Results 91 to 100 of about 31,361 (244)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The Prolyl Isomerase Pin1 Promotes the Herpesvirus-Induced Phosphorylation-Dependent Disassembly of the Nuclear Lamina Required for Nucleocytoplasmic Egress. [PDF]

PLoS Pathogens, 2016
The nuclear lamina lines the inner nuclear membrane providing a structural framework for the nucleus. Cellular processes, such as nuclear envelope breakdown during mitosis or nuclear export of large ribonucleoprotein complexes, are functionally linked to
Jens Milbradt, Corina Hutterer, Hanife Bahsi, Sabrina Wagner, Eric Sonntag, Anselm H C Horn, Benedikt B Kaufer, Yasuko Mori, Heinrich Sticht, Torgils Fossen, Manfred Marschall   +10 more
doaj   +1 more source

The M, E, and N structural proteins of the severe acute respiratory syndrome coronavirus are required for efficient assembly, trafficking, and release of virus-like particles [PDF]

, 2008
Copyright @ 2008 American Society for Microbiology.The production of virus-like particles (VLPs) constitutes a relevant and safe model to study molecular determinants of virion egress.
Altmeyer, R, Bruzzone, R, Chan, CM, Escriou, N, Kien, F, Lo, J, Nal, B, Nicholls, JM, Peiris, JSM, Siu, YL, Teoh, KT, Tsao, SW   +11 more
core   +5 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization

Scientific Reports, 2018
ALS (Amyotrophic Lateral Sclerosis) is a neurodegenerative disease characterized by the redistribution of the RNA binding protein TDP-43 in affected neurons: from predominantly nuclear to aggregated in the cytosol.
Emile S. Pinarbasi, Tolga Cağatay, Ho Yee Joyce Fung, Ying C. Li, Yuh Min Chook, Philip J. Thomas   +5 more
doaj   +1 more source

Visualization of DNA G-quadruplexes in herpes simplex virus 1-infected cells [PDF]

, 2016
We have previously shown that clusters of guanine quadruplex (G4) structures can form in the human herpes simplex-1 (HSV-1) genome. Here we used immunofluorescence and immune-electron microscopy with a G4-specific monoclonal antibody to visualize G4 ...
Artusi, Sara, Di Iorio, Mario Vincenzo, Lago, Sara, Palu', Giorgio, Perrone, Rosalba, Raffa, Paolo, Richter, Sara   +6 more
core   +1 more source

Proteomic Analysis of the Multimeric Nuclear Egress Complex of Human Cytomegalovirus

Molecular & Cellular Proteomics, 2014
Herpesviral capsids are assembled in the host cell nucleus before being translocated into the cytoplasm for further maturation. The crossing of the nuclear envelope represents a major event that requires the formation of the nuclear egress complex (NEC).
Milbradt, Jens, Kraut, Alexandra, Hutterer, Corina, Sonntag, Eric, Schmeiser, Cathrin, Ferro, Myriam, Wagner, Sabrina, Lenac, Tihana, Claus, Claudia, Pinkert, Sandra, Hamilton, Stuart, Rawlinson, William, Sticht, Heinrich, Couté, Yohann, Marschall, Manfred   +14 more
openaire   +5 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights into Inner Nuclear Membrane Remodeling

Cell Reports, 2015
Although nucleo-cytoplasmic transport is typically mediated through nuclear pore complexes, herpesvirus capsids exit the nucleus via a unique vesicular pathway. Together, the conserved herpesvirus proteins pUL31 and pUL34 form the heterodimeric nuclear egress complex (NEC), which, in turn, mediates the formation of tight-fitting membrane vesicles ...
Zeev-Ben-Mordehai, Tzviya, Weberruss, Marion, Lorenz, Michael, Cheleski, Juliana, Hellberg, Teresa, Whittle, Cathy, El Omari, Kamel, Vasishtan, Daven, Dent, Kyle C., Harlos, Karl, Franzke, Kati, Hagen, Christoph, Klupp, Barbara G., Antonin, Wolfram, Mettenleiter, Thomas C., Gruenewald, Kay   +15 more
openaire   +4 more sources