reconstituted HepG2 cells

Cell & Bioscience, 2021
Background The sodium taurocholate cotransporting polypeptide (NTCP) is a functional receptor for hepatitis B virus (HBV). NTCP-reconstituted human hepatoma cells support HBV infection, but the infection is suboptimal and no apparent HBV spread has been ...
Xinlei Li, Zhaohui Xu, Bidisha Mitra, Minghang Wang, Haitao Guo, Zongdi Feng   +5 more
doaj   +1 more source

Establishment of a Monoclonal Antibody against Human NTCP That Blocks Hepatitis B Virus Infection

Journal of Virology, 2022
A number of entry inhibitors are being developed to enhance the treatment of HBV patients with oral nucleoside/nucleotide analogues (NA). To amplify the effectiveness of NA therapy, several efforts have been made to develop therapeutic MAbs with ...
T. Takemori, Akiko Sugimoto-Ishige, H. Nishitsuji, Y. Futamura, M. Harada, T. Kimura-Someya, Takehisa Matsumoto, T. Honma, Miho Takana, M. Yaguchi, K. Isono, H. Koseki, H. Osada, D. Miki, T. Saito, Takashi Tanaka, Takehiro Fukami, Toshio Goto, M. Shirouzu, K. Shimotohno, K. Chayama   +20 more
semanticscholar   +1 more source

Hepatic bile salt uptake:The role of NTCP revisited [PDF]

, 2019
NTCP is een cruciale transporter van geconjugeerde galzouten binnen de enterohepatische kringloop van galzouten. Wij hebben diens functioneren onderzocht in een NTCP-knockout muis en met een specifieke farmacologische NTCP-remmer myrcludex B.
Slijepčević, D.
core   +8 more sources

Molecular regulation of the hepatic bile acid uptake transporter and HBV entry receptor NTCP.

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2021
Transporters expressed by hepatocytes and enterocytes play a critical role in maintaining the enterohepatic circulation of bile acids. The sodium taurocholate cotransporting polypeptide (NTCP), exclusively expressed at the basolateral side of hepatocytes,
Monique D. Appelman, J. Wettengel, U. Protzer, R. O. Oude Elferink, S. V. D. van de Graaf   +4 more
semanticscholar   +1 more source

Free Cholesterol Affects the Function and Localization of Human Na+/Taurocholate Cotransporting Polypeptide (NTCP) and Organic Cation Transporter 1 (OCT1)

International Journal of Molecular Sciences, 2022
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are associated with obesity. They are accompanied by increased levels of free cholesterol in the liver. Most free cholesterol resides within the plasma membrane.
Jessica Y. Idowu, B. Hagenbuch
semanticscholar   +1 more source

N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection.

PLoS ONE, 2017
The sodium/bile acid cotransporter NTCP was recently identified as a receptor for hepatitis B virus (HBV). NTCP is glycosylated and the role of glycans in protein trafficking or viral receptor activity is not known.
Monique D Appelman, Anindita Chakraborty, Ulrike Protzer, Jane A McKeating, Stan F J van de Graaf   +4 more
doaj   +1 more source

Curcumin inhibited hepatitis B viral entry through NTCP binding

Scientific Reports, 2021
Hepatitis B virus (HBV) has been implicated in hepatitis and hepatocellular carcinoma. Current agents (nucleos(t)ide analogs and interferons) could only attenuate HBV infection. A combination of agents targeting different stages of viral life cycle (e.g.,
Piyanoot Thongsri, Yongyut Pewkliang, S. Borwornpinyo, A. Wongkajornsilp, S. Hongeng, Khanit Sa-ngiamsuntorn   +5 more
semanticscholar   +1 more source

Substrate Specificities and Inhibition Pattern of the Solute Carrier Family 10 Members NTCP, ASBT and SOAT

Frontiers in Molecular Biosciences, 2021
Three carriers of the solute carrier family SLC10 have been functionally characterized so far. Na+/taurocholate cotransporting polypeptide NTCP is a hepatic bile acid transporter and the cellular entry receptor for the hepatitis B and D viruses.
G. Grosser, S. F. Müller, Michael Kirstgen, Barbara Döring, J. Geyer   +4 more
semanticscholar   +1 more source

The Use of Normal Tissue Complication Probability (NTCP) Models in the Clinic

International Journal of Radiation Oncology, Biology, Physics, 2010
The QUANTEC (quantitative analysis of normal tissue effects in the clinic) review summarizes the currently-available three dimensional dose/volume/outcome data to update and refine the normal tissue dose/volume tolerance guidelines provided by the ...
L. Marks, E. Yorke, A. Jackson, R. Ten Haken, L. Constine, A. Eisbruch, S. Bentzen, J. Nam, J. Deasy   +8 more
semanticscholar   +1 more source

NTCP deficiency in mice protects against obesity and hepatosteatosis [PDF]

, 2019
Bile acids play a major role in the regulation of lipid and energy metabolism. Here we propose the hepatic bile acid uptake transporter Na+ taurocholate cotransporting polypeptide (NTCP) as a target to prolong postprandial bile acid elevations in plasma.
Donkers, Joanne M., Slijepcevic, Davor, Schoonjans, Kristina, Haazen, Lizette, van de Graaf, Stan F. J., Elferink, Ronald P. J. Oude, Roscam Abbing, Reinout L. P., Kooijman, Sander, de Waart, Dirk R., Oude Elferink, Ronald P. J., Rensen, Patrick C. N., Kunst, Roni F., Levels, Johannes H. M., Abbing, Reinout L. P. Roscam   +13 more
core   +2 more sources