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Relationship of a Variant in the NTRK1 Gene to White Matter Microstructure in Young Adults [PDF]
The Journal of Neuroscience, 2012 The NTRK1 gene (also known as TRKA) encodes a high-affinity receptor for NGF, a neurotrophin involved in nervous system development and myelination. NTRK1 has been implicated in neurological function via links between the T allele at rs6336 (NTRK1-T) and
Meredith N. Braskie +11 more
semanticscholar +4 more sources
Genetics and Molecular Research, 2012 Congenital insensitivity to pain with anhidrosis (CIPA; MIM 256800) is a rare autosomal recessive disorder characterized by absence of reaction to noxious stimuli, recurrent episodes of fever, anhidrosis, and mental retardation. It is caused by mutations in the gene coding for neurotrophic tyrosine kinase receptor type 1 (NTRK1; MIM# 191315).
Min Li +4 more
semanticscholar +3 more sources
Transcriptomics reveals the effects of NTRK1 on endoplasmic reticulum stress response-associated genes in human neuronal cell lines [PDF]
PeerJ, 2023 Background NTRK1 gene, encoding TrkA, is essential for the nervous system and drives a variety of biological processes, including pain. Given the unsatisfied analgesic effects of some new drugs targeting NTRK1 in clinic, a deeper understanding for the ...
Bo Jiao +7 more
doaj +2 more sources
NTRK expression and its clinical significance in pancreatic neuroendocrine tumors [PDF]
Discover OncologyBackground The neurotrophic TRK family, which includes NTRK1, 2, and 3, could be the oncogenic driving force in various cancers, when they undergo fusion mutations with other genes and form a chimeric oncoprotein.
Pingping Yan +5 more
doaj +2 more sources
bioRxiv, 2023 Digital PCR (dPCR) is emerging as an ideal platform for the detection and tracking of genomic variants in cancer due to its high sensitivity and simple workflow.
Bryan Leatham +10 more
semanticscholar +1 more source