Results 61 to 70 of about 195,424 (265)
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
Numerical Analysis of Turbulent Mixed Convection in Vertical Annular Channel
Yuanzineng kexue jishu, 2023 Reactor cavity cooling system (RCCS) is a competitive residual heat removal scheme for small modular reactors. In this paper, the RCCS has been simplified to a scenario that ascending air flow is got heated in vertical annular channels and driven by ...
HU Xiangjie;WEN Jiming;GAO Puzhen;TIAN Ruifeng
doaj
Simulation of ion track ranges in uranium oxide
, 2010 Direct comparisons between statistically sound simulations of ion-tracks and published experimental measurements of range densities of iodine implants in uranium dioxide have been made with implant energies in the range of 100-800 keV.
Beardmore +17 more
core +1 more source
Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells
FEBS Open Bio, EarlyView.UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca +6 more
wiley +1 more source
Eugene P. Wigner’s Visionary Contributions to Generations-I through IV Fission Reactors
EPJ Web of Conferences, 2014 Among Europe’s greatest scientists who fled to Britain and America in the 1930s, Eugene P. Wigner made instrumental advances in reactor physics, reactor design and technology, and spent nuclear fuel processing for both purposes of developing atomic ...
Carré Frank
doaj +1 more source
A suggested roadmap for world-wide energy resource planning and management [PDF]
, 2015 In the near future, we will need an internationally based system for worldwide planning of future energy resources and their effect on the world environment.
Boothroyd, R. G.
core +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Diagnostic systems in DEMO: engineering design issues
, 2014 The diagnostic systems of DEMO that are mounted on or near the torus, whether intended for the monitoring and control functions of the engineering aspects or the physics behaviour of the machine, will have to be designed to suit the hostile nuclear ...
Todd, T N
core +1 more source
Magnetometry with nitrogen-vacancy defects in diamond [PDF]
, 2014 The isolated electronic spin system of the Nitrogen-Vacancy (NV) centre in diamond offers unique possibilities to be employed as a nanoscale sensor for detection and imaging of weak magnetic fields.
Hingant, T. +5 more
core +3 more sources