Results 201 to 210 of about 16,210 (241)

NTCP-Reconstituted In Vitro HBV Infection System

2016
Sodium taurocholate cotransporting polypeptide (NTCP) has been identified as a functional receptor for hepatitis B virus (HBV). Expressing human NTCP in human hepatoma HepG2 cells (HepG2-NTCP) renders these cells susceptible for HBV infection. The HepG2-NTCP stably transfected cell line provides a much-needed and easily accessible platform for studying
Yinyan, Sun, Yonghe, Qi, Bo, Peng, Wenhui, Li   +3 more
openaire   +2 more sources

Tanshinone IIA prevents rifampicin‐induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2

Liver international (Print), 2020
Rifampicin (RFP)‐induced cholestatic liver injury is characterized by impaired hepatic bile acid (BA) transport. Bile salt efflux pump (BSEP) and Na+/taurocholate cotransporter (NTCP) are the major BA transporters.
Yujie Yang, Lei Liu, Xiqian Zhang, Xuehua Jiang, Ling Wang   +4 more
semanticscholar   +1 more source

Generalizability assessment of head and neck cancer NTCP models based on the TRIPOD criteria.

Radiotherapy and Oncology, 2020
This review aimed to provide an overview of the level of maturity of normal tissue complication probability (NTCP) models for head and neck cancer (HNC) patients.
M. Sharabiani, E. Clementel, N. Andratschke, C. Hurkmans   +3 more
semanticscholar   +1 more source

On the limitations of the area under the ROC curve for NTCP modelling

Radiotherapy and Oncology, 2020
The area under the ROC curve (AUC) is commonly used as a measure for the discriminative performance of NTCP models. Here, we demonstrate that for typical patient cohorts, the AUC is an unsuitable measure for that purpose since it is typically limited to values below 0.8 and it exhibits large statistical variation.
Emanuel Bahn, Markus Alber
openaire   +2 more sources

NTCP model for hypothyroidism after supraclavicular-directed radiation therapy for breast cancer.

Radiotherapy and Oncology, 2020
BACKGROUND AND PURPOSE Hypothyroidism (HT) is a well-known complication of radiation (RT) that includes supraclavicular (SCV) fields. We analyzed breast cancer patients who received SCV-directed RT to evaluate predictors of HT and developed the first ...
Huakang Huang, J. Roberson, W. Hou, K. Mani, E. Valentine, S. Ryu, A. Stessin   +6 more
semanticscholar   +1 more source

In vitro functional characterization and in silico prediction of rare genetic variation in the bile acid and drug transporter, Na+-taurocholate co-transporting polypeptide (NTCP, SLC10A1).

Molecular Pharmaceutics, 2020
Na+-taurocholate co-transporting polypeptide (NTCP; SLC10A1) is a key hepatic uptake transporter for bile acids and drugs and is the main functional receptor for hepatitis B and D viruses. Next-generation sequencing (NGS) has revealed that a large number
Laura E Russell, Yitian Zhou, V. Lauschke, R. Kim   +3 more
semanticscholar   +1 more source

TCP and NTCP: a basic introduction.

Rays, 2006
Radiotherapy is one of the most effective treatments for cancer. The aim of radiotherapy is to achieve a high probability of local tumor control (tumor control probability, TCP) at a low risk of normal tissue complications (normal tissue complication probability, NTCP).
Michael, Baumann, Cordula, Petersen
openaire   +1 more source

Modeling clinical outcomes in radiotherapy: NTCP, TCP and the “TECs”

Medical Physics, 2023
AbstractRadiation therapy is a double‐edged sword which damages both tumor and normal cells. Achieving treatments with high tumor control probability (TCP) yet low normal tissue complication probability (NTCP) is often a struggle because we rarely have a unified understanding of the dosimetric and clinical correlates of the desired outcomes.
openaire   +2 more sources

A NTCP approach for estimating the outcome in radioiodine treatment of hyperthyroidism

Medical Physics, 2008
Radioiodine has been in use for over as a treatment for hyperthyroidism. Major changes in clinical practice have led to accurate dosimetry capable of avoiding the risks of adverse effects and the optimization of the treatment. The aim of this study was to test the capability of a radiobiological model, based on normal tissue complication probability ...
L, Strigari, R, Sciuto, M, Benassi, S, Bergomi, S, Nocentini, C L, Maini   +5 more
openaire   +2 more sources

Modelling of Normal Tissue Complication Probabilities (NTCP): Review of Application of Machine Learning in Predicting NTCP

2015
Predicting normal tissue toxicity following radiotherapy is a multidimensional challenge. The dose received by healthy tissue surrounding the tumour is described using a 3D dose distribution. In addition, patient- and treatment-related factors must also be considered in any predictive model of toxicity.
openaire   +1 more source