Results 21 to 30 of about 17,063 (199)

Structural insights into the HBV receptor and bile acid transporter NTCP

Nature, 2022
Around 250 million people are infected with hepatitis B virus (HBV) worldwide1, and 15 million may also carry the satellite virus hepatitis D virus (HDV), which confers even greater risk of severe liver disease2.
Jae-Hyun Park, Masashi Iwamoto, J. Yun, Tomomi Uchikubo-Kamo, Donghwan Son, Ze-Yu Jin, H. Yoshida, M. Ohki, N. Ishimoto, K. Mizutani, M. Oshima, M. Muramatsu, T. Wakita, M. Shirouzu, Kehong Liu, Tomoko Uemura, N. Nomura, S. Iwata, K. Watashi, J. Tame, T. Nishizawa, Weontae Lee, Sam-Yong Park   +22 more
semanticscholar   +1 more source

Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy

Hepatology, EarlyView., 2022
Serum bile acid levels predict outcomes in patients with biliary atresia who achieve normalized bilirubin levels after Kasai portoenterostomy. Abstract Background and Aims In biliary atresia, serum bilirubin is commonly used to predict outcomes after Kasai portoenterostomy (KP).
Sanjiv Harpavat, Kieran Hawthorne, Kenneth D. R. Setchell, Monica Narvaez Rivas, Lisa Henn, Charlotte A. Beil, Saul J. Karpen, Vicky L. Ng, Estella M. Alonso, Jorge A. Bezerra, Stephen L. Guthery, Simon Horslen, Kathy M. Loomes, Patrick McKiernan, John C. Magee, Robert M. Merion, Jean P. Molleston, Philip Rosenthal, Richard J. Thompson, Kasper S. Wang, Ronald J. Sokol, Benjamin L. Shneider, for Childhood Liver Disease Research Network (ChiLDReN)   +22 more
wiley   +1 more source

Molecular insight into the bile acid transporter NTCP [PDF]

, 2020
Bile acids have besides their emulsification function in the intestine also a signalling role in many metabolic pathways. Bile acids circulate in the body via the enterohepatic circulation.
Appelman, M.D.
core   +16 more sources

Conserved use of the sodium/bile acid cotransporter (NTCP) as an entry receptor by hepatitis B virus and domestic cat hepadnavirus

bioRxiv, 2023
The Orthohepadnavirus genus includes hepatitis B virus (HBV) that can cause chronic hepatitis and hepatocarcinoma in humans. Recently, a novel hepadnavirus in cats, domestic cat hepadnavirus (DCH), was identified that is genetically close to HBV.
Maya Shofa, Akiho Ohkawa, Y. Kaneko, Akatsuki Saito   +3 more
semanticscholar   +1 more source

Automated clinical decision support system with deep learning dose prediction and NTCP models to evaluate treatment complications in patients with esophageal cancer.

Radiotherapy and Oncology, 2022
BACKGROUND AND PURPOSE This study aims to investigate how accurate our deep learning (DL) dose prediction models for intensity modulated radiotherapy (IMRT) and pencil beam scanning (PBS) treatments, when chained with normal tissue complication ...
C. Draguet, A. Barragán-Montero, M. Chocan Vera, Melissa Thomas, P. Populaire, G. Defraene, K. Haustermans, J. Lee, E. Sterpin   +8 more
semanticscholar   +1 more source

Proton beam therapy in paediatric cancer: Anticipating the opening of the Australian Bragg Centre for Proton Therapy and Research

Journal of Medical Imaging and Radiation Oncology, EarlyView., 2023
Summary Proton Beam Therapy (PBT) has the potential to improve paediatric cancer care by reducing radiation exposure and thus long‐term toxicities. Ethical concerns and debates surrounding the treatment, such as eligibility and accessibility, are ongoing in Australia. The Australian Bragg Centre for Proton Therapy and Research (ABCPTR) (named after Sir
Jeremy Khong, Hui Tee, Peter Gorayski, Hien Le, Michael Penniment, Sophie Jessop, Jordan Hansford, Melanie Penfold, Julia Green, Kelly Skelton, Frank Saran   +10 more
wiley   +1 more source

Normal Tissue Complication Probability (NTCP) Prediction Model for Osteoradionecrosis of the Mandible in Patients With Head and Neck Cancer After Radiation Therapy: Large-Scale Observational Cohort

medRxiv, 2021
Background and purpose. Osteoradionecrosis (ORN) of the mandible represents a severe, debilitating complication of radiation therapy (RT) for head and neck cancer (HNC).
L. V. van Dijk, A. Abusaif, Jillian M Rigert, M. Naser, K. Hutcheson, S. Lai, C. Fuller, A. Mohamed   +7 more
semanticscholar   +1 more source

Regulation of the HBV Entry Receptor NTCP and its Potential in Hepatitis B Treatment

Frontiers in Molecular Biosciences, 2022
Hepatitis B virus (HBV) is a globally prevalent human DNA virus responsible for more than 250 million cases of chronic liver infection, a condition that can lead to liver inflammation, cirrhosis, and hepatocellular carcinoma.
Yan Li, Jun Zhou, Tian-Liang Li
semanticscholar   +1 more source

Multitasking Na+/Taurocholate Cotransporting Polypeptide (NTCP) as a Drug Target for HBV Infection: From Protein Engineering to Drug Discovery

Biomedicines, 2022
Hepatitis B virus (HBV) infections are among the major public health concerns worldwide with more than 250 million of chronically ill individuals. Many of them are additionally infected with the Hepatitis D virus, a satellite virus to HBV.
Dariusz Zakrzewicz, J. Geyer
semanticscholar   +1 more source

The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro

PLoS Pathogens, 2022
Intracellular transport via microtubule-based dynein and kinesin family motors plays a key role in viral reproduction and transmission. We show here that Kinesin Family Member 4 (KIF4) plays an important role in HBV/HDV infection.
Sameh A. Gad, M. Sugiyama, M. Tsuge, K. Wakae, Kento Fukano, M. Oshima, C. Sureau, N. Watanabe, Takanobu Kato, Asako Murayama, Yingfang Li, Ikuo Shoji, K. Shimotohno, K. Chayama, M. Muramatsu, T. Wakita, T. Nozaki, Hussein H. Aly   +17 more
semanticscholar   +1 more source