Results 11 to 20 of about 17,063 (199)

Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP [PDF]

Nature Communications
Cellular entry of the hepatitis B and D viruses (HBV/HDV) requires binding of the viral surface polypeptide preS1 to the hepatobiliary transporter Na+-taurocholate co-transporting polypeptide (NTCP).
Hongtao Liu, Dariusz Zakrzewicz, Kamil Nosol, Rossitza N. Irobalieva, Somnath Mukherjee, Rose Bang-Sørensen, Nora Goldmann, Sebastian Kunz, Lorenzo Rossi, Anthony A. Kossiakoff, Stephan Urban, Dieter Glebe, Joachim Geyer, Kaspar P. Locher   +13 more
doaj   +3 more sources

NTCP ubiquitination enables HBV infection

JHEP Reports
Background & Aims: The sodium taurocholate cotransporting polypeptide (NTCP), the main hepatic uptake transporter of bile salts, is the docking receptor required for the HBV/HDV entry.
Monique D. Appelman, Thuc-Anh Nguyen, Andreas Oswald, Aaron Lucko, Coen C. Paulusma, Ulrike Protzer, Stan F.J. van de Graaf   +6 more
doaj   +2 more sources

Mutational Analysis of the GXXXG/A Motifs in the Human Na+/Taurocholate Co-Transporting Polypeptide NTCP on Its Bile Acid Transport Function and Hepatitis B/D Virus Receptor Function

Frontiers in Molecular Biosciences, 2021
Homodimerization is essential for plasma membrane sorting of the liver bile acid transporter NTCP and its function as Hepatitis B/D Virus (HBV/HDV) receptor. However, the protein domains involved in NTCP dimerization are unknown. NTCP bears two potential
Massimo Palatini, Simon Franz Müller, Kira Alessandra Alicia Theresa Lowjaga, Saskia Noppes, Jörg Alber, Felix Lehmann, Nora Goldmann, Dieter Glebe, Joachim Geyer   +8 more
doaj   +2 more sources

ZO-2 determines cell membrane localization of receptor NTCP and supports hepatitis B virus infection [PDF]

mBio
Hepatitis B virus (HBV) infects hepatocytes by using sodium taurocholate cotransporting polypeptide (NTCP) as a receptor. NTCP can render non-permissive hepatocyte cell lines such as HepG2 permissive to HBV infection.
Hironori Nishitsuji, Saori Yoshimura, Daijiro Konno, Taro Tachibana, Masaya Sugiyama, Manabu Yamasaki, Masashi Mizokami, Takayuki Murata, Kunitada Shimotohno   +8 more
doaj   +2 more sources

Genetically edited hepatic cells expressing the NTCP-S267F variant are resistant to hepatitis B virus infection

Molecular Therapy: Methods & Clinical Development, 2021
The sodium-dependent taurocholate co-transporting polypeptide (NTCP)-S267F variant is known to be associated with a reduced risk of hepatitis B virus (HBV) infection and disease progression.
Takuro Uchida, Seung Bum Park, Tadashi Inuzuka, Min Zhang, Joselyn N. Allen, Kazuaki Chayama, T. Jake Liang   +6 more
doaj   +2 more sources

Dosimetric and radiobiological evaluations as well as technical aspects of left breast treatment employing DIBH with SGRT in radiotherapy with IMRT step and shoot, IMRT Dynamic MLC and VMAT. [PDF]

J Appl Clin Med Phys
Abstract Background Treatment of the left breast using deep inspiration breath hold (DIBH), combined with surface guided radiotherapy (SGRT), has emerged as the standard for reducing the dose to the heart, the left anterior descending coronary artery (LAD), and the ipsilateral lung.
Rolland J, Payan S, Fau P, Mailleux H, Tallet A.   +4 more
europepmc   +2 more sources

A mechanistic‐based normal tissue complication probability (NTCP) prediction through a microdosimetry‐based multiscale radiation biophysical model (MS‐GSM2) [PDF]

Precis Radiat Oncol
Precision Radiation Oncology, EarlyView.
Battestini M, Missiaggia M, Bordieri G, Morand J, Scifoni E, Cordoni F.   +5 more
europepmc   +2 more sources

Prognostic Value of NTCP p.Ser267Phe Variant in Patients with Chronic Hepatitis B

Namık Kemal Tıp Dergisi
Aim: In this study, the aim is to detect polymorphisms in the gene encoding the sodium taurocholate cotransporting polypeptide (NTCP), the functional receptor for hepatitis B virus (HBV) and hepatitis D virus.
Bülent ÇAKAL, Alp ATASOY, Mehveş PODA, Bilger ÇAVUŞ, Mesut BULAKÇI, Mine GÜLLÜOĞLU, Filiz AKYÜZ   +6 more
doaj   +2 more sources

Comparison of Estimated Late Toxicities between IMPT and IMRT Based on Multivariable NTCP Models for High-Risk Prostate Cancers Treated with Pelvic Nodal Radiation [PDF]

International Journal of Particle Therapy, 2022
Purpose: To compare the late gastrointestinal (GI) and genitourinary toxicities (GU) estimated using multivariable normal tissue complication probability (NTCP) models, between pencil-beam scanning proton beam therapy (PBT) and helical tomotherapy (HT ...
Srinivas Chilukuri, MD, Sham Sundar, MD, Kartikeswar Patro, MSc, Mayur Sawant, MSc, Rangasamy Sivaraman, MSc, Manikandan Arjunan, PhD, Pankaj Kumar Panda, MSc, Dayananda Sharma, PhD, Rakesh Jalali, MD   +8 more
doaj   +1 more source

Monte Carlo-based Volumetric Arc Radiation Therapy vs. Helical Tomotherapy in Terms of Tumor Control Probability and Normal Tissue Complication Probability for Endometrial Cancers

Cam & Sakura Medical Journal, 2021
Objective: This study aimed to compare the effectiveness and to plan parameters of the Monte Carlo (MC)-based volumetric arc radiation therapy (VMAT) plan, which was devised using the equivalent uniform dose concept for endometrial cancers, to the dose ...
Sümeyra Can, İlknur Harmankaya, Özge Atilla, Ayben Yentek Balkanay, Didem Karaçetin   +4 more
doaj   +1 more source