Results 141 to 150 of about 2,522,601 (164)

Combining xQTL and genome-wide association studies from diverse populations improves druggable gene discovery. [PDF]

Nat Commun
Lorincz-Comi N, Song W, Chen X, Paz IR, Hou Y, Zhou Y, Xu J, Martin W, Barnard J, Pieper AA, Haines JL, Chung MK, Cheng F.   +12 more
europepmc   +1 more source

How to manage radioiodine-refractory thyroid cancer in the era of precision medicine. [PDF]

Drugs Context
Karapanou O, Effraimidis G, Michalaki M, Saltiki K.   +3 more
europepmc   +1 more source

Application Value of Multi-Gene Testing in the Evaluation of Benign and Malignant Thyroid Nodules. [PDF]

Iran J Biotechnol
Zhang M, Xie L, Xu F, Liu L, Wang Y, Jiang J, Fei W, Jiang Z, Hu X.   +8 more
europepmc   +1 more source

Infant-Type Hemispheric Glioma With NTRK Fusion Responds to Larotrectinib. [PDF]

Cureus
Jain PV, Rumler S, North P.
europepmc   +1 more source

Oncogenic influences of neurotrophin receptors: Shedding light on Trk biology. [PDF]

Cell Rep
Jagana HL, Shabar MM, Jackson TS, Johnson DE, Hemenway JM, Mukkamala V, Lukasik A, Hathaway MR, Pattwell SS.   +8 more
europepmc   +1 more source

ALK, ROS1, RET and NTRK1–3 Gene Fusions in Colorectal and Non-Colorectal Microsatellite-Unstable Cancers

International Journal of Molecular Sciences, 2023
This study aimed to conduct a comprehensive analysis of actionable gene rearrangements in tumors with microsatellite instability (MSI). The detection of translocations involved tests for 5′/3′-end expression imbalance, variant-specific PCR ...
Elena Preobrazhenskaya, Vladislav Tiurin, Aleksandr Martianov   +2 more
exaly   +2 more sources

Cost-Efficient Detection of NTRK1/2/3 Gene Fusions: Single-Center Analysis of 8075 Tumor Samples

International Journal of Molecular Sciences, 2023
The majority of NTRK1, NTRK2, and NTRK3 rearrangements result in increased expression of the kinase portion of the involved gene due to its fusion to an actively transcribed gene partner.
Aglaya Iyevleva, Elena Preobrazhenskaya, Vladislav Tiurin   +2 more
exaly   +2 more sources

Relationship of a Variant in theNTRK1Gene to White Matter Microstructure in Young Adults [PDF]

Journal of Neuroscience, 2012
Free to read\ud \ud The NTRK1 gene (also known as TRKA) encodes a high-affinity receptor for NGF, a neurotrophin involved in nervous system development and myelination.
Margaret Wright, Paul Thompson, Katie McMahon   +2 more
exaly   +2 more sources

A Potential Prognostic Gene Signature Associated with p53-Dependent NTRK1 Activation and Increased Survival of Neuroblastoma Patients

Cancers
Neuroblastoma is the most common extracranial solid tumour in children, comprising close to 10% of childhood cancer-related deaths. We have demonstrated that activation of NTRK1 by TP53 repression of PTPN6 expression is significantly associated with ...
Marios Vardakastanis, Nicole Wong, William Macmorland   +2 more
exaly   +2 more sources