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Nuclear import-export: In search of signals and mechanisms
Cell, 1991E. A. Nigg,’ P. A. Baeuerle,t and R. LiihrmannS *Swiss Institute for Experimental Cancer Research CH-1066 Epalinges Switzerland TGenzentrum der Ludwig-Maximilians-Universitkt D-8033 Martinsried Germany *lnstitut fiir Molekularbiologie und Tumorforschung Universitat Marburg D-3550 Marburg Germany In eukaryotic cells, there is continuous exchange of ...
Nigg, E. A. +2 more
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Signal transduction meets nuclear export
Trends in Cell Biology, 1998Abstract ENGEL, K. et al . (1998) Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation EMBO J.
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Leucine-rich nuclear-export signals: born to be weak
Trends in Cell Biology, 2005CRM1 mediates the nuclear export of proteins exposing leucine-rich nuclear-export signals (NESs). Most NESs bind to CRM1 with relatively low affinity. Recently, higher-affinity NESs were selected from a 15-mer random peptide library. Unexpectedly, complexes between high-affinity NESs and CRM1 accumulate at the cytoplasmic filaments of the nuclear pore ...
Kutay U, Güttinger S
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Targeting The Nuclear Export Signal In Multiple Myeloma
Blood, 2013Abstract Introduction In multiple myeloma (MM), de novo drug resistance to topoisomerase (topo) II poisons occurs at high cell densities due to trafficking of topo IIα from the nucleus to the cytoplasm where it is no longer in contact with the DNA and thus unable to induce cell death (Turner et al ...
Joel G Turner +6 more
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