Results 191 to 200 of about 16,210 (241)

NTCP: a pharmacological target for multiple liver conditions

Gut, 2021
Despite major therapeutic advances to treat patients with chronic liver diseases, one target remains elusive in hepatology and this is the most important one: liver fibrosis. We can cure patients from chronic hepatitis C; we can vaccinate against hepatitis B virus and control chronic hepatitis B; we have new drugs to treat cholestatic liver diseases ...
Jordi Gracia-Sancho, Jean-François Dufour   +1 more
openaire   +2 more sources

Concept of Viral Inhibitors via NTCP

Seminars in Liver Disease, 2019
AbstractIdentification of sodium taurocholate cotransporting polypeptide (NTCP) as an entry receptor for hepatitis B and D viruses (HBV and HDV) has not only promoted our understanding of the mechanism underlying the viral entry process, but also provided cell culture models supporting viral infection.
Kento, Fukano, Senko, Tsukuda, Koichi, Watashi, Takaji, Wakita   +3 more
openaire   +2 more sources

Ergosterol peroxide inhibits HBV infection by inhibiting the binding of the pre-S1 domain of LHBsAg to NTCP.

Antiviral Research, 2021
Hepatitis B virus (HBV) infection leads to severe liver diseases, including cirrhosis and hepatocellular carcinoma (HCC). More than 257 million individuals are chronically infected, particularly in the Western Pacific region and Africa.
Hsing-Yen Huang, Hsiu-Chen Huang, Wei-Chung Chiou, Lie-Chwen Lin, Jui-Chieh Chen, Hui-Kang Liu, Yu-Heng Lai, Cheng Huang   +7 more
semanticscholar   +1 more source

Design of Dimeric Bile Acid Derivatives as Potent and Selective Human NTCP Inhibitors.

Journal of Medicinal Chemistry, 2021
Dimeric bile acid derivatives (DBADs) were developed and tested for their anti-HBV and anti-HDV activities as sodium taurocholate cotransporting polypeptide (NTCP) inhibitors.
Yang Liu, Lei Zhang, Huan Yan, Zhiqiang Wang, Guoliang Sun, Xiao Song, Zhongmin Zhou, Bo Peng, Liwei Yan, Qingcui Wu, Wenhui Li, X. Qi   +11 more
semanticscholar   +1 more source

Identification of patient benefit from proton beam therapy in brain tumour patients based on dosimetric and NTCP analyses.

Radiotherapy and Oncology, 2021
BACKGROUND The limited availability of proton beam therapy (PBT) requires individual treatment selection strategies, such as the model-based approach. In this study, we assessed the dosimetric benefit of PBT compared to photon therapy (XRT), analysed the
A. Dutz, A. Lühr, E. Troost, L. Agolli, R. Bütof, C. Valentini, M. Baumann, X. Vermeren, D. Geismar, B. Timmermann, M. Krause, Steffen Loeck   +11 more
semanticscholar   +1 more source

A representation of an NTCP function for local complication mechanisms

Physics in Medicine and Biology, 2001
A mathematical formalism was tailored for the description of mechanisms complicating radiation therapy with a predominantly local component. The functional representation of an NTCP function was developed based on the notion that it has to be robust against population averages in order to be applicable to experimental data. The model was required to be
M, Alber, F, Nüsslin
openaire   +2 more sources

HBV: Stowaway of NTCP

Clinics and Research in Hepatology and Gastroenterology, 2014
Several recent papers support the view that Na-taurocholate cotransporting polypeptide (NTCP), the sinusoidal bile acid transporter of hepatocytes, is a cell surface receptor enabling entry into these cells of the hepatitis B virus (HBV). This major advance in the understanding of the HBV life cycle paves the way to new therapeutic strategies aimed at ...
openaire   +2 more sources

Validation of automatic segmentation of ribs for NTCP modeling

Radiotherapy and Oncology, 2016
Determination of a dose-effect relation for rib fractures in a large patient group has been limited by the time consuming manual delineation of ribs. Automatic segmentation could facilitate such an analysis. We determine the accuracy of automatic rib segmentation in the context of normal tissue complication probability modeling (NTCP).Forty-one ...
Barbara Stam, Heike Peulen, Maddalena M.G. Rossi, José S.A. Belderbos, Jan-Jakob Sonke   +4 more
openaire   +2 more sources

Integrated plasma and liver gas chromatography mass spectrometry and liquid chromatography mass spectrometry metabolomics to reveal physiological functions of sodium taurocholate cotransporting polypeptide (NTCP) with an Ntcp knockout mouse model.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2021
Sodium taurocholate cotransporting polypeptide (NTCP) is an important hepatocyte transporter, while its physiological functions require further investigation.
Qisong Zhang, Zhuoru He, Zhongqiu Liu, Lingzhi Gong   +3 more
semanticscholar   +1 more source

Absolute measurement of species differences in sodium taurocholate cotransporting polypeptide (NTCP/Ntcp) and its modulation in cultured hepatocytes

Journal of Pharmaceutical Sciences, 2013
Species differences among membrane transporters can be remarkable and difficult to properly assess by conventional methods. Herein, we employed the first use of stable isotope labeling in mammals or stable isotope-labeled peptides combined with mass spectrometry to identify species differences in sodium taurocholate cotransporting polypeptide (NTCP ...
Xi, Qiu, Yi-An, Bi, Larissa M, Balogh, Yurong, Lai   +3 more
openaire   +2 more sources