Results 61 to 70 of about 193,321 (268)

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Performance Test of High-temperature Immersion Pump for In-reactor Purification of Integrated Fast Reactor

Yuanzineng kexue jishu
In the integrated fast reactor project of the China Institute of Atomic Energy, in order to keep the primary circuit sodium within the reactor and prevent radioactive sodium leakage, an in-reactor cold trap is used to purify the impurities in the sodium,
LI Xu1, GENG Xiao1, YAO Zewen1, , YU Chunli1, WU Peng2, YU Genfang2
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Numerical Analysis of Turbulent Mixed Convection in Vertical Annular Channel

Yuanzineng kexue jishu, 2023
Reactor cavity cooling system (RCCS) is a competitive residual heat removal scheme for small modular reactors. In this paper, the RCCS has been simplified to a scenario that ascending air flow is got heated in vertical annular channels and driven by ...
HU Xiangjie;WEN Jiming;GAO Puzhen;TIAN Ruifeng
doaj  

Internationalization of the Nuclear Fuel Cycle: Goals, Strategies, and Challenges [PDF]

, 2008
Presents U.S. and Russian experts' analyses of and recommendations on options for securing the international nuclear fuel cycle, including the provision of fuel to countries pursuing nuclear power to dissuade them from building uranium enrichment ...

core  

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Eugene P. Wigner’s Visionary Contributions to Generations-I through IV Fission Reactors

EPJ Web of Conferences, 2014
Among Europe’s greatest scientists who fled to Britain and America in the 1930s, Eugene P. Wigner made instrumental advances in reactor physics, reactor design and technology, and spent nuclear fuel processing for both purposes of developing atomic ...
Carré Frank
doaj   +1 more source

From micro to nano scales -recent progress in the characterization of nitrided austenitic stainless steels [PDF]

, 2015
In the frontier of materials science, understanding of materials has been in multiple scales from macro, micro, to atomic levels. This is attributed to the advanced instrumentations such as SEM, TEM, XPS, XRD, as well as several other spectroscopic and ...
Luo, Quanshun, Yang, Shicai
core   +1 more source