Results 241 to 250 of about 3,507,867 (287)

Enterovirus D68 2A protease causes nuclear pore complex dysfunction and independently contributes to motor neuron toxicity. [PDF]

Elife
Zinn KM, McLaren MW, Imai MT, Jayaram MM, Rothstein JD, Elrick MJ.   +5 more
europepmc   +1 more source

Ciliary Membrane Lipid Homeostasis in Health and Disease

Advanced Science, EarlyView.
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang, Yuan‐yuan Liu, Hanqi Sun, Peiwei Liu   +3 more
wiley   +1 more source

Unexpected functional role of the transactivation domain for nuclear import of STAT5. [PDF]

Commun Biol
Ernst S, Borgen-Möller M, Küster A, Schurse H, Müller-Newen G.   +4 more
europepmc   +1 more source

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

Nucleoporins in Cancer: Functional Roles and Therapeutic Opportunities. [PDF]

Cancer Discov
Kirthika P, Jawalagatti V, Carceles-Cordon M, Domingo-Domenech J, Rodriguez-Bravo V.   +4 more
europepmc   +1 more source

Magnetoreceptor Promotes Hepatocellular Carcinoma Development and Blunts Sorafenib‐Induced Ferroptosis by Regulating Iron Homeostasis

Advanced Science, EarlyView.
Magnetoreceptor (MagR) regulates iron homeostasis and mitochondrial function in hepatocellular carcinoma (HCC) cells. Specifically, MagR deficiency suppresses tumor cell proliferation, migration, and invasion and enhances sorafenib‐induced ferroptosis through iron accumulation.
Tao Wang, Chenghua Song, Xin He, Mengzhou Wang, Wuming Liu, Xiaolin Wang, Yuanyuan Zhang, Jia Zhang, Lin Zhang, Dan Li, Yu Zhang, Zheng Wu, Yi Lyu, Rongqian Wu   +13 more
wiley   +1 more source

FgNup2 regulates nuclear import of the histone H2B monoubiquitination enzyme by stabilizing the FgImpα-FgBre1 complex to mediate pathogenicity in Fusarium graminearum. [PDF]

PLoS Pathog
Wang Y, Li Z, Wang X, Xiong B, Zhang C, Zhao X, Wang S, Chen L.   +7 more
europepmc   +1 more source

Comprehensive genomic analysis of five kindreds with multiple childhood leukemias: importance of individual functional analysis for rare ETV6 germline variants. [PDF]

Hum Cell
Yamada A, Nagasawa S, Nakagawa M, Kamimura S, Inoue N, Watanabe H, Takagi M, Koga Y, Keino D, Nakayama H, Yoshimura J, Doi K, Mitsui J, Tsuji S, Moritake H.   +14 more
europepmc   +1 more source

Dual Antiviral and Immunomodulatory Effects of Phytochemicals in Influenza A Virus Infection: Targeting Key Host Signaling Pathways. [PDF]

Microbiologyopen
Chowdhury D, Vanderven HA, Wangchuk P, Sarker S.   +3 more
europepmc   +1 more source

The long and winding road: On the endoplasmic reticulum of Plasmodium and implications for pathogenesis. [PDF]

PLoS Pathog
Blank A, Ngwira S, Fierro MA.
europepmc   +1 more source