Results 11 to 20 of about 9,177 (185)

Mechanistic insights into the inhibition of NTCP by myrcludex B [PDF]

JHEP Reports, 2019
Background & aims: The sodium taurocholate co-transporting polypeptide (NTCP) is the entry receptor for the hepatitis B and delta virus (HBV/HDV) and the main hepatic uptake transporter of conjugated bile acids. Myrcludex B, a synthetic peptide mimicking
Stan Van De Graaf, Joanne Donkers
exaly   +6 more sources

The Culprit Behind HBV-Infected Hepatocytes: NTCP

Drug Design, Development and Therapy
Shenghao Li,1,2,* Liyuan Hao,1,2,* Jiali Deng,1,2 Junli Zhang,3 Fei Yu,1,2 Fanghang Ye,1,2 Na Li,1,2 Xiaoyu Hu2 1School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, People’s Republic of ...
Li S, Hao L, Deng J, Zhang J, Yu F, Ye F, Li N, Hu X   +7 more
exaly   +5 more sources

Targeting NTCP for liver disease treatment: A promising strategy

Journal of Pharmaceutical Analysis
The sodium taurocholate co-transporting polypeptide (NTCP), a bile acids transporter, has been identified as a new therapeutic target for the treatment of liver disease.
Dongke Yu, Xin Tan
exaly   +5 more sources

ZO-2 determines cell membrane localization of receptor NTCP and supports hepatitis B virus infection [PDF]

mBio
Hepatitis B virus (HBV) infects hepatocytes by using sodium taurocholate cotransporting polypeptide (NTCP) as a receptor. NTCP can render non-permissive hepatocyte cell lines such as HepG2 permissive to HBV infection.
Hironori Nishitsuji, Saori Yoshimura, Daijiro Konno, Taro Tachibana, Masaya Sugiyama, Manabu Yamasaki, Masashi Mizokami, Takayuki Murata, Kunitada Shimotohno   +8 more
doaj   +2 more sources

Elevated NTCP expression by an iPSC-derived human hepatocyte maintenance medium enhances HBV infection in NTCP-reconstituted HepG2 cells

Cell & Bioscience, 2021
Background The sodium taurocholate cotransporting polypeptide (NTCP) is a functional receptor for hepatitis B virus (HBV). NTCP-reconstituted human hepatoma cells support HBV infection, but the infection is suboptimal and no apparent HBV spread has been ...
Xinlei Li, Zhaohui Xu, Bidisha Mitra, Minghang Wang, Haitao Guo, Zongdi Feng   +5 more
doaj   +3 more sources

NTCP ubiquitination enables HBV infection

JHEP Reports
Background & Aims: The sodium taurocholate cotransporting polypeptide (NTCP), the main hepatic uptake transporter of bile salts, is the docking receptor required for the HBV/HDV entry.
Monique D. Appelman, Thuc-Anh Nguyen, Andreas Oswald, Aaron Lucko, Coen C. Paulusma, Ulrike Protzer, Stan F.J. van de Graaf   +6 more
doaj   +5 more sources

Modeling Normal Tissue Complication Probability of Radiation-Induced Alopecia Following Intensity-Modulated Radiation Therapy in Glioblastoma Patients [PDF]

Advanced Biomedical Research
Background: Glioblastoma multiforme (GBM) is an aggressive primary brain tumor requiring radiotherapy (RT), which often leads to radiation-induced alopecia (RIA), a distressing toxicity impacting quality of life.
Korosh Saber, Mahnaz Roayaei, Ahmad Shanei   +2 more
doaj   +2 more sources

Comparison of Estimated Late Toxicities between IMPT and IMRT Based on Multivariable NTCP Models for High-Risk Prostate Cancers Treated with Pelvic Nodal Radiation [PDF]

International Journal of Particle Therapy, 2022
Purpose: To compare the late gastrointestinal (GI) and genitourinary toxicities (GU) estimated using multivariable normal tissue complication probability (NTCP) models, between pencil-beam scanning proton beam therapy (PBT) and helical tomotherapy (HT ...
Srinivas Chilukuri, MD, Sham Sundar, MD, Kartikeswar Patro, MSc, Mayur Sawant, MSc, Rangasamy Sivaraman, MSc, Manikandan Arjunan, PhD, Pankaj Kumar Panda, MSc, Dayananda Sharma, PhD, Rakesh Jalali, MD   +8 more
doaj   +1 more source

Monte Carlo-based Volumetric Arc Radiation Therapy vs. Helical Tomotherapy in Terms of Tumor Control Probability and Normal Tissue Complication Probability for Endometrial Cancers

Cam & Sakura Medical Journal, 2021
Objective: This study aimed to compare the effectiveness and to plan parameters of the Monte Carlo (MC)-based volumetric arc radiation therapy (VMAT) plan, which was devised using the equivalent uniform dose concept for endometrial cancers, to the dose ...
Sümeyra Can, İlknur Harmankaya, Özge Atilla, Ayben Yentek Balkanay, Didem Karaçetin   +4 more
doaj   +1 more source

Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy

Hepatology, EarlyView., 2022
Serum bile acid levels predict outcomes in patients with biliary atresia who achieve normalized bilirubin levels after Kasai portoenterostomy. Abstract Background and Aims In biliary atresia, serum bilirubin is commonly used to predict outcomes after Kasai portoenterostomy (KP).
Sanjiv Harpavat, Kieran Hawthorne, Kenneth D. R. Setchell, Monica Narvaez Rivas, Lisa Henn, Charlotte A. Beil, Saul J. Karpen, Vicky L. Ng, Estella M. Alonso, Jorge A. Bezerra, Stephen L. Guthery, Simon Horslen, Kathy M. Loomes, Patrick McKiernan, John C. Magee, Robert M. Merion, Jean P. Molleston, Philip Rosenthal, Richard J. Thompson, Kasper S. Wang, Ronald J. Sokol, Benjamin L. Shneider, for Childhood Liver Disease Research Network (ChiLDReN)   +22 more
wiley   +1 more source