Results 21 to 30 of about 9,177 (185)

Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro

Frontiers in Pharmacology, 2023
The sodium taurocholate cotransporting polypeptide (NTCP; gene name SLC10A1) is the primary hepatic basolateral uptake transporter for conjugated bile acids and the entry receptor for the hepatitis B and D virus (HBV/HDV).
Chitra Saran, Chitra Saran, Henry Ho, Paavo Honkakoski, Paavo Honkakoski, Kim L. R. Brouwer   +5 more
doaj   +1 more source

Quantitative NTCP pharmacophore and lack of association between DILI and NTCP Inhibition [PDF]

European Journal of Pharmaceutical Sciences, 2015
The human sodium taurocholate cotransporting polypeptide (NTCP) is a hepatic bile acid transporter. Inhibition of NTCP uptake may potentially also prevent hepatitis B virus (HBV) infection. The first objective was to develop a quantitative pharmacophore for NTCP inhibition.
Zhongqi, Dong, Sean, Ekins, James E, Polli   +2 more
openaire   +2 more sources

Tyrosine 146 of the Human Na⁺/Taurocholate Cotransporting Polypeptide (NTCP) Is Essential for Its Hepatitis B Virus (HBV) Receptor Function and HBV Entry into Hepatocytes

Viruses, 2022
Na+/taurocholate cotransporting polypeptide (NTCP, gene symbol SLC10A1) is a hepatic bile acid uptake carrier participating in the enterohepatic circulation of bile acids. Apart from its transporter function, NTCP acts as the high-affinity liver-specific
Dariusz Zakrzewicz, Regina Leidolf, Sebastian Kunz, Simon Franz Müller, Anita Neubauer, Silke Leiting, Nora Goldmann, Felix Lehmann, Dieter Glebe, Joachim Geyer   +9 more
doaj   +1 more source

Proton beam therapy in paediatric cancer: Anticipating the opening of the Australian Bragg Centre for Proton Therapy and Research

Journal of Medical Imaging and Radiation Oncology, EarlyView., 2023
Summary Proton Beam Therapy (PBT) has the potential to improve paediatric cancer care by reducing radiation exposure and thus long‐term toxicities. Ethical concerns and debates surrounding the treatment, such as eligibility and accessibility, are ongoing in Australia. The Australian Bragg Centre for Proton Therapy and Research (ABCPTR) (named after Sir
Jeremy Khong, Hui Tee, Peter Gorayski, Hien Le, Michael Penniment, Sophie Jessop, Jordan Hansford, Melanie Penfold, Julia Green, Kelly Skelton, Frank Saran   +10 more
wiley   +1 more source

NTCP Deficiency Affects the Levels of Circulating Bile Acids and Induces Osteoporosis

Frontiers in Endocrinology, 2022
BackgroundThe p.Ser267Phe mutation in the SLC10A1 gene can cause NTCP deficiency. However, the full clinical presentation of p.Ser267Phe homozygous individuals and its long-term consequences remain unclear.
Fangji Yang, Wenxiong Xu, Lina Wu, Luo Yang, Shu Zhu, Lu Wang, Wenbin Wu, Yuzhen Zhang, Yutian Chong, Yutian Chong, Liang Peng, Liang Peng   +11 more
doaj   +1 more source

IFITM3 Interacts with the HBV/HDV Receptor NTCP and Modulates Virus Entry and Infection

Viruses, 2022
The Na+/taurocholate co-transporting polypeptide (NTCP, gene symbol SLC10A1) is both a physiological bile acid transporter and the high-affinity hepatic receptor for the hepatitis B and D viruses (HBV/HDV).
Massimo Palatini, Simon Franz Müller, Michael Kirstgen, Silke Leiting, Felix Lehmann, Lena Soppa, Nora Goldmann, Christin Müller, Kira Alessandra Alicia Theresa Lowjaga, Jörg Alber, Giuliano Ciarimboli, John Ziebuhr, Dieter Glebe, Joachim Geyer   +13 more
doaj   +1 more source

N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection.

PLoS ONE, 2017
The sodium/bile acid cotransporter NTCP was recently identified as a receptor for hepatitis B virus (HBV). NTCP is glycosylated and the role of glycans in protein trafficking or viral receptor activity is not known.
Monique D Appelman, Anindita Chakraborty, Ulrike Protzer, Jane A McKeating, Stan F J van de Graaf   +4 more
doaj   +1 more source

Analytical investigation of properties of the iso-NTCP envelope [PDF]

Radiology and Oncology, 2007
Background. A property of the integral dose-volume histogram (DVH) space is analytically investigated in this work. A curve called an α-iso-NTCP (normal tissue complication probability) envelope is constructed by connecting points belonging to step-like integral DVHs, each corresponding to homogeneous partial organ irradiation of a relative volume vk ...
Fallone, B. Gino, Markov, Krassimir, Schinkel, Colleen, Stavrev, Pavel, Stavreva, Nadia   +4 more
openaire   +2 more sources

Mutational Analysis of the GXXXG/A Motifs in the Human Na+/Taurocholate Co-Transporting Polypeptide NTCP on Its Bile Acid Transport Function and Hepatitis B/D Virus Receptor Function

Frontiers in Molecular Biosciences, 2021
Homodimerization is essential for plasma membrane sorting of the liver bile acid transporter NTCP and its function as Hepatitis B/D Virus (HBV/HDV) receptor. However, the protein domains involved in NTCP dimerization are unknown. NTCP bears two potential
Massimo Palatini, Simon Franz Müller, Kira Alessandra Alicia Theresa Lowjaga, Saskia Noppes, Jörg Alber, Felix Lehmann, Nora Goldmann, Dieter Glebe, Joachim Geyer   +8 more
doaj   +1 more source

Evaluation of NTCP and Second Cancer Induction from Modulated Arc Therapy for High-Risk Prostate Carcinoma by COUPÔLE Software [PDF]

Iranian Journal of Medical Physics
Introduction: Assessing the toxicity and the risk of radiation-induced secondary cancer is crucial for optimizing treatment planning in prostate carcinoma patients with high risk undergoing Volumetric Modulated Arc Therapy (VMAT).
Assya Boughalia, Mohamed Fellah, Mohamed Zineddine El Ghribi, Kenza Benacer   +3 more
doaj   +1 more source