Results 51 to 60 of about 193,321 (268)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Diagnostic systems in DEMO: engineering design issues
, 2014 The diagnostic systems of DEMO that are mounted on or near the torus, whether intended for the monitoring and control functions of the engineering aspects or the physics behaviour of the machine, will have to be designed to suit the hostile nuclear ...
Todd, T N
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Research on Lightweight Technology of Hydraulic Components for Integrated Fast Reactor Main Pump
Yuanzineng kexue jishuTo meet the requirements of our country’s nuclear energy development and defense technology industry development, and to achieve national carbon neutrality and energy security needs, it is necessary to comprehensively break through and master the key ...
PU Enshan1, ZHAI Xiao1, GU Jipin1, LIU Simin1, ZHANG Xu2
doaj +1 more source
Optimization Research of Neutron Flux Density Monitoring Method during Refueling for Tianwan NPP
Yuanzineng kexue jishu, 2023 The ex-core nuclear instrument equipment consists of the source range detector, the start-up and work range detector and the refueling monitoring range detector in Tianwan nuclear power plant (NPP). The neutron flux density of the reactor is monitored by
LYU Niu;LI Dongpeng;XIA Zhaodong;WANG Yang
doaj
A Worst Practices Guide to Insider Threats: Lessons from Past Mistakes [PDF]
, 2014 Insider threats are perhaps the most serious challenges that nuclear security systems face. All of the cases of theft of nuclear materials where the circumstances of the theft are known were perpetrated either by insiders or with the help of insiders ...
Matthew Bunn, Scott D. Sagan
core
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Resonance region measurements of dysprosium and rhenium
EPJ Web of Conferences, 2017 Neutron capture and transmission measurements have been performed, and resonance parameter analysis has been completed for dysprosium, Dy, and rhenium, Re. The 60 MeV electron accelerator at RPI Gaerttner LINAC Center produced neutrons in the thermal and
Leinweber Gregory +14 more
doaj +1 more source
Explorative Nanophilosophy as Tecnoscienza: An Italian Perspective on the Role of Speculation in Nanoindustry [PDF]
, 2019 There are two primary camps in which nanotechnology today can be categorized normal nanotechnology and speculative nanotechnology. The birth of nanotechnology proper was conceived through discourses of speculative nanotechnology.
Umbrello, Steven
core +3 more sources
Consistency Index-Based Sensor Fault Detection System for Nuclear Power Plant Emergency Situations Using an LSTM Network [PDF]
, 2020 A nuclear power plant (NPP) consists of an enormous number of components with complex interconnections. Various techniques to detect sensor errors have been developed to monitor the state of the sensors during normal NPP operation, but not for emergency ...
Choi, Jeonghun, Lee, Seung Jun
core +1 more source