Results 1 to 10 of about 9,118 (156)

Mechanistic insights into the inhibition of NTCP by myrcludex B [PDF]

JHEP Reports, 2019
Background & aims: The sodium taurocholate co-transporting polypeptide (NTCP) is the entry receptor for the hepatitis B and delta virus (HBV/HDV) and the main hepatic uptake transporter of conjugated bile acids. Myrcludex B, a synthetic peptide mimicking
Joanne M Donkers, Stan F J Van De Graaf
exaly   +6 more sources

The Culprit Behind HBV-Infected Hepatocytes: NTCP

Drug Design, Development and Therapy
Shenghao Li,1,2,* Liyuan Hao,1,2,* Jiali Deng,1,2 Junli Zhang,3 Fei Yu,1,2 Fanghang Ye,1,2 Na Li,1,2 Xiaoyu Hu2 1School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, People’s Republic of ...
Shenghao Li, Liyuan Hao
exaly   +5 more sources

Targeting NTCP for liver disease treatment: A promising strategy

Journal of Pharmaceutical Analysis
The sodium taurocholate co-transporting polypeptide (NTCP), a bile acids transporter, has been identified as a new therapeutic target for the treatment of liver disease.
Xin Tan, Jianyou Shi, Dongke Yu
exaly   +5 more sources

ZO-2 determines cell membrane localization of receptor NTCP and supports hepatitis B virus infection [PDF]

mBio
Hepatitis B virus (HBV) infects hepatocytes by using sodium taurocholate cotransporting polypeptide (NTCP) as a receptor. NTCP can render non-permissive hepatocyte cell lines such as HepG2 permissive to HBV infection.
Hironori Nishitsuji, Saori Yoshimura, Daijiro Konno, Taro Tachibana, Masaya Sugiyama, Manabu Yamasaki, Masashi Mizokami, Takayuki Murata, Kunitada Shimotohno   +8 more
doaj   +2 more sources

Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro

Frontiers in Pharmacology, 2023
The sodium taurocholate cotransporting polypeptide (NTCP; gene name SLC10A1) is the primary hepatic basolateral uptake transporter for conjugated bile acids and the entry receptor for the hepatitis B and D virus (HBV/HDV).
Chitra Saran, Henry Ho, Paavo Honkakoski   +2 more
exaly   +3 more sources

Elevated NTCP expression by an iPSC-derived human hepatocyte maintenance medium enhances HBV infection in NTCP-reconstituted HepG2 cells

Cell & Bioscience, 2021
Background The sodium taurocholate cotransporting polypeptide (NTCP) is a functional receptor for hepatitis B virus (HBV). NTCP-reconstituted human hepatoma cells support HBV infection, but the infection is suboptimal and no apparent HBV spread has been ...
Xinlei Li, Zhaohui Xu, Bidisha Mitra, Minghang Wang, Haitao Guo, Zongdi Feng   +5 more
doaj   +3 more sources

NTCP ubiquitination enables HBV infection

JHEP Reports
Background & Aims: The sodium taurocholate cotransporting polypeptide (NTCP), the main hepatic uptake transporter of bile salts, is the docking receptor required for the HBV/HDV entry.
Monique D. Appelman, Thuc-Anh Nguyen, Andreas Oswald, Aaron Lucko, Coen C. Paulusma, Ulrike Protzer, Stan F.J. van de Graaf   +6 more
doaj   +5 more sources

Modeling Normal Tissue Complication Probability of Radiation-Induced Alopecia Following Intensity-Modulated Radiation Therapy in Glioblastoma Patients [PDF]

Advanced Biomedical Research
Background: Glioblastoma multiforme (GBM) is an aggressive primary brain tumor requiring radiotherapy (RT), which often leads to radiation-induced alopecia (RIA), a distressing toxicity impacting quality of life.
Korosh Saber, Mahnaz Roayaei, Ahmad Shanei   +2 more
doaj   +2 more sources

Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes

Cell Reports, 2016
Summary: Chronic hepatitis B, C, and D virus (HBV, HCV, and HDV) infections are the leading causes of liver disease and cancer worldwide. Recently, the solute carrier and sodium taurocholate co-transporter NTCP has been identified as a receptor for HBV ...
Éloi R Verrier, Che C Colpitts, Laura Heydmann   +2 more
exaly   +3 more sources

Comparison of Estimated Late Toxicities between IMPT and IMRT Based on Multivariable NTCP Models for High-Risk Prostate Cancers Treated with Pelvic Nodal Radiation [PDF]

International Journal of Particle Therapy, 2022
Purpose: To compare the late gastrointestinal (GI) and genitourinary toxicities (GU) estimated using multivariable normal tissue complication probability (NTCP) models, between pencil-beam scanning proton beam therapy (PBT) and helical tomotherapy (HT ...
Srinivas Chilukuri, MD, Sham Sundar, MD, Kartikeswar Patro, MSc, Mayur Sawant, MSc, Rangasamy Sivaraman, MSc, Manikandan Arjunan, PhD, Pankaj Kumar Panda, MSc, Dayananda Sharma, PhD, Rakesh Jalali, MD   +8 more
doaj   +1 more source