Results 11 to 20 of about 16,210 (241)

IFITM3 Interacts with the HBV/HDV Receptor NTCP and Modulates Virus Entry and Infection [PDF]

Viruses, 2022
The Na+/taurocholate co-transporting polypeptide (NTCP, gene symbol SLC10A1) is both a physiological bile acid transporter and the high-affinity hepatic receptor for the hepatitis B and D viruses (HBV/HDV).
Massimo Palatini, Simon Franz Müller, Michael Kirstgen, Silke Leiting, Felix Lehmann, Lena Soppa, Nora Goldmann, Christin Müller, Kira Alessandra Alicia Theresa Lowjaga, Jörg Alber, Giuliano Ciarimboli, John Ziebuhr, Dieter Glebe, Joachim Geyer   +13 more
doaj   +3 more sources

NTCP Deficiency Affects the Levels of Circulating Bile Acids and Induces Osteoporosis [PDF]

Frontiers in Endocrinology, 2022
BackgroundThe p.Ser267Phe mutation in the SLC10A1 gene can cause NTCP deficiency. However, the full clinical presentation of p.Ser267Phe homozygous individuals and its long-term consequences remain unclear.
Fangji Yang, Wenxiong Xu, Lina Wu, Luo Yang, Shu Zhu, Lu Wang, Wenbin Wu, Yuzhen Zhang, Yutian Chong, Yutian Chong, Liang Peng, Liang Peng   +11 more
doaj   +4 more sources

Perfluoroalkyl Carboxylic Acids Interact with the Human Bile Acid Transporter NTCP [PDF]

Livers, 2021
Na+/taurocholate cotransporting polypeptide (NTCP) is important for the enterohepatic circulation of bile acids, which has been suggested to contribute to the long serum elimination half-lives of perfluoroalkyl substances in humans.
Melissa J. Ruggiero, Haley Miller, Jessica Y. Idowu, Jeremiah D. Zitzow, Shu-Ching Chang, Bruno Hagenbuch   +5 more
doaj   +3 more sources

Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP [PDF]

Nature Communications
Cellular entry of the hepatitis B and D viruses (HBV/HDV) requires binding of the viral surface polypeptide preS1 to the hepatobiliary transporter Na+-taurocholate co-transporting polypeptide (NTCP).
Hongtao Liu, Dariusz Zakrzewicz, Kamil Nosol, Rossitza N. Irobalieva, Somnath Mukherjee, Rose Bang-Sørensen, Nora Goldmann, Sebastian Kunz, Lorenzo Rossi, Anthony A. Kossiakoff, Stephan Urban, Dieter Glebe, Joachim Geyer, Kaspar P. Locher   +13 more
doaj   +4 more sources

Tyrosine 146 of the Human Na⁺/Taurocholate Cotransporting Polypeptide (NTCP) Is Essential for Its Hepatitis B Virus (HBV) Receptor Function and HBV Entry into Hepatocytes

Viruses, 2022
Na+/taurocholate cotransporting polypeptide (NTCP, gene symbol SLC10A1) is a hepatic bile acid uptake carrier participating in the enterohepatic circulation of bile acids. Apart from its transporter function, NTCP acts as the high-affinity liver-specific
Dariusz Zakrzewicz, Regina Leidolf, Sebastian Kunz, Simon Franz Müller, Anita Neubauer, Silke Leiting, Nora Goldmann, Felix Lehmann, Dieter Glebe, Joachim Geyer   +9 more
doaj   +2 more sources

Mutational Analysis of the GXXXG/A Motifs in the Human Na+/Taurocholate Co-Transporting Polypeptide NTCP on Its Bile Acid Transport Function and Hepatitis B/D Virus Receptor Function

Frontiers in Molecular Biosciences, 2021
Homodimerization is essential for plasma membrane sorting of the liver bile acid transporter NTCP and its function as Hepatitis B/D Virus (HBV/HDV) receptor. However, the protein domains involved in NTCP dimerization are unknown. NTCP bears two potential
Massimo Palatini, Simon Franz Müller, Kira Alessandra Alicia Theresa Lowjaga, Saskia Noppes, Jörg Alber, Felix Lehmann, Nora Goldmann, Dieter Glebe, Joachim Geyer   +8 more
doaj   +2 more sources

NTCP deficiency in mice protects against obesity and hepatosteatosis [PDF]

JCI Insight, 2019
Bile acids play a major role in the regulation of lipid and energy metabolism. Here we propose the hepatic bile acid uptake transporter Na + taurocholate cotransporting polypeptide (NTCP) as a target to prolong postprandial bile acid elevations in plasma.
Joanne M. Donkers, Sander Kooijman, Davor Slijepcevic, Roni F. Kunst, Reinout L.P. Roscam Abbing, Lizette Haazen, Dirk R. de Waart, Johannes H.M. Levels, Kristina Schoonjans, Patrick C.N. Rensen, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf   +11 more
core   +7 more sources

Genetically edited hepatic cells expressing the NTCP-S267F variant are resistant to hepatitis B virus infection

Molecular Therapy: Methods & Clinical Development, 2021
The sodium-dependent taurocholate co-transporting polypeptide (NTCP)-S267F variant is known to be associated with a reduced risk of hepatitis B virus (HBV) infection and disease progression.
Takuro Uchida, Seung Bum Park, Tadashi Inuzuka, Min Zhang, Joselyn N. Allen, Kazuaki Chayama, T. Jake Liang   +6 more
doaj   +2 more sources

Normal tissue complication probability (NTCP) models for modern radiation therapy. [PDF]

Seminars in Oncology, 2019
Mathematical models of normal tissue complication probability (NTCP) able to robustly predict radiation-induced morbidities (RIM) play an essential role in the identification of a personalized optimal plan, and represent the key to maximizing the ...
G. Palma, S. Monti, M. Conson, R. Pacelli, L. Cella   +4 more
semanticscholar   +2 more sources

Prognostic Value of NTCP p.Ser267Phe Variant in Patients with Chronic Hepatitis B [PDF]

Namık Kemal Tıp Dergisi
Aim: In this study, the aim is to detect polymorphisms in the gene encoding the sodium taurocholate cotransporting polypeptide (NTCP), the functional receptor for hepatitis B virus (HBV) and hepatitis D virus.
Bülent ÇAKAL, Alp ATASOY, Mehveş PODA, Bilger ÇAVUŞ, Mesut BULAKÇI, Mine GÜLLÜOĞLU, Filiz AKYÜZ   +6 more
doaj   +2 more sources