Results 51 to 60 of about 9,177 (185)

Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy

open access: yesBreast, 2023
Background: Normal tissue complication probability (NTCP) models can be useful to estimate the risk of fibrosis after breast-conserving surgery (BCS) and radiotherapy (RT) to the breast. However, they are subject to uncertainties.
Tanwiwat Jaikuna   +24 more
doaj   +1 more source

Normal tissue complication probability models of late cardiopulmonary toxicity following deep inspiration breath hold for breast cancer adjuvant radiotherapy

open access: yesPrecision Radiation Oncology, EarlyView.
Deep inspiration breath hold (DIBH) markedly cuts heart and left lung radiation doses during left‐sided breast cancer radiotherapy. The normal tissue complication probability (NTCP) model further confirms lower predicted cardiopulmonary toxicities versus free breathing (FB), potentially improving patients’ quality of life.
Lin Lin   +10 more
wiley   +1 more source

Systematic reduction of hyperspectral images for high-throughput plastic characterization

open access: yesScientific Reports, 2023
Hyperspectral Imaging (HSI) combines microscopy and spectroscopy to assess the spatial distribution of spectroscopically active compounds in objects, and has diverse applications in food quality control, pharmaceutical processes, and waste sorting ...
Mahdiyeh Ghaffari   +6 more
doaj   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux   +6 more
wiley   +1 more source

NTCP Change in Rats of Hilar Cholangiocarcinoma and Therapeutic Significance

open access: yesTechnology in Cancer Research & Treatment, 2022
Background: The study aims to detect the expression of Na + /taurocholate cotransporter polypeptide in hilar cholangiocarcinoma of rat model, to provide a new therapeutic target for gene therapy of hilar cholangiocarcinoma.
Meng-yu Zhang   +4 more
openaire   +3 more sources

In Vitro Infection with Hepatitis B Virus Using Differentiated Human Serum Culture of Huh7.5-NTCP Cells without Requiring Dimethyl Sulfoxide

open access: yesViruses, 2021
An estimated two billion people worldwide have been infected with hepatitis B virus (HBV). Despite the high infectivity of HBV in vivo, a lack of easily infectable in vitro culture systems hinders studies of HBV. Overexpression of the sodium taurocholate
Connie Le   +5 more
doaj   +1 more source

Self‐Organized Vascularized Human Liver Spheroids: Serum‐Free Culture Conditions and Use as Tissue Building Blocks

open access: yesSmall, EarlyView.
This approach addresses a major challenge in tissue engineering: creating larger, vascularized tissues. Microvascular networks in liver spheroids are developed through self‐organization mediated by mesenchymal stem cells. These spheroids are maintained in serum‐reduced or serum‐free medium and serve as building blocks to form planar tissue layers ...
Alina Filatova   +10 more
wiley   +1 more source

Progress in bone tissue engineering biomaterials: Development, challenges, and prospects

open access: yesVIEW, EarlyView.
Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang   +7 more
wiley   +1 more source

Establishment of a human cell line with a surface display system for screening and optimizing Na+-taurocholate cotransporting polypeptide-binding peptides

open access: yesFrontiers in Microbiology, 2022
One of the most desirable targets for HBV medications is the sodium taurocholate cotransporting polypeptide (NTCP), an entry receptor for the hepatitis B virus (HBV). N-myristoylated preS1 2–48 (Myrcludex B or Hepcludex), an NTCP-binding peptide from the
Pei-yun Wang   +13 more
doaj   +1 more source

Rare Variants in PFIC‐Related Genes Among Adults With Intrahepatic Cholestasis

open access: yesHepatology Research, EarlyView.
ABSTRACT Aim Biallelic pathogenic variants in progressive familial intrahepatic cholestasis (PFIC)‐related genes cause severe pediatric cholestasis. However, the clinical significance of heterozygous variants in adult intrahepatic cholestasis remains unclear.
Shunji Hirose   +9 more
wiley   +1 more source

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