Results 211 to 220 of about 102,700 (257)
Nuclear export of proteins and RNAs
Current Opinion in Cell Biology, 1997 Our understanding of protein export from the nucleus to the cytoplasm has been advanced recently by the discovery of active, signal-mediated export pathways. Nuclear export signals have been identified in several proteins, the majority of which are RNA-binding proteins.
Gideon Dreyfuss +2 more
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Current Opinion in Genetics & Development, 1994
The export of mRNA from the nucleus to the cytoplasm is an essential step in the expression of genetic information in eukaryotes. It is an energy-dependent process and involves transport across the nuclear pores. It requires both cis-acting ribonucleoprotein particle signals and specific trans-acting factors. Although much remains to be learned, recent
D J, Elliott +3 more
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The export of mRNA from the nucleus to the cytoplasm is an essential step in the expression of genetic information in eukaryotes. It is an energy-dependent process and involves transport across the nuclear pores. It requires both cis-acting ribonucleoprotein particle signals and specific trans-acting factors. Although much remains to be learned, recent
D J, Elliott +3 more
openaire +2 more sources
Nuclear export of proteins: The role of nuclear retention
Cell, 1993Proteins that shuttle between nucleus and cytoplasm are implicated in transport and signal transduction processes. Using assays based on interspecies heterokaryons and microinjection of Xenopus oocytes, we examined what structural features determine nuclear export of shuttling proteins.
Schmidt-Zachmann, M. S. +3 more
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Nuclear export of ribosomal subunits
Trends in Biochemical Sciences, 2002The partitioning of cells by a nuclear envelope ensures that precursors of ribosomes do not interact prematurely with other components of the translation machinery. Ribosomal subunits are assembled in nucleoli and exported to the cytoplasm in a CRM1/Ran-GTP-dependent fashion. Export of the large (60S) subunit requires a shuttling adaptor protein, NMD3,
Arlen Johnson, Elsebet Lund
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Nuclear export signal in CDC25B
Biochemical and Biophysical Research Communications, 2004CDC25B is a dual-specificity phosphatase that activates CDK1/cyclin B. The nuclear exclusion of CDC25B is controlled by the binding of 14-3-3 to the nuclear export signal (NES) of CDC25B, which was reported to be amino acids H28 to L40 in the N-terminal region of CDC25B.
Sanae, Uchida +8 more
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Nuclear Export of MicroRNA Precursors
Science, 2004MicroRNAs (miRNAs), which function as regulators of gene expression in eukaryotes, are processed from larger transcripts by sequential action of nuclear and cytoplasmic ribonuclease III–like endonucleases. We show that Exportin-5 (Exp5) mediates efficient nuclear export of short miRNA precursors (pre-miRNAs) and that its depletion by RNA interference ...
Elsebet, Lund +4 more
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2002
In the past few years, the study of transport of macromolecules between the nucleus and the cytoplasm has produced an overwhelming amount of data which have been formulated into convincing mechanistic models of nucleocytoplasmic transport. We will briefly introduce these current models in the field of nucleocytoplasmic transport (recently reviewed in ...
George, Simos +2 more
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In the past few years, the study of transport of macromolecules between the nucleus and the cytoplasm has produced an overwhelming amount of data which have been formulated into convincing mechanistic models of nucleocytoplasmic transport. We will briefly introduce these current models in the field of nucleocytoplasmic transport (recently reviewed in ...
George, Simos +2 more
openaire +2 more sources
Trends in Biochemical Sciences, 2010
The nuclear export of mRNA, in which Mex67-Mtr2 mediates movement of mature transcripts through nuclear pores, represents the culmination of the nuclear portion of the gene expression pathway. Nuclear export is closely integrated with transcription and processing, and is based on forming a messenger ribonucleoprotein (mRNP) export complex in the ...
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The nuclear export of mRNA, in which Mex67-Mtr2 mediates movement of mature transcripts through nuclear pores, represents the culmination of the nuclear portion of the gene expression pathway. Nuclear export is closely integrated with transcription and processing, and is based on forming a messenger ribonucleoprotein (mRNP) export complex in the ...
openaire +2 more sources
Current Opinion in Cell Biology, 1991
Nuclear mRNA export through the nuclear pore complex has been proposed to be a unidirectional, signal-mediated and energy-dependent process. Evidence exists that this process can be influenced by many factors including other steps in the pathway of cytoplasmic mRNA formation, sequences of the RNA substrate that are either transcribed or added co- or ...
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Nuclear mRNA export through the nuclear pore complex has been proposed to be a unidirectional, signal-mediated and energy-dependent process. Evidence exists that this process can be influenced by many factors including other steps in the pathway of cytoplasmic mRNA formation, sequences of the RNA substrate that are either transcribed or added co- or ...
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Nuclear export complexes in the frame
Current Opinion in Structural Biology, 2010Protein and RNA molecules are exchanged between the nucleus and cytoplasm by members of the karyopherin beta family of transport factors. Karyopherins adopt a modular HEAT-repeat architecture and are regulated by the GTPase Ran. RanGTP acts as a signal for the nuclear compartment, dissociating molecular cargo from karyopherins that mediate nuclear ...
Cook, A., Conti, E.
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