Results 21 to 30 of about 16,210 (241)

HepG2-NTCP Subclones Exhibiting High Susceptibility to Hepatitis B Virus Infection [PDF]

Viruses, 2022
HepG2 cells reconstituted with Hepatitis B virus (HBV) entry receptor sodium taurocholate co-transporting polypeptide (NTCP) are widely used as a convenient in vitro cell culture infection model for HBV replication studies.
Muhammad Atif Zahoor, Adrian Kuipery, Alexander I. Mosa, Adam J. Gehring, Jordan J. Feld   +4 more
doaj   +3 more sources

An NTCP Analysis of Urethral Complications from Low Doserate Mono- and Bi-Radionuclide Brachytherapy [PDF]

Prostate Cancer, 2011
Urethral NTCP has been determined for three prostates implanted with seeds based on 125I (145 Gy), 103Pd (125 Gy), 131Cs (115 Gy), 103Pd-125I (145 Gy), or 103Pd-131Cs (115 Gy or 130 Gy).
V. E. Nuttens, A. E. Nahum, S. Lucas
doaj   +2 more sources

In Vitro Infection with Hepatitis B Virus Using Differentiated Human Serum Culture of Huh7.5-NTCP Cells without Requiring Dimethyl Sulfoxide

Viruses, 2021
An estimated two billion people worldwide have been infected with hepatitis B virus (HBV). Despite the high infectivity of HBV in vivo, a lack of easily infectable in vitro culture systems hinders studies of HBV. Overexpression of the sodium taurocholate
Connie Le, Reshma Sirajee, Rineke Steenbergen, Michael A. Joyce, William R. Addison, D. Lorne Tyrrell   +5 more
doaj   +2 more sources

Identification of amino acids restricting HBV receptor function in porcine NTCP [PDF]

npj Viruses
With 254 million chronically infected patients, hepatitis B virus (HBV) continues to be a severe health threat. While animal models play a crucial role in developing new therapies, the availability of preclinical HBV models is very limited.
Samuel D. Jeske, Jochen M. Wettengel, Florian Gegenfurtner, Konrad Fischer, Judith Moosmüller, Anindita Chakraborty, Chunkyu Ko, Benjamin J. Burwitz, Angelika Schnieke, Ulrike Protzer   +9 more
doaj   +2 more sources

Monte Carlo-based Volumetric Arc Radiation Therapy vs. Helical Tomotherapy in Terms of Tumor Control Probability and Normal Tissue Complication Probability for Endometrial Cancers

Cam & Sakura Medical Journal, 2021
Objective: This study aimed to compare the effectiveness and to plan parameters of the Monte Carlo (MC)-based volumetric arc radiation therapy (VMAT) plan, which was devised using the equivalent uniform dose concept for endometrial cancers, to the dose ...
Sümeyra Can, İlknur Harmankaya, Özge Atilla, Ayben Yentek Balkanay, Didem Karaçetin   +4 more
doaj   +1 more source

Structural insights into the HBV receptor and bile acid transporter NTCP

Nature, 2022
Around 250 million people are infected with hepatitis B virus (HBV) worldwide1, and 15 million may also carry the satellite virus hepatitis D virus (HDV), which confers even greater risk of severe liver disease2.
Jae-Hyun Park, Masashi Iwamoto, J. Yun, Tomomi Uchikubo-Kamo, Donghwan Son, Zeyu Jin, H. Yoshida, M. Ohki, N. Ishimoto, K. Mizutani, M. Oshima, M. Muramatsu, T. Wakita, M. Shirouzu, Kehong Liu, Tomoko Uemura, N. Nomura, S. Iwata, Koichi Watashi, J. Tame, T. Nishizawa, Weontae Lee, Sam-Yong Park   +22 more
semanticscholar   +1 more source

Conserved use of the sodium/bile acid cotransporter (NTCP) as an entry receptor by hepatitis B virus and domestic cat hepadnavirus

bioRxiv, 2023
The Orthohepadnavirus genus includes hepatitis B virus (HBV) that can cause chronic hepatitis and hepatocarcinoma in humans. Recently, a novel hepadnavirus in cats, domestic cat hepadnavirus (DCH), was identified that is genetically close to HBV.
Maya Shofa, Akiho Ohkawa, Y. Kaneko, Akatsuki Saito   +3 more
semanticscholar   +1 more source

Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy

Hepatology, EarlyView., 2022
Serum bile acid levels predict outcomes in patients with biliary atresia who achieve normalized bilirubin levels after Kasai portoenterostomy. Abstract Background and Aims In biliary atresia, serum bilirubin is commonly used to predict outcomes after Kasai portoenterostomy (KP).
Sanjiv Harpavat, Kieran Hawthorne, Kenneth D. R. Setchell, Monica Narvaez Rivas, Lisa Henn, Charlotte A. Beil, Saul J. Karpen, Vicky L. Ng, Estella M. Alonso, Jorge A. Bezerra, Stephen L. Guthery, Simon Horslen, Kathy M. Loomes, Patrick McKiernan, John C. Magee, Robert M. Merion, Jean P. Molleston, Philip Rosenthal, Richard J. Thompson, Kasper S. Wang, Ronald J. Sokol, Benjamin L. Shneider, for Childhood Liver Disease Research Network (ChiLDReN)   +22 more
wiley   +1 more source

Quantitative NTCP pharmacophore and lack of association between DILI and NTCP Inhibition [PDF]

European Journal of Pharmaceutical Sciences, 2015
The human sodium taurocholate cotransporting polypeptide (NTCP) is a hepatic bile acid transporter. Inhibition of NTCP uptake may potentially also prevent hepatitis B virus (HBV) infection. The first objective was to develop a quantitative pharmacophore for NTCP inhibition.
Zhongqi, Dong, Sean, Ekins, James E, Polli   +2 more
openaire   +2 more sources

Automated clinical decision support system with deep learning dose prediction and NTCP models to evaluate treatment complications in patients with esophageal cancer.

Radiotherapy and Oncology, 2022
BACKGROUND AND PURPOSE This study aims to investigate how accurate our deep learning (DL) dose prediction models for intensity modulated radiotherapy (IMRT) and pencil beam scanning (PBS) treatments, when chained with normal tissue complication ...
C. Draguet, Ana M. Barragán-Montero, M. Chocan Vera, Melissa Thomas, P. Populaire, G. Defraene, K. Haustermans, J. Lee, E. Sterpin   +8 more
semanticscholar   +1 more source