Results 41 to 50 of about 193,321 (268)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A new theoretical performance analysis method considering longitudinal and transverse end effects for flat linear induction magnetohydrodynamic pumps

Frontiers in Nuclear Engineering
The flat linear induction pumps (FLIPs) are a class of driving devices that converts electromagnetic energy into mechanical energy of pumped liquid metal, which are widely used in the field of energy power and chemical industries.
Ming Ding, Chunwei Yang, Yifan Bai, Keming Bi, Xin Yan   +4 more
doaj   +1 more source

Education and Training of Future Nuclear Engineers Through The use of An Interactive Plant Simulator. [PDF]

, 2010
The International Atomic Energy Agency (IAEA) sponsors the development of nuclear reactor simulators for education, or arranges the supply of such simulation programs [1].
Ahnert Iglesias, Carolina, Aragonés Beltrán, José María, Blanco, Julio, Cabellos de Francisco, Oscar Luis, Cuervo Gómez, Diana, Gallego Díaz, Eduardo F., García Herranz, Nuria, Lorente Fillol, Alfredo, Mínguez Torres, Emilio, Piedra, David, Rebollo, Luis   +10 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

The CIELO collaboration: Progress in international evaluations of neutron reactions on Oxygen, Iron, Uranium and Plutonium

EPJ Web of Conferences, 2017
The CIELO collaboration has studied neutron cross sections on nuclides that significantly impact criticality in nuclear technologies – 16O, 56Fe, 235,8U and 239Pu – with the aim of improving the accuracy of the data and resolving previous discrepancies ...
Chadwick M.B., Capote R., Trkov A., Kahler A.C., Herman M.W., Brown D.A., Hale G.M., Pigni M., Dunn M., Leal L., Plompen A., Schillebeeck P., Hambsch F.-J., Kawano T., Talou P., Jandel M., Mosby S., Lestone J., Neudecker D., Rising M., Paris M., Nobre G.P.A., Arcilla R., Kopecky S., Giorginis G., Cabellos O., Hill I., Dupont E., Danon Y., Jing Q., Zhigang G., Tingjin L., Hanlin L., Xichao R., Haicheng W., Sin M., Bauge E., Romain P., Morillon B., Noguere G., Jacqmin R., Bouland O., De Saint Jean C., Pronyaev V.G., Ignatyuk A., Yokoyama K., Ishikawa M., Fukahori T., Iwamoto N., Iwamoto O., Kuneada S., Lubitz C.R., Palmiotti G., Salvatores M., Kodeli I., Kiedrowski B., Roubtsov D., Thompson I., Quaglioni S., Kim H.I., Lee Y.O., Koning A.J., Carlson A., Fischer U., Sirakov I.   +64 more
doaj   +1 more source

Creating a Canadian profession: the nuclear engineer, c. 1940-1968 [PDF]

, 2009
Canada, as one of the three Allied nations collaborating on atomic energy development during the Second World War, had an early start in applying its new knowledge and defining a new profession. Owing to postwar secrecy and distinct national aims for the
Johnston, S.F.
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

HRXRD study of the theoretical densities of novel reactive sintered boride candidate neutron shielding materials [PDF]

, 2020
Reactive Sintered Borides (RSBs) are novel borocarbide materials derived from FeCr-based cemented tungsten (FeCr-cWCs) show considerable promise as compact radiation armour for proposed spherical tokamak,[1],[2],[3],[4],[5].
Marshall, Jessica M., Thomas, Pam A., Walker, David   +2 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source