DataSheet1_Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro.pdf [PDF]
, 2023 The sodium taurocholate cotransporting polypeptide (NTCP; gene name SLC10A1) is the primary hepatic basolateral uptake transporter for conjugated bile acids and the entry receptor for the hepatitis B and D virus (HBV/HDV).
Paavo Honkakoski (2110219) +3 more
core +1 more source
HBV infection of wild type and glycosylation deficient NTCP variants. [PDF]
, 2017 HepG2 cells stably expressing NTCP-WT, NTCP-N5Q, NTCP-N11Q or NTCP-N5,11Q were infected with HBV. (A) 3 days post infection, HBeAg production was measured by ELISA.
Stan F. J. van de Graaf (486942) +4 more
core +1 more source
Evaluation of NTCP and Second Cancer Induction from Modulated Arc Therapy for High-Risk Prostate Carcinoma by COUPÔLE Software [PDF]
Iranian Journal of Medical PhysicsIntroduction: Assessing the toxicity and the risk of radiation-induced secondary cancer is crucial for optimizing treatment planning in prostate carcinoma patients with high risk undergoing Volumetric Modulated Arc Therapy (VMAT).
Assya Boughalia +3 more
doaj +1 more source
Radiotherapy and Oncology, 2021 BACKGROUND AND PURPOSE Accurate segmentation of organs-at-risk (OARs) is crucial but tedious and time-consuming in adaptive radiotherapy (ART). The purpose of this work was to automate head and neck OAR-segmentation on repeat CT (rCT) by an optimal ...
Yong Gan +7 more
semanticscholar +1 more source
Effect of NTCP glycosylation on bile acid transport activity. [PDF]
, 2017 Taurocholate (TCA) uptake assay in parental HepG2 cells and those stably expressing NTCP-WT, NTCP-N5Q, NTCP-N11Q or NTCP-N5,11Q. Cells were incubated for 2 minutes with uptake buffer containing 20 mM taurocholate, spiked with [3H]-taurocholate.
Stan F. J. van de Graaf (486942) +4 more
core +1 more source
Interaction of KIF4 and NTCP over microtubule filaments. [PDF]
, 2022 (A) HepG2-hNTCP were transfected with a Halo-tagged KIF4 expression vector or empty vector (control). At 48 h post-transfection, the cells were incubated with HaloTag TMR ligand for 15 min at 37°C; after being washed, cells were fixed, and permeabilized.
Hussein H. Aly (12269985) +17 more
core +1 more source
Viruses, 2019 More than 350 million people worldwide have been persistently infected with the hepatitis B virus (HBV). Chronic HBV infection could advance toward liver cirrhosis and hepatocellular carcinoma.
Khanit Sa-ngiamsuntorn +7 more
doaj +1 more source
Vaccines, 2022 (1) Background: Sodium taurocholate cotransporting polypeptide (NTCP) functions as a key receptor for the hepatitis B virus (HBV) infection. Analyzing HBV and NTCP interaction is an important issue not only for basic research but also for the development
Shuji Hinuma +2 more
doaj +1 more source
Effect of N-linked glycosylation on NTCP plasma membrane expression. [PDF]
, 2017 Plasma membrane expression was assessed by surface-biotinylation of parental HepG2 cells or those expressing NTCP-WT, NTCP-N5Q, NTCP-N11Q, NTCP-N5,11Q. (A) Representative immunoblot for NTCP membrane expression and for the Transferrin receptor (TfR), as ...
Stan F. J. van de Graaf (486942) +4 more
core +1 more source
Dosimetric Validation of Physical and Biological Indexes from the Dose-Volume Histogram for Evaluation of 3D-CRT and IMRT Techniques with VMAT Treatment Plan Techniques in Cervical Tumors from In-House Developed Software [PDF]
Iranian Journal of Medical PhysicsIntroduction:This study aims to investigate the Normal Tissue Complication Probability (NTCP) and Tumor Control Probability (TCP) of cervical cancer from Niemierko radiobiological model and compared with Lyman-Kutcher-Butcher (LKB) model’s effective ...
Sougoumarane Dashnamoorthy +5 more
doaj +1 more source