Results 1 to 10 of about 14,197 (169)

The Culprit Behind HBV-Infected Hepatocytes: NTCP

Drug Design, Development and Therapy
Shenghao Li,1,2,* Liyuan Hao,1,2,* Jiali Deng,1,2 Junli Zhang,3 Fei Yu,1,2 Fanghang Ye,1,2 Na Li,1,2 Xiaoyu Hu2 1School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, People’s Republic of ...
Fanghang Ye, Fei Yu, JunLi Zhang
exaly   +4 more sources

Targeting NTCP for liver disease treatment: A promising strategy

Journal of Pharmaceutical Analysis
The sodium taurocholate co-transporting polypeptide (NTCP), a bile acids transporter, has been identified as a new therapeutic target for the treatment of liver disease.
Dongke Yu, Jianyou Shi, Xin Tan
exaly   +4 more sources

Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro

Frontiers in Pharmacology, 2023
The sodium taurocholate cotransporting polypeptide (NTCP; gene name SLC10A1) is the primary hepatic basolateral uptake transporter for conjugated bile acids and the entry receptor for the hepatitis B and D virus (HBV/HDV).
Chitra Saran, Chitra Saran, Henry Ho, Paavo Honkakoski, Paavo Honkakoski, Kim L. R. Brouwer   +5 more
doaj   +2 more sources

Tyrosine 146 of the Human Na⁺/Taurocholate Cotransporting Polypeptide (NTCP) Is Essential for Its Hepatitis B Virus (HBV) Receptor Function and HBV Entry into Hepatocytes

Viruses, 2022
Na+/taurocholate cotransporting polypeptide (NTCP, gene symbol SLC10A1) is a hepatic bile acid uptake carrier participating in the enterohepatic circulation of bile acids. Apart from its transporter function, NTCP acts as the high-affinity liver-specific
Dariusz Zakrzewicz, Regina Leidolf, Sebastian Kunz, Simon Franz Müller, Anita Neubauer, Silke Leiting, Nora Goldmann, Felix Lehmann, Dieter Glebe, Joachim Geyer   +9 more
doaj   +2 more sources

NTCP Deficiency Affects the Levels of Circulating Bile Acids and Induces Osteoporosis

Frontiers in Endocrinology, 2022
BackgroundThe p.Ser267Phe mutation in the SLC10A1 gene can cause NTCP deficiency. However, the full clinical presentation of p.Ser267Phe homozygous individuals and its long-term consequences remain unclear.
Fangji Yang, Wenxiong Xu, Lina Wu, Luo Yang, Shu Zhu, Lu Wang, Wenbin Wu, Yuzhen Zhang, Yutian Chong, Yutian Chong, Liang Peng, Liang Peng   +11 more
doaj   +2 more sources

IFITM3 Interacts with the HBV/HDV Receptor NTCP and Modulates Virus Entry and Infection

Viruses, 2022
The Na+/taurocholate co-transporting polypeptide (NTCP, gene symbol SLC10A1) is both a physiological bile acid transporter and the high-affinity hepatic receptor for the hepatitis B and D viruses (HBV/HDV).
Massimo Palatini, Simon Franz Müller, Michael Kirstgen, Silke Leiting, Felix Lehmann, Lena Soppa, Nora Goldmann, Christin Müller, Kira Alessandra Alicia Theresa Lowjaga, Jörg Alber, Giuliano Ciarimboli, John Ziebuhr, Dieter Glebe, Joachim Geyer   +13 more
doaj   +2 more sources

Physiologically Based Pharmacokinetic Modeling to Assess Transporter-Mediated Drug-Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray. [PDF]

Clin Pharmacol Ther
Zavegepant nasal spray, a calcitonin gene‐related peptide receptor antagonist indicated for acute treatment of migraine with or without aura in adults, is a substrate for organic anion transporting polypeptide 1B3 (OATP1B3), Na+/taurocholate cotransporting polypeptide (NTCP), P‐glycoprotein (P‐gp), and cytochrome P450 3A4 (CYP3A4).
Ke A, Callegari E, Varma MVS, Ladumor MK, Muto C, Bertz RJ, Jones HM, Sahasrabudhe V, Liu J.   +8 more
europepmc   +2 more sources

NTCP Oligomerization Occurs Downstream of the NTCP-EGFR Interaction during Hepatitis B Virus Internalization.

Journal of Virology, 2021
Hepatitis B virus (HBV) infection is mediated by a specific interaction with sodium taurocholate-cotransporting polypeptide (NTCP), a viral entry receptor.
Sam-Yong Park, Kousho Wakae, Masamichi Muramatsu   +2 more
exaly   +2 more sources

Perfluoroalkyl Carboxylic Acids Interact with the Human Bile Acid Transporter NTCP

Livers, 2021
Na+/taurocholate cotransporting polypeptide (NTCP) is important for the enterohepatic circulation of bile acids, which has been suggested to contribute to the long serum elimination half-lives of perfluoroalkyl substances in humans.
Melissa J. Ruggiero, Haley Miller, Jessica Y. Idowu, Jeremiah D. Zitzow, Shu-Ching Chang, Bruno Hagenbuch   +5 more
doaj   +2 more sources

Mechanistic insights into the inhibition of NTCP by myrcludex B

JHEP Reports, 2019
Background & aims: The sodium taurocholate co-transporting polypeptide (NTCP) is the entry receptor for the hepatitis B and delta virus (HBV/HDV) and the main hepatic uptake transporter of conjugated bile acids. Myrcludex B, a synthetic peptide mimicking
Stan F van de Graaf, Joanne Donkers
exaly   +3 more sources