Results 241 to 250 of about 17,238,583 (283)

Nuclear factor-kappa B, cancer, and apoptosis.

open access: yesBiochemical pharmacology, 2000
The role of nuclear factor (NF)-kappa B in the regulation of apoptosis in normal and cancer cells has been extensively studied in recent years. Constitutive NF-kappa B activity in B lymphocytes as well as in Hodgkin's disease and breast cancer cells protects these cells against apoptosis.
V, Bours   +7 more
openaire   +3 more sources

Crocodylian nuclear factor kappa B

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2017
We deduced the amino acid (aa) sequence of the nuclear factor kappa B (NFκB) protein from genomic data for the American alligator (Alligator mississippiensis), the estuarine crocodile (Crocodylus porosus), and the Indian gharial (Gavialis gangeticus).
Mark, Merchant   +4 more
openaire   +2 more sources

Nuclear factor-kappa B and effector molecules in photoaging

Cutaneous and Ocular Toxicology, 2022
Nuclear factor-kappa B (NF-κB) has important but complex functions in the photoaging of the human skin. This protein complex is activated upon UV irradiation and plays a key role in the signalling pathway of the inflammatory cascade. NF-κB induces the expression of various proinflammatory cytokines, such as tumour necrosis factor (TNF) and interleukin ...
Qiang, Zhang   +3 more
openaire   +2 more sources

Nuclear factor kappa B and hepatitis viruses

Expert Opinion on Therapeutic Targets, 2008
Hepatitis can be caused by a number of viruses, which have similar clinical manifestations and render infected individuals at high risk of death from cirrhosis and liver cancer. Current therapies for hepatitis have limited effects and unsatisfactory patient outcomes.
Yong-Song, Guan   +3 more
openaire   +2 more sources

Nuclear Factor-Kappa B: From Clone to Clinic

Current Molecular Medicine, 2007
Nuclear transcription factor kappaB (NF-kappaB) was first discovered in 1986 in the nucleus of the B cell as an enhancer in the kappa immunoglobulin chain. However, this factor has identified in the cytoplasm in the resting state. When activated in response to inflammatory stimuli, carcinogens, stress, ionizing radiation, and growth factors; NF-kappaB ...
Kwang Seok, Ahn   +2 more
openaire   +2 more sources

Activation of nuclear factor kappa B in Crohn's disease

Inflammation Research, 1998
The location and degree of activation of nuclear factor kappa (NFkappaB), a primary transcription factor that plays a regulating role in immune and inflammatory responses, was determined in Crohn's disease using full thickness specimens of bowel collected at surgery.Resected specimens of inflamed and non-inflamed bowel were collected from thirteen ...
R D, Ellis   +5 more
openaire   +2 more sources

Nuclear Factor-kappa B

2007
The Nuclear Factor-kappa B (NF-κB) represents a family of transcription factors that controls a variety of processes related to immunity and development. This family of transcription factors is conserved from insects to humans. Five different proteins, encoded by five different genes, of this family are present in mammals and three related proteins are
Keith W. Clem, Y. Tony Ip
openaire   +1 more source

The Transcription Factor Nuclear Factor-kappa B and Cancer

Clinical Oncology, 2007
Since the discovery of nuclear factor-kappa B (NF-kappaB) in 1986, many studies have been conducted showing the link between the NF-kappaB signalling pathway and control of the inflammatory response. Today it is well known that control of the inflammatory response and apoptosis is closely related to the activation of NF-kappaB.
R O, Escárcega   +4 more
openaire   +2 more sources

Nuclear Factor Kappa-B Activation by Particles and Fibers

Inhalation Toxicology, 2000
In recent years, particle research has focused on activation pathways of transcription factors that are known to regulate genes whose abnormal expression is associated with the pathogenesis of particle-associated lung disorders such as fibrosis, cancer, COPD, and asthma.
R P, Schins, K, Donaldson
openaire   +2 more sources

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