Results 251 to 260 of about 3,507,867 (287)
Extracellular signal-regulated kinase 3 forms a nuclear complex with Aly/REF export factor and the splicing factor proline and glutamine rich to exacerbate pathological cardiac remodeling due to pressure overload. [PDF]
Mol BiomedZhou WY +11 more
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FAK nuclear export signal sequences [PDF]
FEBS Letters, 2008 Ubiquitously expressed focal adhesion kinase (FAK), a critical component in transducing signals from sites of cell contacts with extracellular matrix, was named after its typical localization in focal adhesions.
Steve Lim, Dusko Ilic, David Schlaepfer
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Transport of galectin-3 between the nucleus and cytoplasm. II. Identification of the signal for nuclear export. [PDF]
Glycobiology, 2006 Galectin-3, a factor involved in the splicing of pre-mRNA, shuttles between the nucleus and the cytoplasm. Previous studies have shown that incubation of fibroblasts with leptomycin B resulted in the accumulation of galectin-3 in the nucleus, suggesting ...
Ronald J Patterson
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Nuclear export signal in CDC25B
Biochemical and Biophysical Research Communications, 2004CDC25B is a dual-specificity phosphatase that activates CDK1/cyclin B. The nuclear exclusion of CDC25B is controlled by the binding of 14-3-3 to the nuclear export signal (NES) of CDC25B, which was reported to be amino acids H28 to L40 in the N-terminal region of CDC25B.
Sanae, Uchida +8 more
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An RNA-export mediator with an essential nuclear export signal
Nature, 1996The Rev protein of human immunodeficiency virus type 1 (HIV-1) mediates the translocation of viral messenger RNAs from the nucleus to the cytoplasm. In yeast, Rev can mediate the nuclear export of Rev response-element-containing RNAs. The export of Rev itself proceeds through the nuclear pore complex and requires a nuclear export signal (NES) and ...
R, Murphy, S R, Wente
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2022
The Karyopherin protein CRM1 or XPO1 is the major nuclear export receptor that regulates nuclear exit of thousands of macromolecules in the cell. CRM1 recognizes protein cargoes by binding to their 8-15 residue-long nuclear export signals (NESs). A ternary CRM1-Ran-RanBP1 complex engineered to be suitable for crystallization has enabled structure ...
Ho Yee Joyce, Fung, Yuh Min, Chook
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The Karyopherin protein CRM1 or XPO1 is the major nuclear export receptor that regulates nuclear exit of thousands of macromolecules in the cell. CRM1 recognizes protein cargoes by binding to their 8-15 residue-long nuclear export signals (NESs). A ternary CRM1-Ran-RanBP1 complex engineered to be suitable for crystallization has enabled structure ...
Ho Yee Joyce, Fung, Yuh Min, Chook
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Binding Affinity Measurement of Nuclear Export Signal Peptides to Their Exporter CRM1
2022CRM1 recognizes hundreds to thousands of protein cargoes by binding to the eight to fifteen residue-long nuclear export signals (NESs) within their polypeptide chains. Various assays to measure the binding affinity of NESs for CRM1 have been developed.
Ho Yee Joyce, Fung, Yuh Min, Chook
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Virology, 2006 Morbilliviruses, which belong to the Mononegavirales, replicate its RNA genome in the cytoplasm of the host cell. However, they also form characteristic intranuclear inclusion bodies, consisting of nucleoprotein (N), in infected cells. To analyze the mechanisms of nucleocytoplasmic transport of N protein, we characterized the nuclear localization (NLS)
Chieko Kai, Misako Yoneda, Ryuichi Miura
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Nuclear Import and Export Signals
2007Eukaryotic cells are separated into two large compartments, namely the nucleus and the cytoplasm, by the nuclear envelope. As a result, macromolecules including RNAs, which are transcribed in the nucleus and nuclear proteins, which are translated in the cytoplasm must cross the double Upid bilayer to reach the intracellular sites where they function ...
Toshihiro Sekimoto +2 more
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