Results 41 to 50 of about 138,674 (288)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Human Telomeres Are Tethered to the Nuclear Envelope during Postmitotic Nuclear Assembly
Cell Reports, 2012 Telomeres are essential for nuclear organization in yeast and during meiosis in mice. Exploring telomere dynamics in living human cells by advanced time-lapse confocal microscopy allowed us to evaluate the spatial distribution of telomeres within the ...
Laure Crabbe +4 more
doaj +1 more source
Microtubule Organization in Striated Muscle Cells
Cells, 2020 Distinctly organized microtubule networks contribute to the function of differentiated cell types such as neurons, epithelial cells, skeletal myotubes, and cardiomyocytes.
Robert Becker +2 more
doaj +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
eLife, 2019 The integrity of the nuclear membranes coupled to the selective barrier of nuclear pore complexes (NPCs) are essential for the segregation of nucleoplasm and cytoplasm.
David J Thaller +5 more
doaj +1 more source
SnapShot: The Nuclear Envelope II
Cell, 2012 Nup160 Nup160 CG4738 NPP-6 Nup120 SPBC3B9.16c Nup120Nup133 Nup133 CG6958 NPP-15 Nup132, Nup131 SPAC1805.04, SPBP35G2.06cNup133Nup107 Nup107 CG6743 NPP-5 Nup107 SPBC428.01c Nup84Nup96 Nup96 CG10198 NPP-10C Nup189C SPAC1486.05 Nup145CNup85 (PCNT1) Nup75 CG5733 NPP-2 Nup-85 SPBC17G9.04c Nup85Seh1 Nup44A CG8722 NPP-18 Seh1 SPAC15F9.02 Seh1Sec13 Sec13 ...
Rothballer Andrea, Kutay Ulrike
openaire +3 more sources
Nuclear envelope remodelling during mitosis
Current Opinion in Cell Biology, 2021 The defining feature of the eukaryotic cell, the nucleus, is bounded by a double envelope. This envelope and the nuclear pores within it play a critical role in separating the genome from the cytoplasm. It also presents cells with a challenge. How are cells to remodel the nuclear compartment boundary during mitosis without compromising nuclear function?
Gautam Dey, Buzz Baum
openaire +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
TorsinA in the nuclear envelope [PDF]
Proceedings of the National Academy of Sciences, 2004 Early-onset torsion dystonia, a CNS-based movement disorder, is usually associated with a single amino acid deletion (ΔE302/303) in the protein torsinA. TorsinA is an AAA+ ATPase in the endoplasmic reticulum, but what it does is unknown. Here, we use torsinA mutants with defects in ATP hydrolysis (E171Q, ATP-bound) and ATP binding (K108A, ATP-free) to ...
Teresa V, Naismith +3 more
openaire +2 more sources